Hexavite

Hexavit is a multivitamin drug complex that does not contain additives.

Indications of the hexavita

It is used in such cases:

• when eliminating hypovitaminosis in adults, as well as children, and at the same time as a preventive measure against the development of this pathology;
• for people whose occupations require increased visual acuity (for public transport drivers, pilots, and operators operating on cranes);
• to strengthen the body's immunity against colds and infections during various epidemics;
• in a period of prolonged treatment with the use of antibiotics.

Release form

Release in the form of a dragee, 50 pieces in jars, 1 jar in a separate pack. Also can be produced in bags containing 1 kg of medicinal tablets.

Pharmacodynamics

A multivitamin preparation, the effect of which is due to the presence of various vitamins. They participate in metabolic processes that regulate homeostasis (both in the healthy state of the organism and in the disease). Due to the fact that vitamins are present in the complex, a more diverse and pronounced biological effect from their effects is observed.

The substance retinol helps the development of epithelial cells, and also promotes the processes of binding the visual pigment.

Thiamine restores the functions of the digestive system, in addition to CCC and HC.

The riboflavin component is an important participant in the metabolism of fats and proteins with carbohydrates, and in addition restores skin functions and maintains visual acuity at the required level.

Vitamin nicotinamide is a specific anti-pelagic substance that helps improve the metabolism of carbohydrates.

The substance pyridoxine is required for the healing of the skin and liver cells, and in addition to restore the function of HC. Together with this vitamin helps to improve fat metabolism, which develops with atherosclerosis.

Ascorbic acid is very important in regulating oxidation-reduction processes, and in addition, with blood coagulation, carbohydrate metabolism, tissue healing, the formation of steroid type hormones and connective tissue elements, as well as the normalization of capillary permeability. Also, the substance strengthens the body's immune response to infection.

Pharmacokinetics

Vitamins of water-soluble type (from category B, as well as ascorbic acid) are well absorbed in the amount that corresponds to the daily norm required for the body. Remains of the substance are excreted in the urine, and sometimes also with feces. These vitamins are stored inside the body in a very limited amount, so you need to regularly get them along with food to maintain the required level inside the tissues.

In the case of fat, ingested retinol (a fat-soluble vitamin) is well absorbed through the small intestine.

Dosing and administration

Dragee is taken orally after eating.

In the prevention of the development of hypovitaminosis in adults, one dragee is required per day, and in the case of treatment, 1 tablet is given three times per day.

For prophylaxis in pregnant women (in the third and third trimesters) and in nursing women - taking the 1st dragee once a day (no more). The duration of therapy is prescribed by the doctor individually.

For treatment in children older than 14 years, the medication is required to be taken once per day in the amount of the 1st pellet.

Hexavit is taken in the period of 30 days (this course should be repeated 2-3 times a year), although the duration of the treatment and the frequency of the recurrence of therapy depend on the patient's individual indications, but also on his age, and also the type of disease and degree of its severity.

[1]

Use of the hexavita during pregnancy

Use Hexavit in lactation or pregnancy is permitted only with a higher probability of benefit to a woman than the possibility of a child / fetus having negative reactions.

For pregnant women or those planning a pregnancy, the dosage of retinol may be a maximum of 5000 IU.

In the third and third trimesters, and also during lactation, the medicine is allowed to be taken solely for the purpose of prevention (and only with the appointment of a doctor and under his supervision) in a dosage of a maximum of 1 dragee per day. Use  Hexavit  in therapeutic dosages for lactating women and pregnant women - is prohibited.

Contraindications

The main contraindications:

• heightened sensitivity with respect to the elements of drugs;
• disorders in the work of the kidneys or liver, which have a pronounced character;
• nephrolithiasis with hyperuricemia and gout;
• active form of hepatitis;
• thromboembolism and thrombophlebitis with thrombosis;
• malabsorption syndrome, as well as fructoemia;
• elevated blood pressure in a severe degree;
• hypervitaminosis of type A;
• aggravated ulcers in the area of the duodenum or stomach;
• presence of an anamnesis of sarcoidosis;
• chronic form of glomerulonephritis;
• the disorder of the processes of exchange of copper or iron;
• children's age is less than 14 years.

