Hartil

Hartil is a medicinal product used for the treatment of diseases of the cardiovascular system, prevention and treatment of myocardial infarctions. Let's consider the features of this drug, the indications for its use, the dosage and method of administration, the main contraindications and side effects, as well as all the information that the patient needs to know about Hartil.

Hartil has in its composition the active substance ramipril, which refers to inhibitors of the angiotensin-converting enzyme. The drug is prescribed for the treatment of diseases that are characterized by high blood pressure. Hartil helps with complications of acute myocardial infarction, with heart failure and glomerular lesions in diabetes mellitus. Also, Hartil is used for diseases of the ureter and kidneys.

Hartil has a number of analog preparations, which have the same indications for use, but differ in their composition. As a rule, in the absence of Hartil in the pharmacy, you can safely buy: Amprialan, Tritace, Rampiril, Piramil, Korpil and other medications, which the pharmacist or the treating doctor can tell.

[1], [2]

Indications Hartil

Indications for use of Hartil are related to the work of the active substance of this drug and its effect on the body. Hartil is prescribed to patients with such diseases as:

• Chronic heart failure;
• Diseases that occurred against the background of an acute infarction;
• Diabetic nephropathy;
• Arterial hypertension;
• Chronic diffuse diseases of the kidneys.

Take Hartil without evidence for its use is not recommended. Since before prescribing the drug the doctor diagnoses the patient's condition, the presence of chronic diseases and contraindications. A separate intake of Hartil can cause serious side effects of the drug and only aggravate the patient's health.

[3], [4], [5], [6]

Release form

The form of the drug Hartil - tablets. In one package of tablets contains 2 blisters for 14 tablets or 4 blisters for 28 tablets. Please note that Hartil produces 1.25 and 2.5 active substances. Tablets are oval from white to yellow with a bevel. Also, Hartil produce 5 mg and 10 mg, in this case the tablets can have a pink color and an oval shape.

The dosage of Hartil is selected by the doctor, individually for each patient. It is not recommended to take this medication independently. Since incorrectly chosen dosages can lead to uncontrolled and irreversible adverse reactions.

[7]

Pharmacodynamics

Pharmacodynamics Hartil is based on the work of the active substances of the drug. Active substance Hartil - ramipril, inhibits ACE, which causes an antihypertensive reaction. The drug reduces the level of angiotensin, which leads to a decrease in the secretion of aldosterone. Ramipril affects the process of blood circulation in tissues and vascular walls. With long-term administration of the drug, ramipril causes complications and diseases in patients with hypertension.

The use of ramipril significantly lowers the pressure of portal hypertension in the portal vein, slows down microalbuminuria, and in patients with diabetic nephropathy worsens the state of renal function.

[8], [9], [10]

Pharmacokinetics

Pharmacokinetics Hartil is the processes that occur with the drug after ingestion, that is, absorption, distribution, metabolism and excretion. After taking Hartil, the drug is quickly absorbed by the gastrointestinal tract and reaches a maximum concentration in the blood plasma after 1-1.5 hours. The degree of absorption of the drug is at the level of 60% of the administered dose. Hartil is metabolized in the liver, forming active and inactive metabolites.

Note that the active substance Hartil ramipril has a multi-phase pharmacokinetic profile. After applying the drug, about 60% are excreted in the urine, and the remaining 40% with feces, while about 2% of the drug is excreted unchanged. If the drug is taken by patients with renal insufficiency, then the rate of its elimination is significantly reduced. A decrease in enzymatic activity in the violation of liver function leads to the fact that the slowing down of the processing of the active substance Hartil in ramiprilate. This may cause a rise in the level of ramipril and cause symptoms of an overdose.

[11], [12], [13]

Dosing and administration

The way of application and dose of the drug depends on the disease and its symptoms. In addition, the use of the drug depends on the availability of contraindications, the age of the patient and other individual characteristics of the body. The drug is taken orally, and the intake does not depend on the time of eating. Tablets are not recommended to chew, they are washed down with a copious amount of water. The dosage of the drug is determined according to the tolerability of Hartil and the desired therapeutic effect.

• With arterial hypertension take 2.5 mg Hartil once a day. Term of treatment is from 7 to 14 days.
• In the treatment and prevention of heart failure take 1.25 mg Hartil once a day. Term of treatment is selected individually, but does not exceed 3 weeks.
• Treatment after myocardial infarction involves taking 2.5 mg of Hartil per day, for 3-10 days.
• In the treatment of nephropathy (diabetic and nondiabetic) take 1.25 mg of Hartil per day. Treatment takes place for 5-10 days.

