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Eucazoline
Last reviewed: 03.07.2025

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Evkazolin is classified as a medicine used to treat colds accompanied by a runny nose. The medicine can be produced in the form of a spray or nasal drops.
Manufactured by JSC Farmak, Ukraine, Kyiv.
Evkazolin is available without a prescription; prior consultation with a specialist is advisable.
Indications Eucazoline
The external use medication Evkazolin is prescribed:
- to facilitate breathing through the nose in cases of rhinitis, rhinosinusitis, hay fever, accompanied by significant swelling of the mucous membranes of the nasal cavity and hypersecretion;
- to reduce swelling of the nasopharyngeal tissues in cases of otitis media;
- as preparatory procedures for diagnostics and therapy of the nasal cavity.
Release form
Evkazolin can be produced in the form of a spray, in a glass bottle with a special dispenser (10 g), or in the form of drops, in a glass bottle with a nozzle for drop dosing (10 g). Each bottle is packed in an individual cardboard package.
The active component of the drug is xylometazoline hydrochloride in the amount of 1 mg. Additional substances include: benzalkonium chloride, eucalyptus oil, propylene glycol, macrogol, povidone, etc.
Pharmacodynamics
Evkazolin is a medicine for a runny nose for external use. The active substance xylometazoline is able to reduce the filling of the lumen of blood vessels, relieve swelling of mucous tissues. The medicine has a pronounced vasoconstrictor effect, reduces the degree of redness of tissue surfaces and the release of exudate, which helps restore normal nasal breathing.
Eucazolin effectively reduces the manifestations of the inflammatory process and inhibits the growth of microbial cells. Eucalyptus oil acts as a soft antispasmodic and moisturizer for the mucous membrane, in addition, eucalyptus is able to suppress the development of Staphylococcus aureus, Mycobacterium tuberculosis, the causative agent of dysentery and Trichomonas. Eucalyptus essential oils also have a distracting and analgesic effect.
Pharmacokinetics
The medication cannot have any systemic effect on the body, since when applied locally, the absorption of active components into the blood is extremely insignificant.
When used externally, the therapeutic effect is observed within the first minutes, with a total duration of action of up to 10 hours.
Dosing and administration
The drug is used externally:
- Evkazolin spray - allows the active substance to be evenly distributed over the surface of the tissues of the nasal cavity. Can be prescribed to adults and children from 12 years of age. The spray is injected once into each nostril, the injection can be repeated after 8-10 hours;
- Evkazolin in the form of drops - used from 7 to 12 years of age - one drop in each nostril, with possible re-administration after 8-10 hours. Adults administer up to 2 drops in each nostril, the interval between the administration of drops is 8-10 hours. Duration of treatment is up to one week.
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Use Eucazoline during pregnancy
Since the medication does not penetrate into the systemic bloodstream, its use in standard dosages during pregnancy is allowed. Local use of the medication is also allowed during breastfeeding. There is no need to stop breastfeeding during treatment with the drug.
Contraindications
Contraindications to the use of Evkazolin are:
- hypersensitivity of the body to the components of the drug;
- increased intraocular pressure;
- atrophy of the mucous tissues of the nasal cavity;
- hypertension;
- hyperthyroidism (thyrotoxicosis).
The drug in the form of a spray is used for children from 12 years of age.
The drop form of Evkazolin can be used from 7 years of age.
Side effects Eucazoline
The drug has minimal side effects, which are quite rare. Among them:
- a feeling of tingling and dryness in the nasal cavity;
- sneezing urge;
- liquefaction and hypersecretion of exudate;
- temporary deterioration of olfactory functions;
- signs of atrophy of the mucous membranes;
- cardiac disorders;
- increased blood pressure;
- allergic manifestations.
Long-term and unsystematic use of the drug can lead to decreased susceptibility to its properties.
Overdose
Significant excess of recommended dosages may provoke the development of visual dysfunctions, hypertension, increased intraocular pressure, migraine, drying of the nasopharyngeal mucosa. Long-term use of high doses of the drug may lead to the development of atrophy of the mucous tissues at the injection site.
Treatment of overdose is carried out by prescribing sympatholytic drugs and α-adrenoblockers (for example, phentolamine). If necessary, symptomatic therapy is prescribed.
In case of accidental ingestion of the drug, gastric lavage, intake of sorbent medications (activated carbon, sorbex) and, sometimes, laxatives (regulax, bisacodyl) are used.
Interactions with other drugs
The drug Evkazolin can interact with other medications only if the drug has a resorptive effect.
Adrenoreceptor stimulating agents (ephedrine, galazolin, naphthyzin, mezaton) can enhance the effects of Evkazolin.
Beta-adrenergic receptor blockers (adrenaline, noradrenaline), sympatholytic agents (octadine, reserpine) and calcium channel blockers (cinnarizine, verapamil, amlodipine) can weaken the effect of Evkazolin.
Tricyclic antidepressants (imipramine, azafen) reduce their own activity when used simultaneously with Eucasoline.
The effect of combined use of Evkazolin with monoamine oxidase inhibitors (metralindol, selegiline) may be reduced.
Sympathomimetics should not be administered concomitantly with sedatives.
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Storage conditions
It is recommended to store the preparation in its original packaging at a temperature of 22-24°C, avoiding exposure to direct ultraviolet rays.
Shelf life
Shelf life: up to 2 years.
Attention!
To simplify the perception of information, this instruction for use of the drug "Eucazoline" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.