Gastrosidine

"Gastrosidin" is another fairly effective drug that has found its application in the treatment of gastric ulcer and duodenal ulcer, as well as many other pathologies of the digestive system.

Indications Gastrosidine

Doctors recommend taking the drug "Gastrosidin" for the following diseases of the gastrointestinal tract:

• Gastric and duodenal ulcers. The drug is indicated both during periods of exacerbation and for the prevention of relapses of the disease.
• Ulcerative lesions of the gastrointestinal tract associated with active use of nonsteroidal anti-inflammatory drugs and the negative impact of stressful situations. The drug is used for both prevention and treatment of the above pathologies.
• Postoperative ulcers of the gastrointestinal tract (both for treatment and for prevention of the development of ulcerative processes).
• Erosive lesions of the stomach and duodenum (erosive gastritis or duodenitis, erosive esophagitis).
• Esophagoreflex disease of the stomach.
• Functional dyspepsia caused by increased secretion of gastric juice.
• Zollinger-Ellison syndrome, or gastrinoma (a tumor in the islet apparatus of the pancreas, causing increased secretion of gastrin, which in turn has an irritating effect on the gastrointestinal mucosa, stimulating uncontrolled secretion of pepsin and hydrochloric acid).

The drug has also found wide application as a prophylactic agent to prevent bleeding and its recurrence.

It is also used before operations performed under general anesthesia. It prevents aspiration of gastric juice, i.e. the reflux of acidic stomach contents into the pharynx and bronchi.

Release form

The drug "Gastrosidin" has 2 forms of release. The pharmaceutical industry produces the drug in the form of tablets of 10 pieces in a blister. (the drug package can contain 10 or 30 tablets) and lyophilisate for the preparation of an injection solution.

Pharmacodynamics

"Gastrosidin" belongs to the group of histamine H2-receptor blockers _. This is a drug from the 3rd generation of the above-mentioned drugs.

The main active ingredient is the well-known famotidine, which stands out among similar drugs due to the presence in its structure of a substituted thiazole ring, which has some antimicrobial activity.

The drug's action is aimed at suppressing the production of hydrochloric acid in the stomach. In this case, the production of hydrochloric acid decreases both at rest (basal secretion) and under the influence of gastrin, histamine and acetylcholine produced during food intake (stimulated secretion).

Under the influence of famotidine, a decrease in the activity of pepsin (another irritant to the mucous membrane) is also noted.

The drug provides protection of the gastrointestinal mucosa from aggressive factors that maintain an acidic environment in the stomach, and promotes the healing of erosive and ulcerative lesions of the internal part of the digestive organs.

The drug helps stop bleeding and prevents it in the future. Its action stimulates mucus formation in the stomach and the production of hydrocarbonate by its cells, due to which the regeneration of organ tissues occurs.

Pharmacokinetics

Oral administration of tablets ensures its action within the first hour. The maximum concentration of famotidine in the blood plasma is observed after 2 hours from taking the drug, and the half-life is 2.5-3 hours.

The bioavailability of the drug is slightly dependent on food intake and fluctuates within 40-50%. Famotidine is excreted mainly by the kidneys in its original form.

When the drug solution is administered intravenously, its effect begins after half an hour.

The antisecretory effect of the drug lasts for a long time (up to 1 day).

Dosing and administration

Gastrosidin tablets are intended for oral administration. They have a protective coating that is destroyed only by gastric juice. The tablets do not need to be chewed. When taking the drug, they are washed down with a glass of water.

Treatment of acute conditions of erosive and ulcerative lesions of the gastrointestinal tract is carried out using one or two times a day. The drug with a dosage of 20 mg is taken 2 times a day (morning and evening) 1 tablet. If the tablet contains 40 mg of the drug, it is taken only in the evening before bedtime. In severe cases, it is possible to increase the daily dosage to 160 mg. The course of treatment is from 4 to 8 weeks.

To combat dyspeptic symptoms associated with increased stomach acidity, tablets are taken in a daily dosage of 20-40 mg (1 or 2 doses).

The same dosage of the drug is prescribed for the treatment of esophagoreflex disease. For gastrinoma, tablets of 20 mg should be taken every 6 hours with the possibility of increasing the dose to the maximum permissible. The course of treatment for Zollinger-Ellison syndrome is from 6 to 12 weeks.

For prophylactic purposes, tablets are prescribed once a day. Daily dose is 20 mg.

Treatment of gastroesophageal reflux in children can be carried out using tablets (crushed and mixed with water) or lyophilisate. The dosage is calculated based on the patient's weight - 1 or 2 mg per kilogram of weight per day. The resulting dose is divided into 2 doses, and if the child's body weight is less than 10 kg - into 3 doses.

