Hartyl-N

Hartil-N is a medicine used to treat and prevent cardiovascular diseases. Let's look at the features of this medicine, indications for use, dosage, methods of use, contraindications and possible side effects.

Hartil-N is available in tablet form of 2.5 and 12.5 mg. The medication has two active ingredients - ramipril 2.5 mg and hydrochlorothiazide 12.5 mg. In addition to the active ingredients, the medication contains such components as: crospovidone, sodium stearyl fumarate, lactose monohydrate and others. Hartil-N is available by prescription, and when using it, it is necessary to strictly adhere to the dosage and time of taking the medication.

Hartil-N is a highly effective drug used to treat and prevent cardiovascular diseases. The drug is valued for its effectiveness and the ability to be used with other drugs that are part of the treatment complex. The drug is available on prescription. The dosage and duration of use are also regulated by the attending physician.

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Indications Hartyl-N

Main indications for the use of Hartil-N:

• Arterial hypertension
• Heart diseases and disorders
• Prevention of infarctions (myocardial)
• Prevention for patients with hemodynamics
• Early stages of diabetic and non-diabetic nephropathy
• Cardiovascular disorders
• Prevention and treatment of cerebral circulation problems.

Hartil-N should be taken every morning with plenty of liquid. The dose is prescribed to each patient individually, based on the disease and current symptoms. Please note that taking the medication does not depend on food intake. If the medication is prescribed to elderly people or patients with various chronic diseases, then medical supervision of the patient's condition is mandatory before use. Since very often, such patients experience adverse reactions to Hartil-N.

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Release form

Release form – tablets. Each pack of the medicine contains two blisters with 14 tablets each. That is, one package of Hartil-N is designed for a month of treatment. In some cases, patients are prescribed half a tablet, in which case they use Hartil-N packages of 14 tablets, that is, one blister.

Please note that the medicine is produced in cardboard packages, so it is almost impossible to check the authenticity of the medicine. To confirm the quality, you can request a certificate of conformity and a license. This is a guarantee that you will have real Hartil-N in your hands.

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Pharmacodynamics

Pharmacodynamics are the processes that occur with the medicine as soon as it enters the human body. The combination of two active substances, the diuretic hydrochlorothiazide and ramipril, has a diuretic and antihypertensive effect on the body. Three hours after taking the medicine, it reaches its maximum effect, which can last for a week after the end of the intake.

The active components of the medicine complement each other's action and quickly produce a therapeutic effect. Long-term use of Hartil-N leads to an exacerbation of chronic liver and kidney diseases. Therefore, taking the medicine should be strictly controlled.

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Pharmacokinetics

Pharmacokinetics is the process of distribution, absorption and excretion of the drug. The maximum concentration of active components of Hartil-N is observed in the blood plasma an hour after administration, and the drug is absorbed in the gastrointestinal tract. Binding to blood proteins is at the level of 75%. And it is metabolized in the liver, forming metabolites (active and inactive).

As for the excretion of Hartil-N, more than 60% is excreted as metabolites in the urine, and the remaining 40% in the feces. The half-life is from 5 to 15 hours, the therapeutic effect is observed two hours after administration, and the maximum within three hours. The action of the active components of the drug, as a rule, lasts about 24 hours. But the optimal therapeutic result can be observed after 3-4 weeks of treatment with Hartil-N.

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Dosing and administration

The method of administration and dosage of the medicine are prescribed by the doctor and depend entirely on the symptoms of the disease and the patient's condition. But regardless of this, the drug must be taken every morning with plenty of water. The use of the drug does not depend on food intake. Let's consider the features of application and dosage.

• The dosage of each active component is selected individually for each patient. The initial dose of the drug is 2.5 mg of ramipril and 12.5 mg of hydrochlorothiazide. If the patient is prescribed a maintenance dose, the amount of the first drug is increased to 5 mg, and the second to 25 mg. In some cases, the dose of the drug may be 10 mg of ramipril and 50 mg of hydrochlorothiazide. But the maximum safe dose is considered to be 5 mg of ramipril and 25 mg of hydrochlorothiazide.
• If the drug is prescribed to patients with kidney disease, the dose should be minimal, since there is a high probability of side effects and overdose symptoms. The maximum permissible dose is 5 mg of ramipril and 25 mg of hydrochlorothiazide.
• The drug is prohibited for use by patients who suffer from severe liver dysfunction or cholestasis. The dosage of the drug should be minimal, and its use should be monitored by the attending physician.

