"Gastrosidin" is another rather effective drug that has found its application in the therapy of peptic ulcer of the stomach and duodenum, as well as many other pathologies of the digestive system.
Indications of the gastrosidine
Doctors recommend taking the drug "Gastrosidin" with such diseases of the digestive tract:
Ulcers of the stomach and duodenum. The drug is shown both during periods of exacerbation, and for the prevention of recurrence of the disease.
Ulcerous lesions of the digestive tract, associated with an active intake of non-steroidal anti-inflammatory drugs and the negative impact of stressful situations. With the help of the drug, both prevention and treatment of the above pathologies are carried out.
Postoperative ulcers of the digestive tract (both for treatment and for the prevention of ulcerative processes).
Erosive lesions of the stomach and duodenum (erosive gastritis or duodenitis, erosive esophagitis).
Ezofagoreflusksnaya stomach disease.
Functional dyspepsia, caused by increased secretion of gastric juice.
Zolinger-Ellison syndrome, or gastrinoma (a tumor in the islet of the pancreas provoking increased secretion of gastrin, which in turn has an irritant effect on the gastrointestinal mucosa, stimulating uncontrolled secretion of pepsin and hydrochloric acid).
The drug was widely used and as a preventive tool, preventing bleeding and their relapse.
Apply it also before the operations conducted under general anesthesia. It prevents the aspiration of gastric juice, i.e. Throwing acidic stomach contents into the pharynx and bronchi.
The drug "Gastrosidin" has 2 forms of release. Pharmaceutical industry produces a drug in the form of tablets of 10 pieces per blister. (the preparation package can contain 10 or 30 tablets) and lyophilate for the preparation of an injection solution.
"Gastrosidin" refers to the group of histamine H 2 - receptors. It is a drug from the third generation of the above medicines.
The main active substance is the famotidine known to many, which stands out among its similar preparations by the presence in the structure of a substituted thiazole ring, which has some antimicrobial activity.
The action of the drug is aimed at suppressing the production of hydrochloric acid in the stomach. In this case, the production of hydrochloric acid decreases both at rest (basal secretion) and when exposed to gastrin, histamine and acetylcholine, produced during meals (stimulated secretion).
Under the action of famotidine, there is also a decrease in the activity of pepsin (another stimulus for the mucosa).
The drug provides protection of the gastrointestinal mucosa from aggressive factors that support the acidic environment in the stomach, promotes the healing of erosive and ulcerative lesions of the internal part of the digestive system.
The drug helps to stop bleeding and warns them in the future. Its action stimulates mucus formation in the stomach and its production by the cells of bicarbonate, due to which regeneration of the tissues of the organ occurs.
The oral administration of tablets ensures its action within the first hour. The maximum concentration of famotidine in the blood plasma is noted after 2 hours from the administration of the drug, and the half-life is 2.5-3 hours.
Bioavailability of the drug is slightly dependent on food intake and ranges between 40-50%. Famotidine is released mainly in kidneys in its original form.
With intravenous administration of the drug solution, its effect begins after half an hour.
The antisecretory effect of the drug persists for a long time (up to 1 day).
Use of the gastrosidine during pregnancy
It is undesirable to take "Gastrosidin" during pregnancy, because the effect of famotidine on fetal development and the course of pregnancy has not been studied enough.
There is information indicating the possibility of penetration of a small amount of active ingredient in breast milk, so for the time of treatment with a child's drug, it is better to translate for artificial feeding.
In addition to the fact that the use of "gastrosidin" is not allowed for birthing and breastfeeding, there are other contraindications to the use of the drug. It is not assigned:
patients with hepatic insufficiency,
children (in the form of tablets),
with severe kidney pathologies.
Intolerance to one or more components of the drug is also an obstacle to therapy with Gastrosidine.
Special care is taken in the appointment of the drug to patients with cirrhosis of the liver, portosystemic encephalopathy, impaired renal function and urinary system.
Before prescribing a drug, it is necessary to make sure that the existing symptoms of gastric diseases are not associated with oncology (carcinoma of the stomach). Famotidine helps to reduce the intensity of the symptoms of the disease, which makes it difficult to diagnose it early and allows you to move to a more difficult stage.
Side effects of the gastrosidine
The drug "Gastrosidin" is able to influence the digestive, nervous, cardiovascular, reproductive and other systems of the human body. In this regard, there may be some undesirable symptoms.
The digestive system for taking the drug may react: nausea, vomiting, loss of appetite and taste sensations, dry mouth and pharynx mucosa, dyspepsia, constipation or diarrhea. In some cases there were signs of cholestatic jaundice, the level of liver transaminases increased.
The nervous system can respond to the administration of medication with headaches, the appearance of noise in the ears, fatigue and irritability.
