After parenteral infusion, the bioavailability level of the drug is 100%. The parameters of the preparation are not the same as those of a standard molecularly homogeneous component, but are more similar to the characteristics of a mixture of several separate elements that differ in molecular weight, and the degree of substitution. Therefore existing now generally accepted rules of pharmacokinetic parameters can be applied to Hack only with great limitations, because its properties are constantly changing over time.
In persons taking the medicine, the most important in the process of assessing the indices of the replacement volume of the circulating blood inside the body is the time interval during which support is provided for the effects of replenishment of this volume achieved with the help of the HES substance. Therefore, when comparing drugs, it is allowed to use the indices of the duration of the presence of plasma substitutes inside the body (this is expressed as the initial half-life - provided that there are no differences in the measurement intervals, and in addition to the dosage of the infusion and its circulation).
The initial half-life of the substance from the blood serum depends on the type of infusion and the rate of its administration, and is approximately 5-7 hours.
Molecules of the HES element, having a size smaller than the elimination threshold, are excreted by the kidneys, by filtering the glomeruli. With a single use of a dosage of 500 ml, about 50% of the injected drug is detected inside the urine in a period of 24 hours.