Haloperidol decanoate

Haloperidol decanoate belongs to the number of antipsychotics. It can be attributed to the derived form of butyrophenone. He is able to have a pronounced antipsychotic effect. This is due to blockade of depolarization or a decrease in the degree of excitation of dopamine neurons. This medication is widely used in mental disorders. 

[1], [2], [3], [4]

Indications Haloperidol decanoate

Indications for the use of haloperidol decanoate are that the drug is used for severe schizophrenia. It is prescribed as maintenance therapy. Especially in those cases when ordinary haloperidol was previously used as a therapeutic action.

This form of medication is strengthened and is able to support a person during periods of severe seizures. Completely get rid of the disease is impossible, but partially improve the patient's condition completely.

The medication is prescribed in cases when a person suffers from severe mental disorders. Often they are accompanied by hallucinations, increased aggression and excitability.

Medication belongs to the number of antipsychotic prolonged action. He is able to have a powerful antipsychotic effect and moderate sedative effect. He can block dopamine receptors in the central nervous system. Haloperidol decanoate is able to provide analgesic, anticonvulsant, antiemetic and antihistamine action. 

[5], [6]

Release form

The form of the tablet is white and almost white. They have a rounded shape with a bevel. The smell is practically nonexistent. On one side of the tablet there is an engraving "I | I". The tablet contains 1.5 mg of haloperidol. Auxiliary substances of the drug are corn starch, gelatin, lactose, potato starch and talc.

The solution for intravenous and intramuscular administration is colorless or slightly yellowish. In one ampoule contains 5 mg of active substance. Lactic acid and water serve as auxiliary components.

Clinico-pharmacological group of medicament is a neuroleptic. The remedy is effective in both cases. It has a positive effect, both in the form of tablets and solution for administration. In this case, it is up to you to decide which type of issue to give preference.

It is important to get acquainted with the basic characteristics of the drug. This will determine whether the tool is suitable or not and understand when a person is in a fake. How to use the medicine Haloperidol decanoate should be decided by the attending physician. 

[7], [8], [9]

Pharmacodynamics

Pharmacodynamics of the drug is represented by the fact that it belongs to the number of antipsychotic prolonged action. He is able to have a pronounced antipsychotic effect. In addition, the medication helps to calm down and has good sedative properties.

The drug actively blocks dopamine receptors that are in the central nervous system. Medication is able to have a powerful antiemetic effect. It also eliminates heat and narrows the vessels.

This medication can be classified as one that has a wide effect. After all, it helps not only to relieve a person's condition, but also to save him from unpleasant symptoms caused by mental disorders.

That the medicine really helped, it is necessary to apply it correctly. Otherwise, the situation can significantly worsen. Therefore, a doctor's consultation is a forced measure. To take Haloperidol decanoate, you need to know enough about this medication and most importantly, apply it correctly.

[10], [11], [12]

Pharmacokinetics

Pharmacokinetics of the drug is that it reaches its full equilibrium concentration only after 2-3 months. In this case the medicine should be re-introduced.

Haloperidol decanoate is one of the antipsychotics that have a prolonged effect. Due to its active components, it has a pronounced antipsychotic effect. A person begins to feel relief in a short time. The main thing is to constantly support the patient with the help of a medication.

The possibility of blocking dopamine receptors in the central nervous system leads to the fact that the drug can have a pronounced antiemetic effect. In addition, it has antipyretic, antihistamine, analgesic and anticonvulsant functions. This is enough to make a person feel better.

Periodic seizures bring a lot of inconvenience to the patient and to the people around him. Therefore, taking haloperidol decanoate is necessary, it will help to transfer these processes, much easier. 

[13], [14], [15], [16],

Dosing and administration

To achieve the correct effect, it is important to know the method of administration and dose of haloperidol decanoate. So, the medicine is administered orally and intramuscularly. Duration of treatment depends on the individual characteristics of the body and how the disease progresses.

Dosage is selected in a similar way. During the calculation of this point, you need to take into account the doses of the medication itself and other medications that are used as an additional remedy. It is desirable that the combination be the same. Much depends on what drug was taken before the haloperidol decanoate. After all, most likely the concentration of the previous drug in the blood plasma is still preserved.

This drug is administered at a dose of 50-200 mg once every 4 weeks. It is a drug that is designed to maintain a person's condition, after a timely treatment. It does not need to be taken continuously. But, again, much depends on the state of man. In general, Haloperidol decanoate is able to help, but not solve the problem completely. 

[20], [21], [22], [23], [24]

Use Haloperidol decanoate during pregnancy

The use of haloperidol decanoate during pregnancy is not permissible. The fact is that such an effect can adversely affect the development of the fetus. It is especially dangerous to take the remedy in the early stages of pregnancy. The mother's body is significantly weakened, the immune system does not perform protective functions. This is a favorable environment for the penetration of various infections.

Therefore, the reception of strong drugs is prohibited. This can aggravate the situation. If a woman should take the medicine during pregnancy, you need a doctor's consultation.

