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Fiziotens
Last reviewed: 23.04.2024
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Physiotens is an antihypertensive drug. Its active component directly affects the work of imidazoline terminations of the central nervous system, which are located inside the medulla oblongata. As a result of this action, there is a weakening of the active activity of the sympathetic NA and a decrease in the indices of blood pressure.
Imidazole has a low similarity with α-adrenoreceptors, therefore, negative signs that occur quite often (strong sedation and dryness of mucous membranes) occur almost never.
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Indications Physiotens
It is used with increased values of blood pressure.
Release form
The release of the medicinal substance is sold in tablets (14 pieces inside the cell packaging). In the box - 1, 2 or 7 packs.
Pharmacodynamics
Moxondin is considered a highly effective antihypertensive agent. Existing experimental evidence demonstrates that the central nervous system is an area of moxonidine hypotensive activity. The component is a selective agonist of imidazoline endings. These endings, which are sensitive to imidazoline, are located within the rostral part of the ventrolateral region of the medulla oblongata (it is considered the center of regulation of the activity of the sympathetic PNS).
After using moxonidine, a decrease in peripheral vascular resistance occurs, which leads to a decrease in blood pressure values. The hypotensive effect of the substance was found in 2 blind blind randomized placebo controlled trials. The information obtained allows us to conclude that the use of an antagonist of angiotensin-2 in combination with moxonidine in people with increased blood pressure and left ventricular hypertrophy with the same decrease in blood pressure allowed us to more effectively potentiate the regression of left ventricular hypertrophy in comparison with the free combination of thiazide with Ca blocker.
Therapeutic testing, which lasted 2 months, showed that, compared with placebo, the drug increased insulin sensitivity index values by + 21% in people with obesity, a moderate increase in blood pressure and insulin resistance.
Pharmacokinetics
Taking into account the use of food, 60 minutes after the use of the drug, its blood indices Cmax are noted. Approximately 7% synthesized with intraplasma protein.
Inside the body, it is exchanged with the formation of guanine derivatives, as well as 4,5-dihydromoxonidine (excreted after 5 hours). In this case, moxonidine is excreted through the kidneys, for 24 hours.
Dosing and administration
It is possible to use tablets without binding to meals. During the day, it is required to use 0.2-0.6 mg of the drug (the dosage is used in 2 doses). A single dose may include no more than 0.4 mg of Physioteans.
In the case of diseases affecting the kidneys, for 1-fold use, no more than 0.2 mg of drug may be administered, and no more than 0.4 mg per day.
Use Physiotens during pregnancy
There is no information regarding the use of moxonidine in pregnant women. Testing with the participation of animals revealed an embryotoxic effect, but the probability of the risk to humans is not known. It is forbidden to prescribe Physiotes during pregnancy without extreme need.
Moxonidine is able to pass into the mother's milk, which is why it is forbidden to use it when breastfeeding. In case of emergency in the use of drugs, you need to abandon breastfeeding.
Contraindications
Among the contraindications:
- severe intolerance or allergies associated with the elements of the drug;
- bradycardia or CH;
- diseases affecting the kidneys or liver;
- SSSU.
Side effects Physiotens
The main side signs are:
- dryness affecting the mucous membranes;
- feeling weaknesses and bradycardia;
- decrease in blood pressure values;
- nausea;
- epidermal manifestations of allergy.
After the first 2 weeks of using the drug, the frequency and severity of negative symptoms decreases.
Storage conditions
Physiotens is kept in a place protected from sunlight, at standard temperature.
Shelf life
Physiotens can be used within a 2-year term from the time the drug was manufactured.
Application for children
You can not appoint in pediatrics (children under 18 years of age).
Analogs
Analogues of the drug are Moxogam, Estapik with Tenaxum and Clophelin.
Reviews
Physiotes receives positive reviews. Regular prolonged use of drugs leads to an effective decrease in blood pressure. Of the negative aspects, side effects are noted (usually it is dryness of the oral mucous membranes and headaches), but they gradually disappear after the first weeks of use.
In the comments on the medical forums emphasize the fact that the medication should not be stopped abruptly, and you should also avoid skipping portions.
Attention!
To simplify the perception of information, this instruction for use of the drug "Fiziotens" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.