"Gatifloxacin" is an antibiotic of the 4th generation of fluoroquinolones, the therapeutic effect of which differs from other popular antibiotics of a narrow and broad spectrum of activity (penicillins, cephalosporins, tetracyclines, aminoglycosides, macrolides).
Reproduction of microorganisms occurs by dividing cells. In this process, enzymes of topoisomerase IV and DNA-gyrase, produced by the microorganisms themselves, are involved. Thanks to them, the chromosomes are divided, and the new cell gets the properties of the parent.
Gatifloxacin has the ability to inhibit the production of these enzymes, and the process of reproduction of pathogenic microorganisms is extinguished.
Gatifloxacin has a broad spectrum of antibacterial activity, and it is effective even against microorganisms that are insensitive to other types of AMP. For him, there is no cross-resistance with other antibiotics.
Bacteria that show sensitivity to gatifloxacin:
- Gram-positive - Staphylococcus aureus, pneumococcus, streptococcus piogenes ( the causative agent of tonsillitis, rheumatic fever, glomerulonephritis)
- gram-negative - hemophilic rod , Klebsiella pneumonia, moraxella cataris, E. Coli, enterobacter cloaca, gonococcal infection
They show relative sensitivity:
- gram-positive - streptococci (varieties: mileribus, mitis, agalactia, disgalaxy), staphylococcus (varieties: kohni epidermidis, hemolytic, saprophytic, hominis, simulans), corynebacterium (causative agent of diphtheria)
- Gram-negative - pertussis wand, oxytocell klebsiella (causative agent of inflammatory pathologies to the intestine and urinary system), enterobacteria (varieties: aerogenes, agglomerants, intermediate, sakazaks), proteus mirabilis and vulgaris, morganella providentia (rettgeri and stuartii).
Relative sensitivity to gatifloxacin is also evident in most anaerobes: bacteroides (varieties: distasonis, eggeri, fragilis, ovatus, thetaiotaomicron, uniformis), fusobacteria, porphyromonads (varieties: typical, anaerobius, magnus), prevotella, propionibacteria, clostridia (perfringens and ramosum).
Pathogens that are considered to be atypical and remain sensitive to gatifloxacin: clamamidia (pneumoniae and trachomatis are pathogens of out-of-hospital pneumonia and chlamydosis), mycoplasma pneumonia, ureaplasma.
Relatively sensitive are the legionella pneumophyll and the coxaeella Burnet (causative agents of pneumonia and ku-fever).
In bacteria resistant to beta-lactam AMP and macrolides, resistance to gatifloxacin does not develop.