Garazon

Garazon is a combined anti-inflammatory and antiallergic agent used topically for ophthalmic diseases of an infectious nature.

Indications Garazon

Garazon is recommended for blepharitis, conjunctivitis and keratoconjunctivitis, keratitis, dacryocystitis, episcleritis, uveitis, iridocyclitis, retinitis, meibomite and eye injuries (including radiation, thermal and chemical burns). The drug can be used in the treatment of acute and chronic external otitis media: complicated microbial dermatitis and eczema of the external auditory canal and auricle.

[1], [2], [3], [4], [5]

Release form

Garazon - drops for eyes and ears, sterile aqueous solution (in p / e vial-droppers of 5 ml).

[6], [7]

Pharmacodynamics

Therapeutic action Garazon is provided by two active substances: the antibiotic group of aminoglycosides with gentamicin and corticosteroid betamethasone.

Gentamicin is active in infections caused by Staphylococcus aureus, Pseudomonas aeruginosa, Proteus, Klebsiella spp., Serratia spp., Neisseria spp, etc. It acts bactericidal, penetrating the cell membrane of microorganisms and violating the process of protein synthesis in them.

Synthetic fluorinated glucocorticoid (GCS) betamethasone relieves local inflammation and allergic reaction due to inhibition of the formation and release from the mast cells of mediators of the inflammatory reaction and a decrease in the movement of immunocompetent cells into the lesion focus. The antiexudative effect of betamethasone is due to narrowing of the lumen of the blood vessels and a decrease in the permeability of their walls.

[8], [9], [10], [11], [12]

Pharmacokinetics

In the official instructions to the drug, its pharmacokinetics is not represented. However, with external use of betamethasone - GCS long-term - its systemic absorption is about 14%.

[13], [14], [15], [16], [17],

Dosing and administration

For ophthalmic diseases, drops of Garazon should be injected, pulling the eyelid, into the space between the eyeball and the eyelid (subconjunctivally) - one to two drops up to four times a day. In cases of acute inflammation, the drug should be used every 2-3 hours. The standard duration of treatment is two weeks, but if the effect of treatment is not observed after 8-10 days, use of the drug should be discontinued.

In the treatment of external otitis, three drops of the drug are instilled three times a day. It is also possible to insert into the ear canal moistened with drops of turunda (with the replacement once a day).

Use Garazon during pregnancy

During pregnancy and during lactation, Garazon should not be prescribed.

Contraindications

Drops Garazon is contraindicated to use with increased sensitivity to gentaminin or betamethasou; defeat of the herpes simplex virus and varicella;

Fungal lesions of the eyes and ears; trachoma; mechanical damage or ulcers of the cornea of the eyes; active form of tuberculosis.

Garazon not apply in case of damage (perforation) of the tympanic membrane and with inflammation of the auditory nerve (neuritis).

It is contraindicated to use this drug for children under 8 years old.

Appointment of Garazon at a high degree of myopia, open-angle glaucoma, diabetes mellitus, as well as with acute suppuration, requires increased caution.

[18], [19], [20], [21], [22]

Side effects Garazon

Drops Garazon can cause side effects in the form of: rapid-itching and burning; increased intraocular pressure; impairment of vision; Opacification of the lens due to the development of subcapsular cataracts; thinning of the cornea or sclera of the eyes; pupil dilated; damage to the optic nerve; secondary infection of the focus of inflammation.

It should be borne in mind that the constituent of Garazon, gentaminicin refers to ototoxic drugs that damage the auditory nerve.

[23], [24], [25], [26], [27], [28], [29],

Overdose

In overdose Garazon, containing a synthetic steroid hormone of the adrenal glands of betamethasone, the hypothalamic-pituitary-adrenal system may be disrupted.

[30], [31], [32]

Interactions with other drugs

Information on this account in the instructions is missing.

[33], [34], [35], [36], [37], [38]

Storage conditions

Drops Garazon should be stored at a temperature of + 15-20 ° C.

[39], [40], [41]

Shelf life

3 years, after opening the bottle - no more than 1,5-2 months.

[42]