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Gepabel
Last reviewed: 23.04.2024
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Hepabel is used for various biliary diseases.
Indications Hepabel
It is used in the following disorders:
- dyskinesia in the field of GID, having a hypokinetic form;
- a boneless form of cholecystitis in the chronic stage;
- chronic hepatitis;
- hepatic cirrhosis ;
- failure of the kidney in a chronic degree;
- chronic nephritis ;
- chronic poisonings (with hepatotoxic elements, alkaloids, nitro compounds, or heavy metal salts).
Release form
The release of the medicinal component is implemented in tablet form, in the amount of 60 pieces inside a polypropylene jar.
Pharmacodynamics
Hepabel has a plant origin. Its therapeutic activity develops under the influence of a complex of bioactive components (such as bioflavonoids, cinnarine with glycosides, coffee, as well as chlorogenic acid, carotene with phytosterols, enzymes, terpenoids and vitamins with inulin) contained within the Spanish artichoke. The drug has hepatoprotective, diuretic, antioxidant, choleretic, detoxification and cholesterol-lowering activity.
The hypocholesterolemic effect develops when the cholesterol biosynthesis process is slowed down (by inhibiting the activity of 3-hydroxy-3-methylglutaryl-CoA reductase).
Cinnarine, combined with phenoacids, has choleretic activity (mainly with the participation of choleretic effects). It increases the amount of secreted bile, the secretion of gallic acid salts, and in addition it prevents the probability of stagnation of bile inside the gvp and potentiates the secretion of pancreatic enzymes.
Tablets have antioxidant properties; the drug reduces lipid peroxidation by decreasing malondialdehyde.
The hepatoprotective effect develops as a result of the stabilizing effect on the walls of hepatocytes.
Dosing and administration
For adults, the serving size is 1-well pill with 3 times daily use (the medicine should be taken 20 minutes before meals). Adolescents older than 12 years of age should use a 1-well tablet 2 times a day.
The therapeutic cycle lasts 10-20 days; if necessary, the doctor may prescribe the re-treatment after 1-2 months.
[1]
Use Hepabel during pregnancy
It is forbidden to use Gepabel during pregnancy or lactation.
Contraindications
Among the contraindications:
- the presence of hypersensitivity to the elements of the drug and plants from the group of the asteraceae;
- obstruction of the urethra or GVD;
- holelitiaz;
- diseases affecting the bile, and in addition the urinary ducts, liver or kidneys, and having an acute form;
- insufficiency of hepatic function, having a severe degree.
Side effects Hepabel
The use of the drug may be a factor in the development of disorders affecting the gastrointestinal tract: diarrhea (sometimes accompanied by spasms), nausea, pain in the upper abdominal area and heartburn.
People with a strong sensitivity to the elements of a therapeutic agent may develop signs of allergies.
Overdose
Cases of intoxication were not recorded. In case of overdose, potentiation of negative manifestations of drugs can be expected.
In order to eliminate the violations, you should cancel the medication and conduct gastric lavage with symptomatic procedures. The drug does not have an antidote.
Interactions with other drugs
The drug is able to reduce the effectiveness of coumarin anticoagulants (among those warfarin with fenprocoumon), because of which the dosage of the latter must be adjusted.
Combination with cholesterol or hypoazotemic drugs can increase the effectiveness of these drugs.
Hepabel has a diuretic effect, increases the secretion of chloride with sodium, and in addition it can potentiate the hyperuricemic and hyperglycemic effect of drugs that increase blood glucose values.
Storage conditions
Gepabel needs to be kept in a dark place, closed from small children. Temperature indicators - within the mark of 25 ° C.
[2]
Shelf life
Hepabel can be used within a 3-year period from the time the therapeutic drug is released.
Application for children
You can not prescribe medication in pediatrics (children under 12 years of age).
[3]
Analogs
Analogs of the medicinal substance are Rovakhol, Allohol, Tsinarix with Immortelle, as well as Holosas, Flamin and Hofitol.
Attention!
To simplify the perception of information, this instruction for use of the drug "Gepabel" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.