F-gel

F-gel is an effective anti-inflammatory, analgesic agent with antiplatelet effect. Let's consider the features of this medication, the way it acts and the therapeutic effect on the body.

F-gel contains in its composition the active substance - ketoprofen. The composition of the medicament includes substances such as: lavender oil, nipagin, carbomer, trometamol. The drug has antimradikinin activity and is responsible for the stabilization of lysosomal membranes. That is, it releases enzymes that contribute to the destruction of tissues in chronic inflammatory diseases.

The medication is absorbed into the skin very slowly and does not accumulate in the body. According to the research, bioavailability of the drug is 5%. The dose of f-gel in 50-150 mg, in 5-7 hours after application forms in a blood plasma of 0,15 mkg / ml of substance.

F-gel is a medicinal preparation that is used to treat muscle pain, injuries, sprains and bruises. The drug has an excellent anti-inflammatory effect and relieves pain from the affected area. The drug is dispensed without a prescription, but before applying f-gel it is recommended to consult a doctor.

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Indications F-gel

The main indications for use are pain in the muscular system. The drug is recommended for use with:

• Sports injuries that provoked muscle pain, joint pain.
• Dislocations, bruises, ruptures of tendons and ligaments, sprains.
• Excessive physical exertion that negatively affects the joints.
• Pain in the lower back.
• Degenerative rheumatic diseases.

Medication is recommended to use after consultation with a therapist, surgeon or dermatologist. Before use, it is necessary to check the body for the action of the medicine. It is enough to put a little f-gel on the elbow and check after a couple of hours. If the skin has redness or a rash, then you are allergic to this medication, so it is better to abandon it.

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Release form

The form of production - aluminum tube 30 grams. The active substance in the gel tube is 2.5%. The advantage of this form of release is noticeable, since the gel is convenient to store and use. The tube has a convenient lid, which reliably protects the drug from drying out and outflow.

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Pharmacodynamics

Pharmacodynamics allows you to learn about the active substances that are part of the drug. The main active substance of the f-gel is ketoprofen. One gram of f-gel contains 25 mg of ketoprofen. The composition of the f-gel includes a number of other active substances, such as carbomer 980, purified water, trometamol, tromethamine and others.

The therapeutic effect of the drug is achieved through the rapid penetration of the active substance to the source of the lesion. Despite the fact that the cream is slowly absorbed, it perfectly enriches the body with substances that act as analgesics. 

[8], [9], [10], [11], [12], [13], [14],

Pharmacokinetics

Pharmacokinetics allows you to learn about the processes that occur in the body with medication. This is the process of absorption, distribution, metabolism and excretion of the drug. The effectiveness of these processes depends on the effectiveness of treatment of f-gel.

F-gel is used for muscle and joint pain, after applying the medication to the skin, the active substance penetrates into the lower layers of the skin and acts on the lesion. The process of metabolism of f-gel does not take longer than 2 hours, while the f-gel does not accumulate in the body. At the end of this time, the drug is withdrawn. For effective treatment it is recommended to apply the medication several times a day.

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Dosing and administration

The way of application and the dose of the drug depend on the disease, that is, the pain that is to be treated. The drug is recommended for adults and children who are older than 15 years. F-gel is applied to the skin with a small strip of 5 centimeters or more, depending on the size of the lesion. The gel is spread thinly over the skin until completely absorbed. The drug is recommended to apply 2-3 times a day. On average, continued treatment with f-gel should not exceed ten days. To improve the effectiveness of the drug is recommended to use occlusive dressings.

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Use F-gel during pregnancy

Use during pregnancy is contraindicated. Also, it is necessary to refrain from using the medication during lactation. It is especially dangerous to use the medication in the first and second trimester of pregnancy. Since the medicine has a potential negative effect on the baby's future.

F-gel during pregnancy is used only if the therapeutic effect for the mother is much more important than the healthy development of the unborn child.

Contraindications

The main contraindications for use are the individual intolerance of the medication or the active substances that make up its composition. Also, there are a number of other contraindications.

• Attacks of bronchial asthma
• Rhinitis
• Gastrointestinal bleeding in anamnesis
• Stomach ulcer
• Diseases of the duodenum
• Pain in abdominal stomach
• Renal insufficiency
• Pregnancy
• Lactation
• Skin dermatitis
• Damage to the skin (rash, eczema, infection)
• The patient's age is up to 15 years.

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Side effects F-gel

Side effects may occur due to misuse of the drug or in case of an overdose. With prolonged use of f-gel on the skin, an allergic reaction may occur. As a rule, it is a small puffiness, hyperemia, urticaria or itching, in rare cases, patients experience photosensitization. More rarely, there are side effects such as asthma attacks, anaphylactic reactions or Stevens-Johnson syndrome. If the drug is used by patients with renal insufficiency, then there may be an exacerbation of kidney diseases and even interstitial nephritis.

There are a number of caveats that will protect against side effects. The drug is only allowed to be applied externally, while avoiding contact with the eyes, open wound areas and mucous membranes. If the use of the drug causes burning and redness on the skin, then the use of f-gel should be discarded.

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Overdose

Overdose can be caused by individual sensitivity or intolerance of active substances. Systemic symptoms of overdose may occur due to prolonged use of the drug. Overdose manifests itself more often as skin dermatitis. Overdosing can also occur due to high doses and frequent use of f-gel.

During an overdose, there are side effects such as: nausea, severe headache, dizziness, unpleasant and painful sensations in the epigastric region. The drug affects the reaction rate when controlling the mechanisms and the car. F-gel is strictly prohibited for use by patients who are under 15 years of age.

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Interactions with other drugs

Interactions with other drugs are allowed, but are undesirable. The preparation shows a slight absorption of the active substance ketoprofen. If methotrexate is used when using f-gel, the latter drug shows increased toxicity.

With the interaction of f-gel and diuretics, the effect of the latter is significantly reduced. Simultaneous reception of f-gel, diuretics, angiotensinconvertase and inhibitors increases the risk of renal dysfunction and the cardiovascular system. If the drug is used together with oral anticoagulants, then the patient should be under medical supervision, since there is a high risk of bleeding. F-gel is strictly prohibited for use with non-steroidal anti-inflammatory drugs.

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Storage conditions

The storage conditions of the F-gel must meet the requirements for the storage of any ointments and medicinal gels. The F-gel should be stored in a dark, cool place, subject to a temperature range of 15 ° C to 25 ° C.

If the storage rules are not observed, the drug loses its medicinal properties and changes its physico-chemical properties. F-gel is recommended to store in the original packaging, as this will ensure its better safety.

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Shelf life

Shelf life is 24 months, that is two years from the date of production, which is indicated on the package of the drug. The shelf life of the drug depends largely on the storage conditions. So, with proper storage, the drug retains its initial characteristics. F-gel has a specific smell and is a gel colorless, almost transparent structure.

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