Side effects of the hexavita

Often, hexavit is tolerated without complications, but these side effects can occur sporadically:

• Immunity disorders: people with intolerance to the drug may develop allergic manifestations, including anaphylaxis and Quincke edema;
• disorders in the work of CAS: increased blood pressure;
• the reaction of the skin and subcutaneous tissues: itching and eruptions with hives, and also dryness of the eye mucous membranes or skin, as well as redness of the skin. Occasionally there are spasms of the bronchi - in people with intolerance to vitamins from category B, C, and also A;
• manifestations of the gastrointestinal tract: vomiting, dyspepsia, stomach pain, eructation, nausea, diarrhea, increased secretion of gastric juice and constipation;
• reactions in the NA: the appearance of dizziness, hot flashes (on their background may have a feeling of heartbeat), headaches, hyperhidrosis and sleep problems. In addition, there may be a feeling of drowsiness, fatigue, increased excitability and irritability;
• disorders of metabolic processes: the development of glucosuria or crystalluria;
• problems from the circulatory system and lymph: disorders of blood turnover, as well as erythrocyte hemolysis in people with deficiency of the G6FD element;
• other: there may be a visual impairment, a urine acquisition of a yellow hue, and the development of hyperthermia;

Long-term intake of vitamins in high doses: may develop a tolerance of glucose, a violation of the metabolism of copper or zinc, and in addition anorexia with hyperglycemia. There may be seizures, abnormalities in the gastrointestinal tract (also irritation of the mucous membranes), erythrocytopenia, arrhythmia and leukocytosis of the neutrophil type. There is a decrease in blood pressure, a temporary increase in the activity of AP and LDH with AST, a balance of electrolytes and renal function disorder, the appearance of cracks and dryness in the area of the foot with palms, hyperpigmentation and seborrheic type rash. Renal insufficiency, myalgia, alopecia, jaundice, myopathy, as well as fatty liver dystrophy develop.

Overdose

As a result of an overdose, dyspeptic symptoms (epigastric pains, along with vomiting with diarrhea and nausea), signs of allergies (skin rash and itching), and also changes in the area of the hair and skin, liver function disorders, facial hyperemia , headaches and a feeling of lethargy, irritability or drowsiness. With such manifestations, you must cancel the use of drugs.

Treatment is aimed at eliminating the symptoms of the disorder. As a result of prolonged intake of ascorbic acid in high doses, the activity of the insular apparatus in the pancreatic region may be suppressed, and in addition there is a change in the processes of urinary excretion as well as ascorbic acid during urine acetylation. As a consequence, there is a risk that oxalate type concretes may precipitate.

Interactions with other drugs

Retinol weakens the anti-inflammatory properties of glucocorticoids. It is forbidden to use it in combination with cholestyramine, as well as nitrites, as they violate the absorption of the substance. In addition, retinol is prohibited to be taken with retinoids, because such a combination is toxic.

Because of the risk of hypervitaminosis type A it is forbidden to combine with other drugs, which contain retinol.

Ascorbic acid potentiates the toxic properties and effectiveness of sulfanilamides (can develop crystalluria), as well as penicillin. In addition, it enhances the absorption of iron and aluminum (therefore it must be carefully combined with aluminum-containing antacids) and weakens the effectiveness of the anticoagulants with indirect action and heparin. The medicine in high doses weakens the medicinal properties of tricyclics with neuroleptics (phenothiazine derivatives), and in addition the processes of reabsorption of amphetamine substance inside the tubules. In addition, hexavit disrupts renal excretion of mexiletine.

Ascorbic acid is allowed to be consumed no earlier than 2 hours after the injection of deferoxamine.

Long-term use of the vitamin complex in high doses weakens the effectiveness of therapy with disulfiram.

Vitamin C increases the overall value of ethanol clearance. It also increases the secretion of oxalates along with urine and increases the likelihood of developing crystalluria in the case of salicylates.

Absorption of ascorbic acid decreases in the case of a combination with oral contraception, as well as with vegetable or fruit juices and alkaline drink.

Thiamin can affect the polarization inside the synapses of the muscles and nerve endings, so that it can reduce the curare like effect from the muscle relaxants.

Riboflavin has an incompatibility with streptomycin, and also reduces the impact of antibacterial drugs (such as doxycycline with oxytetracycline and lincomycin, as well as tetracycline and erythromycin). Amitriptyline with tricyclics and imipramine slows the metabolism of riboflavin (especially inside the heart tissue).

Pyridoxine reduces the effectiveness of levodopa, and in addition prevents or reduces the toxicity of isoniazid and other antituberculous drugs.

In the case of a combination of niacin with lovastatin, rhabdomyolysis can sometimes develop.

[2], [3]

Storage conditions

Hexavite is required to be kept out of reach of children. Temperature values - no more than 25 ° С.

[4]

Shelf life

Hexavit can be used in the period of 1 year from the date of manufacture of the drug.