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Endothelon
Last reviewed: 04.07.2025
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Endotelon is an angioprotector and has venotonic medicinal activity.
The main element of the medicine is oligomers obtained from a water-soluble extract contained in grape seeds. They have a protective effect on collagen with elastin and structural proteins, preventing their denaturation with splitting.
The medicine has a plant base and has a therapeutic effect aimed at increasing venous tone and strengthening the strength of capillaries and blood vessels.
Indications Endotelona
It is used to eliminate lymphatic edema that appears after therapy for breast carcinoma (to remove the subjective feeling of tension in the epidermis in this area).
It can be used in cases of venous-lymphatic insufficiency: discomfort when in a horizontal position, paresthesias that feel like “goosebumps”, as well as a feeling of heaviness with pain in the legs.
Prescribed in case of disturbance of microcirculation processes in the area of the retina and vascular membranes – to prevent the development of complications.
Release form
The drug is produced in tablets - 10 pieces in a plate, in a pack - 2 such plates.
Pharmacokinetics
Procyanidol oligomers, which are derivatives of flavans, are absorbed at high speed through the gastrointestinal tract. These components are synthesized mainly with tissues containing a large number of aminoglycans (including perivascular connective).
Plasma Cmax values are recorded after 1.5 hours; the half-life is 72 hours.
Approximately 70% of the drug with its metabolic components is excreted in the feces; approximately 20% is excreted in the urine, and approximately 5% is excreted through the respiratory system.
Dosing and administration
Endotelon must be taken orally.
For phlebological and lymphological disorders, the drug is taken in the morning and evening in a dose of 0.15 g. The therapy cycle lasts 20 days.
For the treatment of ophthalmological pathologies, take 0.1-0.15 g of the medication per day.
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Use Endotelona during pregnancy
Although animal experiments have not revealed any teratogenic effects of Endotelon, and no embryotoxic effects have been observed in clinical practice, the available information is insufficient to completely exclude the risk in case of use during pregnancy. For this reason, it is used during this period only under strict indications and with the doctor's prescription.
Since there is no information on whether the drug is excreted in breast milk, it should not be administered during lactation.
Contraindications
Main contraindications:
- severe intolerance to procyanidol oligomers or other components of the medication;
- fructose malabsorption or glucose-galactose malabsorption;
- deficiency of sucrase-isomaltase (due to the presence of sucrose in the drug).
Storage conditions
Endotelon must be stored in a place inaccessible to small children. Temperature values are a maximum of 25°C.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Endothelon" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.