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Health

Zarquin

, medical expert
Last reviewed: 03.07.2025
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The drug Zarquin belongs to the antibacterial and antiparasitic agents of the fluorinated quinolone group.

Other trade names: Gaflox, Gatimak, Gatibact, Gatispan, Ozerlik, Tebris.

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Indications Zarquin

Indications for use of Zarquin include treatment of pneumonia, acute and chronic bronchitis, acute sinusitis and conjunctivitis, phlegmon and subcutaneous abscesses, acute pyelonephritis and cystitis, gonococcal urethritis and endocervicitis, acute osteomyelitis and periostitis, tuberculosis, peritonitis, sepsis. The drug can be used in gastroenterology for eradication of Helicobacter pylori bacteria.

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Release form

Zarquin is available in tablet form (0.2 and 0.4 g).

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Pharmacodynamics

The pharmacodynamics of this drug is provided by the active substance - gatifloxacin sesquihydrate, which acts on gram-negative and gram-positive microorganisms that exhibit resistance to antibiotics of other pharmacological groups.

Zarquin affects bacteria by disrupting the replication of their DNA (inhibiting topoisomerase enzymes) and changing the structure of cell membranes, which stops cell division and the development of microorganisms, causing their death.

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Pharmacokinetics

Regardless of the form of release, Zarquin penetrates into many tissues and biological fluids of the body, as well as through the BBB, demonstrating bioavailability at the level of 96% and binding to blood plasma proteins - up to 20%. The maximum plasma concentration of the drug is noted 60-120 minutes after its use.

Biotransformation of gatifloxacin sesquihydrate is partial, at least 70% of the drug is excreted from the body unchanged. Elimination is via the kidneys (with urine) and intestines (with feces).

The half-life of the drug, independent of dose and route of administration, ranges from 7 to 14 hours.

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Dosing and administration

Zarquin tablets are taken orally - 0.2 g twice a day or 0.4 g once; the duration of use is determined by the doctor and can be from seven to ten days.

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Use Zarquin during pregnancy

The drug Zarquin is prohibited to be used during pregnancy and breastfeeding.

Contraindications

Contraindications to the use of Zarquin include allergic reactions to fluoroquinolone antibiotics and childhood. A relative contraindication is diabetes mellitus.

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Side effects Zarquin

Side effects of Zarquin include: headache, dizziness, urticaria, nausea, vomiting, diarrhea, inflammation of the mucous membranes, joint and muscle pain, fever, increased heart rate, hyperhidrosis, soft tissue swelling, vasodilation, tremor and paresthesia, sleep disturbances, decreased vision and increased lacrimation (when using eye drops).

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Overdose

In case of overdose of Zarquin, vomiting, tremors, convulsions occur; heart rate decreases, fainting and mental changes occur.

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Interactions with other drugs

Concomitant use of Zarquin with hypoglycemic agents, anticoagulants, antiarrhythmic and antipsychotic drugs is not permitted.

Zarquin potentiates the action of digitalis cardiac glycosides and also enhances the side effects of non-steroidal anti-inflammatory drugs.

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Storage conditions

Store in a place protected from light, at t< +25°C.

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Shelf life

2 years.

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Attention!

To simplify the perception of information, this instruction for use of the drug "Zarquin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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