Fix

Fix is an antibacterial drug that is applied systemically. The drug belongs to the group of cephalosporins of the 3rd generation.

The principle of therapeutic effect of drugs is developed by the pronounced suppression of the processes of binding the walls of bacterial cells. The drug has a strong bactericidal activity. At the same time, it demonstrates resistance against the activity of β-lactamases, which are produced by a large number of bacteria (gram-negative as well as positive).

Indications Fixa

It is used in case of development of pathologies with an infectious-inflammatory nature, triggered by the action of microbes sensitive to cefixime:

• lesions of the upper region of the respiratory tract (among those, sinusitis with pharyngitis and otitis media with tonsillitis);
• infections of the lower zone of the respiratory ducts (bronchitis in the active or chronic phase, pleurisy, and atypical or bacterial pneumonia);
• lesions of bones, subcutaneous tissues and epidermis (impetigo, erysipelas, folliculitis, infectious wounds and furunculosis);
• biliary tract disorders (cholecystitis or cholangitis);
• infection of the urogenital tract (pyelonephritis, prostatitis with cystitis, gonorrhea or endometritis);
• typhoid fever or intestinal infections.

It is also used for scarlet fever or cystic fibrosis.

[1], [2], [3]

Release form

The release of drugs produced in capsules - 4 or 10 pieces inside the pack.

Pharmacodynamics

The drug has a high degree of efficiency in relation to the and Citrobacter amalonaticus) and -positive microbes (streptococci).

Resistance to drugs is shown by listeria monocytogenes, staphylococci, pseudomonads, clostridia with enterococci of subgroup D, bacteroids fraglis and enterobacteria.

[4], [5], [6], [7], [8], [9],

Pharmacokinetics

When using drugs, absorption occurs inside the gastrointestinal tract. The level of bioavailability is approximately 50%. Serum indicators of Cmax are noted after 3-4 hours from the moment of use. The term half-life of a drug depends on the size of the dosage and is approximately 3-4 hours.

About 50% of the dosage is excreted with the urine in an unchanged state, and another 30% is excreted by the intestine along with the bile.

[10], [11],

Dosing and administration

Adolescents over the age of 12 (weight over 50 kg) and adults should take an average of 0.4 g of the substance 1 times a day (or 0.2 g 2 times a day). Per day is allowed to consume no more than 0.4 g of drugs. The therapeutic cycle lasts 1-2 weeks on average.

The portion size in people with GFR indicators in the range <50 /> 10 ml per minute equals 0.3 g per day in 2 uses with a 12-hour interval (first take 0.2 g of the drug, and after 12 ti hours - another 0.1 g).

Persons with a GFR level <10 ml per minute should be applied at 0.2 g per day in 2 uses with a 12-hour break (at 0.1 g).

Capsules are swallowed without chewing, with a simple water.

[16], [17], [18], [19]

Use Fixa during pregnancy

Pregnant fixes are prescribed only if there are strict indications, when the likely benefit to the woman is more expected than the risks of consequences for the fetus.

It is forbidden to use the medicine when breastfeeding. It is necessary to refuse breastfeeding for the period of drug intake.

Contraindications

It is contraindicated to prescribe medication to people with intolerance against penicillins and cephalosporins.

[12], [13], [14]

Side effects Fixa

Main adverse events:

• symptoms associated with the work of the liver and gastrointestinal tract: nausea, dry oral mucous membranes, pain affecting epigastrium, anorexia, diarrhea, vomiting, and in addition jaundice with cholestasis, transient increase in liver transaminase activity, dysbiosis, hyperbilirubinemia and candidiasis affecting the gastrointestinal tract. Occasionally, the introduction of a drug causes stomatitis, colitis of a pseudomembranous nature or glossitis;
• allergy symptoms: urticaria, epidermal rash, skin hyperemia;
• disorders associated with the work of the central nervous system: dizziness or headaches;
• disorders of hematopoietic processes: leuko-, thrombocyto-or neutropenia, as well as anemia of hemolytic nature and eosinophilia;
• lesions of the urinary system: tubulointerstitial nephritis.

[15]

Overdose

In case of poisoning, vomiting, diarrhea or nausea are noted.

It should immediately perform gastric lavage. In addition, symptomatic events are held.

[20],

Storage conditions

Fix must be kept in a locked from the children, dry and dark place. Temperature values - maximum 25 ° С.

[21], [22], [23]

Shelf life

Fix is allowed to apply for a 24-month term since the sale of the drug.

[24], [25]

Application for children

Children of the age group of 1-12 years old take Fix as a suspension. The portion is calculated in the ratio of 8 mg / kg per day (used for 1 or 2 uses).

[26], [27]

Analogs

Analogues of drugs are Lopraks, Supraks Solyutab, Vinex, Maxibat with Cefigo, and in addition Ikzym, Cefik, Sorcef with Flamyfix and Cefixime. Also on the list is the Suprax Comfort, Cefix and Fixim with Ceforal Solyub.

[28]