Glutargine

Glutargin is a hepatoprotective agent designed to protect and maintain liver function. The main active ingredient in Glutargin is arginine glutamate.

Arginine glutamate is a combination of two amino acids: arginine and glutamate. Both of these substances play an important role in the body. Arginine helps remove toxins from the liver, improves blood supply and accelerates the regeneration of liver cells. Glutamate, in turn, is an important component of many metabolic processes, including those in the liver.

Glutargin is commonly used to prevent and treat various liver diseases, such as fatty degeneration, hepatitis, cirrhosis, and others. It helps improve liver metabolism, reduce toxic levels, and promote liver recovery and protection from harmful factors.

Indications Glutargine

1. Fatty liver disease (steatosis).
2. Chronic and acute forms of hepatitis of various etiologies.
3. Cirrhosis.
4. Toxic liver damage caused by alcohol, drugs, chemicals and other factors.
5. Prevention and treatment of intestinal dysbacteriosis.
6. Liver restoration after surgery and radiation therapy.

Release form

Glutargin is usually produced as a solution for intravenous administration. It can be supplied in ampoules or vials of various sizes, usually in arginine glutamate concentrations of 100 mg/ml or 500 mg/ml.

Pharmacodynamics

1. Amino Acid Metabolite: Arginine glutamate is a metabolite that is involved in various metabolic processes in the body. It plays an important role in amino acid metabolism, energy metabolism and other metabolic pathways.
2. Liver support: Glutargin helps protect and restore liver function through its complex action. It can help reduce inflammation, stimulate liver cell regeneration, and protect liver cells from damage.
3. Antioxidant action: Arginine glutamate has antioxidant properties, helping to neutralize free radicals and protect liver cells from oxidative stress, which can be caused by various toxic substances or pathologies.
4. Stimulation of amino acid metabolism: Glutargin may help improve amino acid metabolism in the liver, which in turn may increase protein synthesis and improve overall liver health.
5. Improved Metabolic Function: Glutargine use may help improve the liver's metabolic functions, including the processing and utilization of fats, carbohydrates, and other nutrients.
6. Protection from toxic influences: Glutargin can help protect the liver from various toxic influences such as alcohol, drugs, heavy metals and other substances.

Pharmacokinetics

1. Absorption: Arginine glutamate is generally well absorbed from the gastrointestinal tract after oral administration. It can quickly and easily penetrate the intestinal wall due to its low molecular weight.
2. Distribution: After absorption, arginine glutamate is distributed throughout the body through the blood. It can penetrate the blood-brain barrier and provide the desired effect in cells and tissues.
3. Metabolism: Arginine glutamate can be metabolized in the body through various metabolic pathways, including hydrolysis, oxidation, and amidation. Metabolites can be formed and then excreted via the kidneys or bile ducts.
4. Excretion: Most arginine glutamate metabolites are excreted from the body via the kidneys in the urine or via the biliary tract in the feces.

Dosing and administration

The hepatoprotective agent Glutargin, containing arginine glutamate, is usually used as intravenous injections. The dosage may vary depending on the patient's condition, disease characteristics and doctor's recommendations. It is usually recommended to use 5-20 ml of Glutargin solution per day, administered intravenously slowly, by drip.

The exact dosage and treatment regimen should be determined by the physician on an individual basis in accordance with the clinical picture and characteristics of the patient.

Use Glutargine during pregnancy

Glutargine, which contains arginine glutamate, is generally not recommended for use during pregnancy without consulting a doctor. Information about its safety during pregnancy may be limited, and potential risks to the baby may not be well understood.

Contraindications

1. Known Allergy: Patients with a known allergy to arginine glutamate or other components of the drug should avoid its use.
2. Severe renal and hepatic impairment: The use of Glutargin may be contraindicated in patients with severe renal and hepatic impairment, as this may lead to accumulation of the drug in the body and deterioration of the condition.
3. Amino acid metabolism disorders: In patients with rare hereditary disorders of amino acid metabolism (eg, arginine glutamate), the use of Glutargin may be contraindicated and requires caution under medical supervision.
4. Pregnancy and breastfeeding: There is limited information on the safety of Glutargin during pregnancy and breastfeeding, so its use requires consultation with a doctor.
5. Children and adolescents: Data on the safety and efficacy of Glutargin in children and adolescents may be limited, so its use in this category of patients requires special caution and medical supervision.

Side effects Glutargine

1. Rarely, allergic reactions such as itching, rash, redness of the skin and even anaphylactic shock occur in individuals with hypersensitivity to the components of the drug.
2. In rare cases, dyspeptic disorders (vomiting, diarrhea, nausea, abdominal pain) may occur.
3. An unpleasant taste in the mouth may occur.
4. Elevated blood ammonium levels (hyperammonemia) in some patients with absolute deficiency of one of the urea cycle enzymes.
5. Hyperazotemia may occur when high doses are used.
6. The acidity level in the stomach may increase.
7. Rarely, hematopoietic disorders may occur.

Overdose

1. Gastrointestinal disorders: Diarrhea, nausea, vomiting, bloating or abdominal pain may occur.
2. Electrolyte Imbalances: Excessive consumption of amino acid supplements can lead to electrolyte imbalances in the body, especially if there is high sodium or potassium intake.
3. Increased Blood Ammonium: Arginine glutamate may increase blood ammonium levels, especially in the presence of amino acid metabolism or liver function disorders.
4. Acid-base imbalance: It is possible that disturbances in the acid-base balance of the body may occur.
5. Allergic reactions: Some people may experience an allergic reaction to amino acids, including skin rash, itching, swelling, or anaphylactic shock.

Interactions with other drugs

Interactions of the hepatoprotective agent Glutargin with other drugs may be limited due to the lack of significant interaction data. However, given that Glutargin contains arginine glutamate, which is a natural amino acid compound, interactions may be minimal.

Storage conditions

Typically, hepatoprotective drugs, including Glutargin, are stored in a dry place at room temperature (15°C to 25°C), away from direct sunlight and moisture. Storage conditions may vary slightly depending on the specific manufacturer and form of release of the drug, so it is recommended to refer to the instructions for use or packaging for specific information on storing Glutargin.