From the side of the cardiovascular system, disturbances are rare in the form of arrhythmia, lowering blood pressure and heart rate.
The immune system can react to the onset of allergic reactions in the form of dry skin, the appearance of rashes and itching on them. In rare cases of drug intolerance, symptoms such as bronchospasm, Quincke's edema, anaphylaxis may appear.
Other possible symptoms: visual acuity and accommodation, changes in blood laboratory parameters, pain in muscles and joints, fever, gynecomastia, the appearance of menstrual pain, etc.
Dosing and administration
Tablets "Gastrosidin" are intended for peroral administration. They have a protective shell, which is destroyed only by the action of gastric juice. Tablets do not need to be chewed. At the time of taking the drug, they are washed down with a glass of water.
Treatment of acute conditions of erosive and ulcerative gastrointestinal lesions is carried out with the help of one-two-time administration of the drug. The drug dose of 20 mg taken 2 times a day (morning and evening) for 1 tablet. If the tablet contains 40 mg of drug substance, it is taken only in the evening before bedtime. In severe cases it is possible to increase the daily dosage to 160 mg. The course of treatment is from 4 to 8 weeks.
To combat dyspeptic phenomena with increased acidity of the stomach, the tablets are taken in a daily dosage of 20-40 mg (1 or 2 doses).
In the same dosage, the drug is prescribed to treat esophagorefluenza illness. With gastrinomide tablets with a dosage of 20 mg should be taken every 6 hours with the possibility of increasing the dose to the maximum allowable. The course of treatment for Zolinger-Ellison syndrome is from 6 to 12 weeks.
For preventive purposes, tablets are prescribed 1 time per day. The daily dose is 20 mg.
Treatment of gastroesophageal reflux in children can be done using tablets (grind and mix with water) or lyophilate. Dosage is calculated based on the weight of the patient - 1 or 2 mg per kilogram of weight per day. The received dose is divided into 2 doses, and if the child's body weight is less than 10 kg - for 3 doses.
Intravenous administration of the drug is advisable when it is not possible to take the drug inside (gastric bleeding, younger children) and during preoperative preparation. Liofizilat bred in saline.
To prevent the contents of the stomach from entering the esophagus and the respiratory tract, the drug is prescribed in the morning 2 hours before the operation in tablets (40 mg) or intravenously struino (20 mg).
With ulcerative lesions of the gastrointestinal tract and increased secretion of gastric juice, 20 mg of the drug are administered every 12 hours. The drug is administered intravenously for 2 minutes.
An overdose of the drug is observed when taking the drug in doses exceeding the permissible values. In this case, against the background of increased motor activity, there is a sharp decrease in blood pressure, nausea with bouts of vomiting, trembling of limbs, tachycardia.
After washing the stomach and taking the sorbents, symptomatic treatment is indicated.
Interactions with other drugs
It is undesirable to take Gastrosidine simultaneously with anticoagulants that increase the risk of bleeding, antacids based on magnesium hydroxides and aluminum, which reduce the absorption of famotidine, and nifedipine because of the possible short-term adverse effects on cardiac activity.
The interval between taking gastrosidin and antacids should be at least 2 hours.
Probenecid can increase the concentration of famotidine in the blood, increasing the toxic effect on the liver.
"Gastrosidin" reduces the bioavailability of cefpodoxime, worsening its solubility at high pH levels of gastric juice.
The drug is able to increase the concentration of phenytoin and cyclosporine with an increase in their toxicity with concurrent administration of drugs. But the content in the blood of intraoconazole, ketoconazole and norfloxacin under the action of famotidine decreases, which negatively affects the curative effect of these antimicrobial agents (the interval between medications should be at least 2 hours).
The development of neuropathy is associated with the simultaneous administration of gastrosidin and drugs with a depressant effect on the bone marrow.
Store the medicine at room temperature, avoiding direct sunlight and moisture.
Do not allow uncontrolled use of the drug by children and adolescents.
The drug should be withdrawn with a gradual decrease in dosage and multiplicity of intake.
"Gastrosidin" with a long course of treatment can provoke the development of gastric bacterial infections in weakened patients.
During therapy with the drug, you must limit the intake of food and drinks with irritating effect on the gastric mucosa.
Particular care during therapy with the drug should be observed in patients with impaired liver and kidney function. In this case, the doctor selects appropriate doses of the drug and monitors the condition of the sick organs.
The shelf life of any form of the drug "Gastrosidin", subject to the above requirements, is 4 years.
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Medical expert editor
Portnov Alexey Alexandrovich
Education: Kiev National Medical University. A.A. Bogomolets, Specialty - "General Medicine"
To simplify the perception of information, this instruction for use of the drug "Gastrosidine" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.
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