When taking Hartil elderly patients, patients with kidney failure, impaired renal function and with diuretic therapy, the dose of the drug is selected individually.

[19]

Use Hartil during pregnancy

The use of Hartil during pregnancy is contraindicated. The active substance of the drug disrupts the development and formation of kidneys in the fetus, lowers blood pressure, leads to hypoplasia and deformity of the child's skull. It is strictly forbidden to take Hartil in the early stages of pregnancy, since taking the drug is a direct threat to the life of the child. In many patients, Hartel in the first trimester caused miscarriages and bleeding.

In the second trimester, medication is possible, then only for medical reasons. In this case, a woman should understand that treatment with Hartil is a direct threat to the normal development of her unborn child. Long-term use of the drug in the second trimester is the cause of intoxication of the fetus. If you take the drug in the last trimester of pregnancy, it will lead to fetal and placental ischemia, cause delays in the growth and development of the child. Women who take Hartil during pregnancy should undergo an ultrasound examination to check the condition of the skull and kidneys in the child.

Hartil is forbidden to take during lactation. The active substance of ramipril is excreted in breast milk. In addition, taking the drug causes a cessation of milk production. In this case, treatment is carried out with safer analog drugs and refuses breastfeeding.

Contraindications

Contraindications to the use of Hartil are based on individual intolerance of the active substance of the drug. The drug is forbidden to take during pregnancy and lactation, in the presence of chronic diseases and a number of other symptoms that the doctor can determine. Let's consider the main contraindications to the use of Hartil.

• Pregnancy and lactation;
• Hypersensitivity to ramipril and other components of the drug;
• Renal failure;
• Chronic liver disease;
• Stenosis of the renal arteries;
• Unstable hemodynamics.

With special care, the drug is taken with mitral stenosis, since there may be an excessive decrease in blood pressure. The drug is not recommended for patients who are on dialysis, as there is no exact information on how Hartil affects the body today.

[14], [15], [16]

Side effects Hartil

Side effects of Hartil can arise due to drug overdose, hypersensitivity to the active ingredient Hartil and in the presence of contraindications. Let's look at the main symptomatology of side effects when taking this medication.

• Reduction of blood pressure;
• Myocardial ischemia;
• Headache and dizziness;
• Insomnia, weakness, fainting;
• Violations of the vestibular apparatus;
• Disturbances of smell, sight, hearing and taste;
• Bronchospasm and cough;
• Nausea, diarrhea, vomiting;
• Stomatitis;
• Cholestatic jaundice;
• Allergic reactions to the skin;
• Reduction of hemoglobin concentration;
• Vasculitis;
• Change sweating and seizures;
• Neurogenic and other symptoms.

When there is side effects Hartil, you need to stop taking him and seek medical help.

[17], [18]

Overdose

Overdose Hartil arises with the use of high doses of the drug and long-term use of the drug. The main symptoms of overdose are expressed as low blood pressure, violation of water-electrolyte balance, bradycardia, renal failure.

With a mild overdose, Hartil rinses the stomach and takes adsorbents. If symptoms of acute overdose need to seek medical help. In this case, vital functions are maintained and monitored, as well as symptomatic therapy.

[20], [21]

Interactions with other drugs

Interaction Hartil with other drugs is carried out for medical reasons. Thus, the use of Hartil with corticosteroids, cytostatics causes blood changes and increases the possibility of disorders in the hematopoiesis system. In the interaction of Hartil with insulin and derivatives of sulfonylurea, that is, antidiabetic drugs, a sharp and dangerous decrease in blood sugar levels occurs. This is due to the fact that the active substances Hartil increase the sensitivity of the body to insulin.

When treating with the use of the drug Hartil, it is recommended to abandon the use of alcohol, since the drug increases the effect of alcohol. Any drug interactions with Hartil should be monitored by the attending physician to avoid side effects.

[22], [23], [24]

Storage conditions

The storage conditions of Hartil should be in accordance with the recommendations given in the instructions for the preparation. Hartil must be stored in a dry, cool place, which is protected from sunlight and not accessible to children. Storage temperature should not exceed 25 ° C.

Non-observance of storage conditions leads to damage to the drug and loss of its medicinal properties. If the storage conditions are not respected, Hartil also changes its physical properties - color, smell and other.

[25]

Shelf life

The shelf life of Hartil is two years, that is 24 months from the date of production, which is indicated on the package of the preparation. After the expiry date of the drug should be discarded. Since the use of overdue Hartil can lead to irreversible consequences and to the appearance of symptoms of an overdose.

[26]