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Use Hartyl-N during pregnancy

The use of Hartil-N during pregnancy is not recommended. The first trimester is the riskiest period for taking the medication, as Hartil-N can lead to irreversible consequences. If taking the medication cannot be stopped for medical reasons, it is recommended to switch to safer analogues of Hartil-N. Please note that it is also better to refuse the medication when planning a pregnancy.

The drug is prohibited to take in the 2nd and 3rd trimesters. Since it can lead to intoxication of the fetus, suppression of kidney function, delays in ossification of the skull bones and oligohydramnios. It is necessary to refuse to take the drug during breastfeeding, since the drug can cause renal failure, hyperkalemia or hypotension in the baby.

Contraindications

Contraindications for the use of Hartil-N depend on the individual characteristics of the body and the reaction to the action of the active components of Hartil-N. So, the main contraindications for use:

• Hypersensitivity to the components of the drug
• Pregnancy and breastfeeding period
• Impaired renal function, anuria
• Angioedema
• Cholestasis, liver dysfunction.

Before prescribing a medicine to a patient, the doctor diagnoses the body for possible contraindications and side effects. In case of contraindications, the patient is prescribed a smaller dose of the medicine or is selected analogs of Hartil-N.

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Side effects Hartyl-N

Side effects occur if the dosage of the drug, the rules of administration were not observed, or the patient has an individual intolerance to one of the active components of Hartil-N. Let's look at the side effects of the drug:

• Syncope
• Arrhythmia
• Cerebral circulatory disorders
• Nausea and vomiting
• Bronchitis and dry cough.
• Sleep disturbances and dizziness
• Allergic reactions on the skin
• Leukopenia and edema
• Impaired kidney function and other symptoms.

If any of the above side effects occur, you should stop taking the medicine and seek medical attention.

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Overdose

Overdose of Hartil-N is possible if the dosage is prescribed incorrectly or if patients with the above contraindications start taking the drug. Let's look at the main symptoms of overdose of Hartil-N.

• Cardiac arrhythmia
• Cramps
• Urinary retention and swelling
• Intestinal obstruction
• Impaired consciousness and other symptoms.

In order to eliminate the symptoms of overdose, the patient undergoes gastric lavage, and immediately after the symptoms of overdose, sorbents are given (sodium sulfate or activated carbon). If angioedema occurs, the patient must immediately be given 0.5 ml of epinephrine or antihistamines.

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Interactions with other drugs

Interactions with other drugs are quite possible, but should be selected by the attending physician. Let's look at common drug interactions and possible side effects from their use

• The use of Hartil-N and indomethacins or acetylsalicylic acid may lead to a decrease in the hypotensive effect of the drug.
• With antihypertensive drugs and analgesics leads to antihypertensive effects of Hartil-N.
• The risk of leukopenia occurs when used with immunosuppressants.
• Interaction with insulin and any other hypoglycemic agents increases the risk of hypoglycemia. Very often, this symptom is diagnosed in the first weeks of combined use of Hartil-N and other drugs.

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Storage conditions

Storage conditions must comply with the instructions specified in the drug instructions. Hartil-N, like other tablets, is recommended to be stored in a dark place, protected from sunlight and children. The temperature should not be below 25 °C. Tablets are recommended to be stored in the original packaging.

If you do not comply with the storage conditions of Hartil-N, this will cause the loss of its medicinal properties. In addition, due to non-compliance with the storage conditions of Hartil-N, the drug may change its color and acquire an unpleasant odor. In this case, the tablets must be disposed of, since their use can lead to uncontrolled reactions of the body.

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Shelf life

The expiration date of Hartil-N is indicated on the packaging of the drug and is 36 months. After the expiration date, the drug is prohibited to be taken. The drug should not be taken if the storage conditions are not met.

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