Ferrovir

Ferrovir stimulates the activity of antiviral, antimicrobial, and also fungicidal immunity.

[1], [2]

Indications Ferrovira

It is used to treat the following pathologies:

• hepatitis type C ;
• herpes virus infection (1st or 2nd type) of origin (for any form of localization);
• generalized form of herpesvirus infection in people from the immunocompetent category;
• tick-borne encephalitis ;
• uterine cervical dysplasia caused by HPV (as part of etiopathogenetic treatment);
• HPV infection (warts, as well as dysplasia or condyloma);
• herpes in the genital area, having a chronic or regularly recurring nature;
• CMVI;
• use in people with HIV / AIDS.

Release form

The release of the medication is realized in the form of a solution of 15 mg / ml, in glass bottles containing 2 or 5 ml. Inside a special blister-pallet is placed 10 bottles of 2 ml or 5 bottles of 5 ml. Inside the box there is 1 such blister-pallet.

Pharmacodynamics

It has a powerful antiviral effect against RNA or DNA-containing viruses.

The active element, having a natural nature, has a pronounced immunomodulatory effect.

For people with HIV / AIDS, a 14-day treatment cycle can increase CD4 + lymphocyte counts. The impact of the drug lasts 30-45 days. Additionally, there is a weakening of the viral load inside the body, as a result of which the HIV RNA index decreases in dynamics with initial values.

The 10-day treatment cycle helps to reduce the duration of the recurrence of a herpesvirus infection, and also provides a longer remission with a regularly recurring nature of the disease.

Combined treatment in people with chronic hepatitis type C helps to reduce the replication of the HCV virus (for all existing genotypes), and also puts the disease into a latent stage with further recovery of hepatocellular cells, as well as slowing viral replication.

Ferrovir demonstrates activity against major viruses, as well as opportunistic pathologies.

There is also information about the positive effect of therapy in conditions and diseases caused by HPV and EBV.

Pharmacokinetics

The absorption of the substance with the further distribution inside the organs with tissues with intramuscular injections is carried out at a rather high speed. Distributional processes take place through the endolymphatic transport system. Ferrovir has a powerful tropism for the blood-forming organs.

The drug is embedded inside the cell structures, participating in cellular metabolic processes. Daily coursework causes the accumulation of active elements inside the organs with tissues.

Values Cmax of the active drug element are marked after half an hour; then there is a gradual decrease in this indicator - the substance begins to be distributed inside the body. Half-life is 36 hours. Multiple injections (every day for 4 days) lead to the cumulation of the drug inside the spleen, bone marrow, and lymphatic system.

After the introduction of the 5th injection, there is no increase in the indices of the active elements inside the tissues with organs.

Metabolic products are excreted mainly with the urine, and another part - with feces. Inside the body, the medicine is retained for about 72 hours (on average).

[3]

Dosing and administration

The drug should be administered exclusively in the / m way (at low speed, for 1-2 minutes).

The use of the drug for herpes virus infection: enter through the / m injection, 2 times a day for 10 days, 5 ml of the substance. Also during the clinical tests another effective treatment regimen was determined: 75 mg (with a 24-hour interval) was administered once a day; cycle time is also 10 days.

With CMVI or herpes in the genital area (chronic or recurrent), 2 ml of the drug is used 2 times a day; The cycle lasts 10-15 days.

Combination therapy for co-infection of viral origin in the genital area (HPV + herpes): intramuscular injection of 5 ml of the substance 1-fold per day. The interval between procedures is 24 hours, and the treatment cycle lasts 10 days.

Therapy for HPV: the introduction of 5 ml of drugs with 48-hour intervals. The treatment cycle is 10 days.

Treatment of uterine cervical dysplasia caused by HPV is performed according to the following scheme: use of 5 ml of the drug with a 48-hour interval. The whole cycle consists of 10 injections.

People with CMVI need 2 times a day to inject 5 ml of the drug in the i / m way. The cycle time is 10 days.

For the treatment of tick-borne encephalitis, it is necessary to inject intramuscularly 15 mg / ml of the substance (2 times per day) for 10-15 days.

In case of AIDS or HIV: 5 ml of medication is administered 2 times a day; course therapy lasts 14 days. Repeat the cycle if necessary, after 1-1.5 months.

In case of category C hepatitis: administer 5 ml of the drug 2 times a day; The course lasts 14 days. At the end of this cycle, it is necessary for the next 2 weeks to introduce the drug in a day in the same daily portion.

[6]

Use Ferrovira during pregnancy

It is forbidden to appoint Ferrovir when breastfeeding or pregnancy.

Contraindications

It is contraindicated to appoint in the presence of individual intolerance in relation to medications.

[4]

Side effects Ferrovira

Ferrovir is often tolerated without the development of complications. Occasionally, in the injection area there is a slight skin hyperemia and pain. The temperature of the patient may also rise for a short time - up to 38 ° C.

[5]

Interactions with other drugs

Ferrovir can enhance the drug activity of anticoagulants.

The drug reduces the severity of negative manifestations, as well as reduces the toxicity of antiviral and antimicrobial drugs, as well as antimycotics and cytostatics used in the combined treatment.

This effect can be explained by the optimization of metabolic processes within the hepatocyte liver cells, as well as the cytoprotective activity of the drug.

[7], [8], [9]

Storage conditions

Ferrovir must be kept at a temperature parameter within 4-20 marks ^of C. Open vials must be used immediately, store them forbidden.

Shelf life

Ferrovir can be stored within 5 years from the moment of production of the drug (if the bottles are not opened).

Application for children

The drug is not used in pediatrics.

Analogs

Analogues of the medication are drugs Herpes Simplex, Flavozid and Proteflazid with Immunostat.

Reviews

Ferrovir gets quite a variety of reviews. Some patients write that a course of treatment using drugs has led to a prolonged remission of the virus, significantly enhancing immunity, as well as resistance to other diseases. But there are those who doubt the effectiveness of the drug, because it is impossible to remove the virus from the body.

Both physicians and patients leave positive comments on the treatment of HPV - the drug effectively inhibits HPV activity.

Of the minuses emit a high price of medication, because of which not everyone can buy it. In addition, due to the lack of data confirming the safety of drugs when used in pediatrics, it can not be used in children - this is often in their reviews on the forums noted by the parents.