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Elivel
Last reviewed: 23.04.2024
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Elivel is part of a group of antidepressant medications.
[1]
Indications of the elivela
It is used in such cases:
- psychosis of manic-depressive type (in its depressive phase);
- depression (also child), as well as behavioral disorders and emotional disorders of a mixed type;
- various phobias;
- anorexia of the psychogenic type;
- To control digestive behavior of abnormal nature in the development of bulimia.
Release form
Release in tablets, 10 pieces inside a blister pack. The pack contains 10 such blisters.
Pharmacodynamics
Elivel - a medicine that belongs to the category of tricycles. It has antiserotonin, antihistamine and anticholinergic properties. The mechanism of its impact is due to the slowing down of the processes of reuptake by neurons of elements such as serotonin and dopamine with norepinephrine.
The drug helps to improve mood during the depressions of a variety of etiologies, but it works most effectively with depressions of the endogenous type. The tamolitic effect of drugs is combined with a strong sedative effect, so it has a particularly powerful effect in conditions of depression and anxiety, against which sleep disorder and arousal are observed.
Pharmacokinetics
After consuming the pill, the substance is quickly absorbed inside the digestive tract. The synthesis of the drug with plasma protein is 94%.
The half-life of the substance is approximately 20 hours. Metabolism occurs inside the liver, as a result of which an active primary product of decomposition, nortriptyline, is formed. Components of amitriptyline with nortriptyline pass through the BBB and penetrate into the mother's milk.
Excretion of the substance is carried out mainly in the form of decomposition products - together with urine.
Dosing and administration
The size of the initial dosage of drugs is 50-75 mg per day (this dose is taken for several doses). If there is such a need, it is allowed to increase the dosage within 5-6 days (gradually), to 150 mg per day (outpatient) and 200 mg per day (inpatient). Most of the drug should be taken before bedtime.
After obtaining a stable drug exposure, the dosage is reduced to 50-100 mg per day, and then for at least 3 more months the procedures of maintenance treatment continue. The drug effect begins to appear after 7-10 days of therapy.
If there are no improvements in the patient's condition after 3 weeks of treatment, the medicine should be withdrawn. In this case, the cancellation should be carried out gradually - the dosage is reduced in the period of 2 weeks.
The duration of the treatment course should not be more than 6-8 months.
[3]
Use of the elivela during pregnancy
Use Elivel during pregnancy is allowed only in situations where the benefits for women exceed the risk of the appearance of the fetus negative symptoms.
If you need to take the medicine during lactation, you must refuse for this period from breastfeeding.
Contraindications
The main contraindications:
- intolerance of the components of the drug;
- the presence of glaucoma;
- intestinal obstruction of paralytic type;
- seizures of epilepsy;
- pyloric stenosis;
- myocardial infarction in acute phase;
- combination with MAOI medicines.
Side effects of the elivela
Taking tablets can cause these side effects:
- mental reactions and manifestations from the NA: sensation of confusion, agitation, disorientation or drowsiness, development of ataxia, dizziness, dysarthria, insomnia, headaches, polyneuropathy. Also there are hallucinations and convulsions, and in addition numbness of the extremities and changes in EEG indices. The process of the release of ADH and the ability to concentrate attention can be disrupted;
- violations of the CAS function: the development of tachycardia, myocardial infarction, postural hypotension and stroke, increased blood pressure, as well as heart rhythm or cardiac conduction disorder;
- reactions due to anticholinergic properties of drugs: disorder of accommodation, development of mydriasis, visual fuzziness, increase in IOP level. There is also a delay in urination and dilatation of the urinary tract. There may appear constipation, dryness of the oral mucosa, hyperrexia and intestinal obstruction of the paralytic type;
- disorders in the digestive tract: the development of stomatitis or anorexia, the appearance of vomiting, diarrhea or nausea, and in addition discomfort in epigastrium and a disorder of taste buds;
- others: the development of alopecia, galactorrhea or gynecomastia, the appearance of a rash on the skin, weakening of the potency and libido, weight gain / decrease, swelling in the parotid glands and disorders of the hematopoiesis. There is a functional liver failure.
[2]
Overdose
Due to drug intoxication, such manifestations occur: bradycardia, arrhythmia, lowering of blood pressure, AV-conduction disorder, and hepatic function. The development of side effects in severe form is also a symptom of an overdose. Often, to reduce them, it is sufficient to reduce the dosage or temporarily discontinue the drug.
The method of treatment is gastric lavage and saline laxatives with activated charcoal. There is no antidote to Elivel. Symptomatic treatment may also be performed. It is required to keep the victim under regular supervision (monitoring of ECG and BP parameters). To eliminate bradycardia, it is permitted to use β1-adrenomimetics or atropine, and also to temporarily set the pacemaker.
Interactions with other drugs
The suppressive effect of Elivel on the central nervous system is potentiated when combined with such drugs: anticonvulsants, opiates, central anesthetics, sleeping pills, neuroleptics, anesthetic drugs and alcoholic beverages.
The combination of holinoliticheskih means and Elivela increases the probability of the appearance of intestinal obstruction of the paralytic type.
Combined use with cimetidine may increase the plasma values of Elivel.
The drug is able to block the hypotensive effect of guanitidine.
Storage conditions
Elivel should be kept in a place that is closed from penetration of moisture and sunlight, and also inaccessible to children. The temperature is not more than 25 ° C.
[6]
Shelf life
Elivel is allowed to use in the period of 4 years since the release of the drug.
Attention!
To simplify the perception of information, this instruction for use of the drug "Elivel" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.