Intravenous administration of the drug is advisable when it is impossible to take the drug orally (gastric bleeding, early childhood) and during preoperative preparation. Lyophysilate is diluted in saline.

To prevent the reflux of stomach contents into the esophagus and respiratory tract, the drug is prescribed in the morning 2 hours before surgery in tablets (40 mg) or intravenously by jet stream (20 mg).

For ulcerative lesions of the gastrointestinal tract and increased secretion of gastric juice, 20 mg of the drug is prescribed every 12 hours. The drug is administered intravenously over 2 minutes.

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Use Gastrosidine during pregnancy

It is not advisable to take Gastrosidin during pregnancy, since the effect of famotidine on fetal development and the course of pregnancy has not yet been sufficiently studied.

There is information indicating the possibility of a small amount of the active substance penetrating into breast milk, so it is better to transfer the child to artificial feeding during treatment with the drug.

Contraindications

In addition to the fact that the use of "Gastrosidin" is not allowed during pregnancy and breastfeeding, there are other contraindications to the use of the drug. It is not prescribed:

• patients with liver failure,
• for children (in tablet form),
• in severe kidney pathologies.

Intolerance to one or more components of the drug is also an obstacle to therapy with Gastrosidin.

Particular caution is exercised when prescribing the drug to patients with liver cirrhosis, portosystemic encephalopathy, and renal and urinary system disorders.

Before prescribing a drug, it is necessary to make sure that the existing symptoms of gastric diseases are not associated with oncology (gastric carcinoma). Famotidine helps reduce the intensity of the symptoms of the disease, which makes it difficult to diagnose it at an early stage and allows it to move to a more severe stage.

Side effects Gastrosidine

The drug "Gastrosidin" can affect the functioning of the digestive, nervous, cardiovascular, reproductive and other systems of the human body. In this regard, some undesirable symptoms may be observed.

The digestive system may react to the drug intake with nausea, vomiting, loss of appetite and taste, dry mucous membranes of the mouth and throat, dyspeptic symptoms, constipation or diarrhea. In some cases, signs of cholestatic jaundice were noted, and the level of liver transaminases increased.

The nervous system may respond to taking the medication with headaches, tinnitus, fatigue and irritability.

From the cardiovascular system, disorders rarely manifest themselves in the form of arrhythmia, decreased blood pressure and heart rate.

The immune system may react with allergic reactions in the form of dry skin, rashes and itching. In rare cases of drug intolerance, symptoms such as bronchospasm, Quincke's edema, and anaphylaxis may appear.

Other possible symptoms: visual acuity and accommodation disturbances, changes in blood laboratory parameters, muscle and joint pain, fever, gynecomastia, menstrual pain, etc.

Overdose

An overdose of the drug is observed when taking the medicine in doses exceeding the permissible values. In this case, against the background of increased motor activity, a sharp decrease in blood pressure, nausea with vomiting attacks, trembling of the limbs, tachycardia are noted.

After gastric lavage and taking sorbents, symptomatic treatment is indicated.

Interactions with other drugs

It is not advisable to take Gastrosidin simultaneously with anticoagulants that increase the risk of bleeding, antacids based on magnesium and aluminum hydroxides that reduce the absorption of famotidine, and nifedipine due to the possible short-term negative effect on cardiac activity.

The interval between taking Gastrosidin and antacids should be at least 2 hours.

Probenecid can increase the concentration of famotidine in the blood, increasing the toxic effect on the liver.

"Gastrosidin" reduces the bioavailability of cefpodoxime by impairing its solubility at high pH levels of gastric juice.

The drug can increase the concentration of phenytoin and cyclosporine with an increase in their toxicity when taken in parallel. But the content of itraconazole, ketoconazole and norfloxacin in the blood decreases under the influence of famotidine, which negatively affects the therapeutic effect of these antimicrobial agents (the interval between drug intakes should be at least 2 hours).

The development of neuropenia is associated with the simultaneous use of Gastrosidin and drugs with a depressant effect on the bone marrow.

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Storage conditions

It is recommended to store the medicine at room temperature, avoiding exposure to direct sunlight and moisture.

Do not allow uncontrolled use of the drug by children and adolescents.

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Special instructions

The drug should be discontinued with a gradual reduction in dosage and frequency of administration.

"Gastrosidin" during long-term treatment can provoke the development of gastric bacterial infections in weakened patients.

During therapy with the drug, it is necessary to limit the intake of foods and drinks that irritate the gastric mucosa.

Special caution during therapy with the drug should be observed by patients with liver and kidney disorders. In this case, the doctor selects the appropriate doses of the drug and monitors the condition of the diseased organs.

Shelf life

The shelf life of any form of the drug "Gastrosidin", subject to compliance with the above requirements, is 4 years.