Gepalin

Hepalin is a drug with hepatotropic properties.

Indications Hepalina

It is used in the following disorders:

• fatty liver infiltration;
• hepatitis in the chronic stage, having a different nature;
• violation of biliary activity ( dyskinesia in the gallbladder, which has a hypotonic form);
• IBS, accompanied by constipation;
• therapy and prevention of anorexia associated with stress, disease and other negative factors.

Release form

The release of the substance produced in the form of a syrup, in bottles with a capacity of 0.2 liters.

Pharmacodynamics

Choline citrate effectively and in a short time restores indicators of choline inside the body, and at the same time improves the processes of magnesium absorption. It is an integral part of phospholipids and is involved in most biological processes. Also, choline is included (as the main element) in the polar category of phosphatidylcholine (this component helps to preserve the integrity of the cell walls). In addition, the substance is the main component of another membrane phospholipid - a component of sphingomyelin, which is also a participant in the processes of maintaining cell structure.

Sorbitol is needed in cases where additional energy is urgently needed. The second part of the substance in the form of glycogen is set aside as a spare. Isotonic liquid from sorbitol has a disaggregating effect, thereby improving tissue perfusion along with microcirculation.

Pharmacokinetics

Choline citrate is absorbed inside the small intestine. A small part of the drug undergoes intrahepatic metabolism, resulting in the formation of the components trimethylamine and betaine. Choline undergoes accumulation within all tissues of the body. Excretion occurs through the kidneys.

Sorbitol in a short time is included in the general metabolic processes occurring inside the body. At 80-90% of the disposal of the substance takes place inside the liver, and cumulation occurs in the form of glycogen.

Dosing and administration

With maintenance treatment in case of disorder in the work of the digestive or hepatobiliary organs, as well as the liver:

• Adolescents over the age of 14 years old and adults should take 2 teaspoons of drugs (10 ml), which are pre-dissolved in plain water. Take the medicine before the meal;
• 3-8-year-old children prescribed 1-n teaspoon of the drug (5 ml);
• 9-13-year-old children are required to take 2 teaspoons of the drug (10 ml).

The use of the medication during stapipation:

• persons older than 14 years old - 2-4 teaspoons of medication (10-20 ml), which is dissolved in 1 cup of plain water. It is necessary to consume the substance before breakfast in the morning;
• children 3-8 years of age - taking 1 tsp of the substance (5 ml);
• Children 9-13 years of age - use 2 teaspoons of syrup (10 ml).

The duration of the therapeutic cycle is determined by the nature of the pathology and the effectiveness of the treatment.

Use Hepalina during pregnancy

Nursing mothers and pregnant drug is not prescribed.

Contraindications

Main contraindications:

• severe intolerance to the elements of the drug;
• cerebral hemorrhage or alkalosis;
• thromboembolism;
• decompensation affecting the work of the CAS;
• increased blood pressure in the 3rd stage.

Side effects Hepalina

Use of Gepalina can lead to symptoms of alkalosis. Occasionally, dyspeptic symptoms develop: diarrhea with nausea and gastric disturbances.

The use of large portions of the substance can lead to a decrease in blood pressure and the development of hyperhidrosis; development of depression was sometimes observed.

Overdose

With intoxication may develop signs of alkalosis. In such a case, you must immediately cancel the use of drugs. The treatment procedures are regulating acid-base indicators.

Interactions with other drugs

Methotrexate can reduce the accumulation of all the metabolic products of choline.

It is forbidden to combine Hepalin with liquids that contain carbonate with phosphate.

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Storage conditions

Gepalin should be kept in a place closed to small children. Temperature marks - within 25 ° С.

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Shelf life

Hepalin can be used within a 36-month period from the date the drug was manufactured.

Application for children

Do not use Gepalin for the treatment of children under 3 years of age.

Analogs

Analogues of the drug are Essentiale N, Hepel, Livolact and Essentiale Forte N with Esavit and Antral, and in addition Hepel N, Phosphogliv and Bicyclol.