Hepalin

Hepalin is a drug with hepatotropic properties.

Indications Hepaline

It is used for the following disorders:

• fatty liver infiltration;
• chronic hepatitis of various origins;
• disruption of biliary activity ( dyskinesia in the gallbladder area, which has a hypotonic form);
• IBS accompanied by constipation;
• therapy and prevention of the development of anorexia associated with stress, illness and other negative factors.

Release form

The substance is released in the form of syrup, in 0.2 l bottles.

Pharmacodynamics

Choline citrate effectively and quickly restores choline levels in the body, and at the same time improves magnesium absorption processes. It is a component of phospholipids and is involved in most biological processes. Choline is also included (as a main element) in the polar category of phosphatidylcholine (this component helps maintain the integrity of cell walls). In addition, the substance is the main component of another membrane phospholipid - a component of sphingomyelin, which is also involved in the processes of maintaining cell structure.

Sorbitol is necessary in cases where additional energy is urgently needed. The second part of the substance in the form of glycogen is deposited as a reserve. Isotonic liquid from sorbitol has a disaggregant effect, due to which it improves tissue perfusion together with microcirculation.

Pharmacokinetics

Choline citrate is absorbed in the small intestine. A small portion of the drug undergoes intrahepatic metabolism, resulting in the formation of components trimethylamine and betaine. Choline accumulates in all tissues of the body. Excretion occurs through the kidneys.

Sorbitol is quickly included in the general metabolic processes occurring within the body. 80-90% of the substance is utilized within the liver, and accumulation occurs in the form of glycogen.

Dosing and administration

For maintenance treatment in case of disorders in the functioning of the digestive or hepatobiliary organs, as well as the liver:

• adolescents over 14 years of age and adults should take 2 teaspoons of the medicine (10 ml), which are first dissolved in plain water. The medicine should be taken before lunch;
• Children aged 3-8 years are prescribed 1 teaspoon of the medicine (5 ml);
• Children aged 9-13 years are required to take 2 teaspoons of the medicine (10 ml).

Use of the drug in constipation:

• persons over 14 years of age - 2-4 teaspoons of the medicine (10-20 ml), which are dissolved in 1 glass of plain water. The substance should be consumed before breakfast in the morning;
• children aged 3-8 years – take 1 teaspoon of the substance (5 ml);
• Children aged 9-13 years – use 2 teaspoons of syrup (10 ml).

The duration of the therapeutic cycle is determined by the nature of the pathology and the effectiveness of the treatment.

Use Hepaline during pregnancy

The drug is not prescribed to nursing mothers and pregnant women.

Contraindications

Main contraindications:

• severe intolerance to the components of the drug;
• cerebral hemorrhage or alkalosis;
• thromboembolism;
• decompensation affecting the functioning of the cardiovascular system;
• increased blood pressure in stage 3.

Side effects Hepaline

The use of Hepalin may lead to the appearance of symptoms of alkalosis. Dyspeptic symptoms develop rarely: diarrhea with nausea and gastric disorders.

Use of large doses of the substance may lead to a decrease in blood pressure and the development of hyperhidrosis; sometimes the development of depression has been observed.

Overdose

In case of intoxication, signs of alkalosis may develop. In such a case, it is necessary to immediately stop using the drug. During treatment, procedures are carried out that regulate acid-base indicators.

Interactions with other drugs

Methotrexate is able to reduce the accumulation of all metabolic products of choline.

It is prohibited to combine Hepalin with liquids that contain carbonate and phosphate.

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Storage conditions

Hepalin should be kept in a place closed to small children. Temperature marks – within 25°С.

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Shelf life

Hepalin can be used within 36 months from the date of manufacture of the medicinal substance.

Application for children

Hepalin should not be used to treat children under 3 years of age.

Analogues

The analogues of the drug are Essentiale N, Hepel, Livolact and Essentiale Forte N with Esavit and Antral, as well as Hepel N, Phosphogliv and Bicyclol.