Fastum Gel

Fastum gel is used for lesions of the waist-sacral plexus, phlebitis and thrombophlebitis, and so on.

[1]

Indications Fastum Gel

Fastum gel is used for lesions of the sacroiliac plexus, phlebitis and thrombophlebitis, nonspecific lymphadenitis, lymphangitis, rheumatoid arthritis, unspecified, gout, arthrosis, ankylosing spondylitis, dorsalgia, sciatica, lumbago with sciatica, synovitis and tendosynovitis, other bursopathies, bursopathies, unspecified, unspecified , rheumatism, unspecified, myalgia, osteochondropathy, unspecified, traumas of unspecified parts of the trunk, extremities or areas of the body, dislocations, sprains and injuries of capsules flax and ligaments of the joints unadjusted part of the body.

[2], [3]

Release form

It is available as a colorless gel, which is almost transparent. Has a pleasant smell and a low-fat to the consistency. Fastum gel is packaged in aluminum tubes of thirty or fifty grams of the drug in each. Each tube is placed in a cardboard box and is supplied with a leaflet with the instruction. A hundred grammes of the gel contains two and a half grams of active substance - ketoprofen, as well as auxiliary components - purified water, ethyl alcohol, lavender essential oil, Neroli essential oil, carbomer 940, diethanolamine.

[4]

Pharmacodynamics

Fastum gel has analgesic, anti-inflammatory and anti-exsudative effects. The action of the drug is based on inhibiting the production of prostaglandins. Ketoprofen is able to penetrate through the skin to the focus of inflammation, which provides the opportunity for local therapy of various problems with joints, ligaments, tendons and muscles, which are accompanied by pain.

[5], [6]

Pharmacokinetics

Fastum gel is able to penetrate the inflammatory focus through the skin. Ketoprofen is absorbed into the blood from the above source at a very slow rate. The percentage of bioavailability of the active substance is no more than five percent. If the used dose of the drug is from fifty to one hundred and fifty milligrams, then the amount of substance in the serum in five to eight hours will be from 0.08 to 0.15 μg per ml. The substance does not have the ability to accumulate in the body. The half-life period lasts from one to three hours. Ketoprofen binds to serum proteins from sixty to ninety percent. The active substance in the course of metabolism is converted into glucuronide, which is excreted from the body by the kidneys.

[7]

Dosing and administration

Fastum gel is used externally. In this case, a strip of the drug length of five to ten centimeters is applied a thin layer on the desired area of the skin with light rubbing movements. This procedure should be repeated up to two times a day. It is possible to use medicinal product and physiotherapy (phonophoresis and iontophoresis) simultaneously. The course of treatment with a medication is up to ten days.

[12], [13]

Use Fastum Gel during pregnancy

Fastum gel is forbidden to use during pregnancy and lactation period.

Contraindications

• The patient's age is up to twelve years.
• The presence of an individual hypersensitivity to the active substance or auxiliary components of the drug.
• The presence of hypersensitivity to acetylsalicylic acid, fenofibrate or other non-steroidal anti-inflammatory drugs.
• The bronchospasm, hives, and rhinitis in the patient's medical history, which are caused by the use of acetylsalicylic acid.
• The presence of photosensitization in a patient's anamnesis.
• The possibility of skin allergy to substances such as ketoprofen, tiaprofenic acid, fenofibrate, as well as perfumes and products that protect against sunlight.
• The presence of wet dermatoses, eczema, infected abrasions and wounds in those places where it is necessary to apply the gel.
• Reception of sunbathing, as well as the use of a solarium during gel treatment, and also within two weeks after the end of its application.

[8], [9], [10]

Side effects Fastum Gel

• Skin covers - the emergence of erythema, itching and eczema. Sometimes there are cases of the appearance of photosensitivity, bullous dermatitis, urticaria. Seldom there may be symptoms of contact dermatitis and angioedema.
• Digestive system - in rare cases, there may be signs of peptic ulcers, bleeding and diarrhea.
• The immune system - in rare cases, there are symptoms of anaphylactic reactions, as well as hypersensitivity.
• The urinary system - in very rare cases, the drug contributes to the aggravation of the course of renal failure.

[11],

Overdose

Fastum gel has a very low systemic absorption of its active substances, which virtually eliminates overdose with external use of the drug. If a large amount of the drug is ingested, it may cause systemic side effects. In this case, symptomatic therapy is indicated.

Interactions with other drugs

Ketoprofen enhances the effectiveness of medications that promote photosensitivity. Data on other interactions are absent. Although patients who use anticoagulants, related to the coumarin series, should regularly monitor the international normalized attitude.

[14], [15]

Storage conditions

Fastum gel should be kept out of reach of children at a temperature not exceeding 30 ° C.

[16]

Shelf life

Fastum gel is suitable for 5 years from the date of release.

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