Fastum gel

Fastum gel is used for lesions of the lumbosacral plexus, phlebitis and thrombophlebitis, etc.

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Indications Fastum gel

Fastum gel is used for lesions of the lumbosacral plexus, phlebitis and thrombophlebitis, nonspecific lymphadenitis, lymphangitis, unspecified rheumatoid arthritis, gout, arthrosis, ankylosing spondylitis, dorsalgia, sciatica, lumbago with sciatica, synovitis and tendosynovitis, other bursopathies, unspecified bursopathies, unspecified enthesopathies, unspecified rheumatism, myalgia, unspecified osteochondropathies, injuries to unspecified parts of the trunk, limbs or body regions, dislocations, sprains and injuries to the capsular-ligamentous apparatus of joints of an unspecified part of the body.

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Release form

It is produced in the form of a colorless gel, which is almost transparent. It has a pleasant smell and a non-greasy consistency. Fastum gel is packaged in aluminum tubes of thirty or fifty grams of the drug in each. Each tube is placed in a cardboard package and supplied with a leaflet with instructions. One hundred grams of gel contains two and a half grams of the active substance - ketoprofen, as well as auxiliary components - purified water, ethyl alcohol, lavender essential oil, Neroli essential oil, carbomer 940, diethanolamine.

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Pharmacodynamics

Fastum gel has analgesic, anti-inflammatory and anti-exudative effects. The action of the drug is based on inhibition of prostaglandin production. Ketoprofen is able to penetrate through the skin to the site of inflammation, which provides the possibility of local therapy of various problems with joints, ligaments, tendons and muscles, which are accompanied by pain.

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Pharmacokinetics

Fastum gel is able to penetrate into the inflammatory focus through the skin. Ketoprofen is absorbed into the blood from the above-mentioned focus at a very slow rate. The percentage of bioavailability of the active substance is no more than five percent. If the dose of the drug used was from fifty to one hundred and fifty milligrams, then the amount of the substance in the blood serum after five to eight hours will be from 0.08 to 0.15 mcg per ml. The substance does not have the ability to accumulate in the body. The half-life is from one to three hours. Ketoprofen binds to serum proteins from sixty to ninety percent. The active substance during metabolism is converted into glucuronide, which is excreted from the body by the kidneys.

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Dosing and administration

Fastum gel is used externally. In this case, a strip of the drug five to ten centimeters long is applied in a thin layer to the desired area of the skin with light rubbing movements. This procedure should be repeated up to two times a day. It is possible to use the drug and physiotherapy (phonophoresis and iontophoresis) simultaneously. The course of treatment with the drug is up to ten days.

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Use Fastum gel during pregnancy

Fastum gel is prohibited for use during pregnancy and lactation.

Contraindications

• The patient's age is under twelve years.
• The presence of individual hypersensitivity to the active substance or auxiliary components of the drug.
• Presence of hypersensitivity to acetylsalicylic acid, fenofibrate or other non-steroidal anti-inflammatory drugs.
• The patient has a history of bronchospasms, urticaria, and rhinitis that are caused by the use of acetylsalicylic acid.
• The patient has a history of photosensitivity.
• Possibility of skin allergy to substances such as ketoprofen, tiaprofenic acid, fenofibrate, as well as to perfumes and sunscreens.
• The presence of weeping dermatoses, eczema, infected abrasions and wounds in the areas where the gel needs to be applied.
• Sunbathing and use of a solarium during treatment with the gel, as well as for two weeks after its use.

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Side effects Fastum gel

• Skin – erythema, itching and eczema. Sometimes there are cases of photosensitivity, bullous dermatitis, urticaria. Rarely, symptoms of contact dermatitis and angioedema may occur.
• Digestive system - in rare cases, signs of peptic ulcer, bleeding and diarrhea may be observed.
• Immune system – in rare cases, symptoms of anaphylactic reactions and hypersensitivity appear.
• Urinary system - in very rare cases, the drug contributes to the aggravation of renal failure.

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Overdose

Fastum gel has a very low systemic absorption of its active substances, which virtually eliminates overdose when using the medication externally. If a large amount of the drug gets inside, it may cause systemic side effects. In this case, symptomatic therapy is indicated.

Interactions with other drugs

Ketoprofen increases the effectiveness of drugs that promote photosensitivity. There are no data on other interactions. Although patients who use anticoagulants related to the coumarin series should regularly monitor the international normalized ratio.

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Storage conditions

Fastum gel – keep out of reach of children, at a temperature not exceeding 30C°.

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Shelf life

Fastum gel is valid for 5 years from the date of manufacture.

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