Favier

Favir is a medicinal product with the international and chemical name Efavirenz. Let's consider the features of this drug, indications for use, dosage, side effects and interaction with other medications.

Favir is a hard, opaque gelatin capsule. Each capsule of the favir contains a crystalline powder of yellowish color. The active substance of the drug is efavirenz. One capsule of the favir contains 200mg of efavirenz.

Also in the composition of the drug include and auxiliary substances, such as: lactose, corn starch, hard gelatinous shell, sodium lauryl sulfate, talc, silicon colloidal dioxide, methylparaben and propylparaben. Pharmacotherapeutic group Favir - antiviral drugs.

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Indications Favier

Indications for use Favir is HIV infection. If, when taking a favir, the patient has mild symptoms of hypersensitivity to the active substance efavirenz, then the drug is replaced with antihistamines.

The drug is part of the comprehensive treatment of HIV infection. Favir has an effective effect on the body, but has many contraindications in use. The active substance efavirenz can disturb the concentration of attention. Therefore, when taking the drug is recommended to abandon the management of vehicles and work with mechanisms and automatic equipment.

[2], [3], [4], [5]

Release form

The form of the release is a gelatin capsule. The advantage of this form of release is obvious, since when the capsule enters the interior, the gelatinous layer dissolves quickly, and the substance spreads through the body. Due to this, the drug has an antiviral effect much faster than drugs whose dosage form is tablets.

Pharmacodynamics

Pharmacodynamics Favir allows you to learn about the biochemical effects that the drug has on the human body and viral infections. Favier is a non-nucleoside selective inhibitor. The drug inhibits the activity of the enzymes of the virus and prevents the transcription of viral RNA along the complementary DNA strand. Thanks to this, the drug protects the body from a viral infection and prevents it from taking on a chronic form.

Pharmacodynamics Favir controls the processes of distribution of the main active substance throughout the body and its effect on viral infections, and infectious diseases.

[6], [7], [8], [9], [10], [11]

Pharmacokinetics

Pharmacokinetics Favir is based on the processes that occur with the drug in the body. And this is the process of drug absorption, metabolism and the period of excretion of the active substance. Favir has a moderate absorption in the gastrointestinal tract. The drug is recommended not to be taken with food, as fatty food reduces the bioavailability of the drug.

The maximum concentration of the drug in the blood is observed four hours after admission. The drug completely binds to proteins in the blood plasma. In this case, the drug penetrates poorly through the blood-brain barrier. Favir is metabolized in the liver and is excreted with feces or urine. The half-life of the drug is from 45 to 75 hours.

[12], [13], [14], [15], [16], [17]

Dosing and administration

The method of administration and dose of the drug is prescribed by the doctor when drawing up a treatment regimen for the patient's disease. As a rule, the favir is prescribed in combination with other drugs. For adults, the recommended dose of favir is 600 mg per day. For children and adolescents, the dose of the drug depends on weight and age.

The recommended dose for children is 600 mg per day and weights over 40 kg. The drug is not allowed while eating. If during the reception of the drug there are side effects or symptoms of an overdose, then the drug is taken only at night.

[24], [25], [26], [27], [28], [29]

Use Favier during pregnancy

Use Favir during pregnancy is not recommended. But according to studies, the drug does not affect the development of the baby. In addition, Favir reduces the risk of transplacental transmission of the virus. Favir is not allowed to take during breastfeeding, as the drug penetrates into breast milk, which means it enters the baby's body.

The drug is prescribed for children who are over three years old and have a body weight of more than 13 kilograms. The drug has the same therapeutic effect as in adult patients. But children experience side effects of the drug more often. Typically, it is a skin rash, itching and gastrointestinal disorders.

Contraindications

Contraindications to the use of Favir are based on the individual intolerance of the drug and the substances that make up its composition. Let's consider a number of absolute contra-indications to reception of a preparation favir.

• Pregnancy
• Lactation period
• Hypersensitivity to the components of the drug Favir
• Renal insufficiency
• Diseases of the liver
• Viral hepatitis
• Addiction
• Age of the patient less than three years old
• Alcoholism
• Body weight less than 13 kg
• Encephalopathy.

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Side effects Favier

As a rule, side effects of Favir occur when the drug is overdosed or hypersensitivity to the components. So, with the application of the favir, you may experience itching, burning, a rash on the skin. In rare cases, patients develop Stevens-Johnson syndrome. The main side effects of favir are:

• Dizziness, insomnia, fatigue, reduced concentration of attention, neuralgia, neuropathy.
• Problems with the urinary system, the formation of concrements in the kidneys, hematuria.
• Nausea, vomiting, diarrhea.
• Problems with the liver and pancreas, pancreatitis, hepatitis, increased activity of transmnase.
• Hyperglycemia, suffocation.

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Overdose

Overdosing of the drug increases side effects. The nervous system lends itself to a particular effect in an overdose; in some cases, the patient may experience involuntary muscle twitching.

In case of an overdose, allergic reactions to the skin are observed in patients. To remove the symptoms of an overdose, it is recommended to stop using favir and seek medical help. To accelerate the withdrawal process, it is recommended to take activated charcoal. There is no specific antidote for drug excretion.

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Interactions with other drugs

The interaction of Favir with other drugs is allowed, since Favir is included in the complex antiviral treatment. The drug interacts well with such drugs as saquinavir, amprenavir, indinavir.

At simultaneous reception of a favir with clarithromycin, the level of the last decreases on 30% in a blood. This significantly increases the risk of side effects, allergic skin reactions and rashes. When selecting drugs for complex treatment, the doctor selects such drugs to minimize side effects for the patient.

[31], [32], [33], [34], [35], [36], [37]

Storage conditions

Storage conditions Favir provide a special temperature regime, up to 25 degrees Celsius, protection from sunlight and storage of the drug in a place inaccessible to children.

If the rules for storage of the drug are not observed, the medicine loses its physico-chemical properties, which significantly affects the treatment process. In addition, with improper storage of the favir, the patient may experience a number of side effects of the drug.

[38], [39], [40], [41]

Shelf life

Shelf life is two years from the date of manufacture of the drug, which is indicated on the package. After the expiration date, the drug must be disposed of. The drug is not allowed to be used after the expiration date, as unforeseen side effects and reactions of the organism are possible.

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