During breastfeeding it is recommended to cancel the use of the medicine. After all, together with milk, active ingredients can penetrate the baby's body. In the first months of life this is simply an unacceptable interference. This can lead to the development of health problems that are irreversible. Reception The haloperidol decanoate should be administered under the supervision of a physician. But still, it is recommended to find an alternative way to solve the problem. 

Contraindications

Contraindications to the use of haloperidol decanoate are the presence of some health problems. Thus, neurological diseases are included among them, which may be accompanied by pyramidal and extrapyramidal symptoms.

The risk group includes pregnant women and young mothers who breastfeed. The penetration of active components into the body during this period is unacceptable.

These factors should be considered when it is necessary to take the medicine. In some cases, by adjusting the dose, it turns out, continue or start using the medication. But this is possible only in exceptional moments.

Neglect the basic rules is not worth it. After an independent increase in the dose, taking the medicine with its prohibition can lead to the development of serious problems. That's why a person suffering from mental disorders should use haloperidol decanoate under someone's guidance. This can save his life and protect him from wrong actions. 

Side effects Haloperidol decanoate

Side effects of haloperidol decanoate are represented by various manifestations from the central nervous system. Basically she suffers. So, there may be extrapyramidal disorders. They manifest themselves in the form of increased muscle tone, akinesia and tremor.

It is not excluded the appearance of tardive dyskinesia, it arises only against the background of long-term use of the drug. The expressed sedative effect also concerns to number of side effects. Depression can develop.

Other adverse effects include a reversible increase in serum prolactin levels. Usually this occurs when taking a large amount of medicine. This factor will change for the better independently.

If you do everything as written in the instructions, and do not take the drug in elevated doses, then there can not be any side effects. In this case, the medicine will have the necessary action and will not harm the body. Therefore, consultation regarding haloperidol decanoate is the main criterion. 

[17], [18], [19]

Overdose

Whether there is an overdose of Haloperidol decanoate and than it is caused? It's just that this phenomenon never occurs. Most likely, the matter is in increasing the dose or improperly taking the drug.

The main symptoms of overdose are the manifestation of rigidity of the muscles and local tremor. In some cases, arterial hypotension manifests itself, sometimes arterial hypertension and drowsiness. With an extremely complicated overdose, it is possible to develop a coma, shock and respiratory depression.

Treatment is based on the procedure of ventilation. To improve blood circulation, you must inject intravenously plasma, albumin solution and norepinephrine.

Adrenaline in this case can not be accepted! This can lead to serious problems. To reduce the severity of extrapyramidal disorders, it is worth using antiparkinsonics for several weeks. This will remove all the unpleasant symptoms that can cause haloperidol decanoate. 

[25], [26]

Interactions with other drugs

Naturally, interactions with other drugs are possible, but you need to know some rules for this. Thus, it is not recommended to use haloperidol decanoate together with antihypertensive drugs. This can lead to increased action of the latter.

A similar situation develops with barbiturates, antidepressants and opioid analgesics. If you use them together with this drug, then there may be a decrease in the effect of indirect anticoagulants.

If a person takes other drugs in parallel, you need to consult a doctor on the topic. After all, it is quite possible that medicines will strengthen each other's action, which will lead to serious health problems.

In no case should you take several drugs of a similar effect. This can lead to an overdose, especially in cases where the medicines have the same composition. Such interaction is unacceptable. Before taking Haloperidol Decanoate with other medications, it is worth consulting with a doctor. 

[27], [28]

Storage conditions

Storage conditions Haloperidol decanoate must be strictly observed. So, the drug should be stored in a place protected from light. The optimum temperature is 5-10 degrees. It should be noted that in this case the drug can be influenced by cold. In many cases, this is also unacceptable.

During storage of a medicine it is necessary to lean against some requirements. Despite the fact that the drug is stored in the cold, it can not be frozen. After such a process, it becomes unsuitable for use.

It is important to find a dry and dark place to store the medicine. In principle, even a refrigerator with a certain temperature regime is suitable. This will protect the product from direct sunlight. The only drawback, children can get to the drug. Therefore, it is advisable to think about this point, so that they do not accidentally take the remedy. Such simple rules will allow to store Haloperidol decanoate for a long time and at the same time its useful properties will not be lost. 

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Shelf life

Shelf life of the drug directly depends on the storage conditions. These two criteria simply can not exist separately. After all, if the medicine is not stored under the proper conditions, the expiry date becomes an ordinary figure and nothing more.

For the drug, optimal storage will be staying in the refrigerator. Because unlike other medications, for this purpose the best temperature is 5-10 degrees. But while freezing the product, in no case it is impossible.

It is important that children do not have access to the medicine, because taking the drug kids can cause serious disruption in their body. Therefore, the cold store is not always suitable for this. It can be a pantry or a cellar. But constantly lowering the medication is also uncomfortable.

It is desirable that the place is not illuminated, and it was dry. Such conditions will allow to maintain the viability of the drug for 3 years. Haloperidol decanoate, if used correctly, will not harm the person, but on the contrary will provide the necessary relief. 

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