Enterospasmyl

Enterospasmil is a complex drug that belongs to a group of substances that affect the digestive function and the work of the gastrointestinal tract; it is used to treat digestive activity.

The medication contains phloroglucinol dihydrate (a non-atropine type antispasmodic) and simethicone. The drug prevents the accumulation of gases in the intestines, eliminates stomach spasms (also with bloating) and reduces the rate of peristalsis. [ 1 ]

Indications Enterospasmyl

Used in combination therapy for digestive disorders. Used for smooth muscle spasms, which can also be accompanied by pain of varying severity and bloating of various origins:

• flatulence associated with dyspepsia, gastrointestinal dysfunction and aerophagia;
• Botkin's syndrome, postoperative period, pyloro- or cardiospasm and gastritis;
• colitis, cholecystitis, enteritis, cholangitis, diarrhea, IBS, papillitis, cholecystolithiasis and pericholecystitis.

It is also prescribed for lesions of the urinary tract and gynecological diseases, against the background of which smooth muscle spasms and flatulence are observed. It can be used during preparation for ultrasound and X-ray procedures.

Release form

The therapeutic product is released in the form of capsules, 15 or 30 pieces per box.

Pharmacodynamics

Simethicone is an organosilicon substance, which is part of the polydimethylsiloxane group. It has an antifoaming effect. Simethicone has no toxic properties, it affects the surface tension of gas bubbles formed inside the gastrointestinal tract, destroying them. The gases released in this case are naturally released with the intestinal contents through its peristalsis. Some of these gases are also absorbed into the walls of the small intestine.

In gastritis, simethicone demonstrates an analgesic effect. It helps to stabilize gastric function, improving well-being and digestion processes. [ 2 ]

Clinical testing has confirmed a relaxing effect on the smooth muscles of the gastrointestinal tract. Phloroglucinol dihydrate reduces the rate of excessive motility of the large intestine and colon, which typically occurs as a reaction to eating in people with intestinal disorders. [ 3 ]

Pharmacokinetics

When taken orally, phloroglucinol is absorbed at a high rate and participates in metabolic processes during the first intrahepatic passage. Excretion occurs in the form of metabolic elements, mainly with urine. The period of reaching plasma Cmax is 60 minutes. With a Cmax of 2.74 mg / ml, the half-life is 2 hours. The overall level of bioavailability when taken orally is 30%.

Simethicone is not absorbed into the body and is excreted unchanged after passing through the gastrointestinal tract.

Dosing and administration

The medication is taken with or after food when pain occurs.

For children aged 6-12 years, the serving size is 1 capsule, taken 3 times a day. For adolescents aged 12 years and older and adults, take 2 capsules of the drug 3 times a day.

In case of preparation for diagnostic procedures, you need to take 1 capsule the day before the procedure, 2 times a day, and then in the morning on the day of the examination, another 1 capsule.

No more than 6 capsules are allowed per day. The recommended dose cannot be exceeded during treatment. The duration of therapy is determined by the attending physician.

If negative symptoms develop that are not noted in the instructions, as well as if there is no result after using Enterospasmil for 2 days, you should consult a doctor.

• Application for children

The medication should not be prescribed to children under 6 years of age.

Use Enterospasmyl during pregnancy

Enterospasmil should not be prescribed to pregnant or breastfeeding women.

Contraindications

It is contraindicated for use in case of severe intolerance to the active components of the drug or its auxiliary elements, and is also not prescribed in case of obstruction in the gastrointestinal tract or intestinal obstruction.

Side effects Enterospasmyl

In case of severe sensitivity, side effects may develop, which are expressed by the following symptoms: dyspeptic disorders (vomiting, xerostomia, nausea) and signs of allergy (itching, rashes, allergic urticaria).

Overdose

In case of poisoning, symptomatic procedures should be performed. The medication is discontinued, gastric lavage is performed, and the use of sorbents is prescribed.

Interactions with other drugs

It is necessary to avoid combining fluoroglucinol with powerful analgesics, including morphine or its derivatives, since this can provoke the development of a spasmodic effect.

Storage conditions

Enterospasmil should be stored at temperatures no higher than 25°C.

Shelf life

Enterospasmil can be used for a period of 24 months from the date of manufacture of the therapeutic product.

Analogues

Analogues of the drug are Spascuprel, Iberogast and Gastritol with fragrant dill fruits, and in addition to this Gastrokind and Enterokind. The list also includes Caraway fruits, Hilak and Fennel fruits.