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Ecomed

Ecomed is an antibiotic with a large range of drug activity.

Indications of the ecomed

It is used in the treatment of such infectious pathologies provoked by bacteria-pathogens that are sensitive to the active substance of drugs:

  • ENT organs together with the upper part of the respiratory system: sinusitis with angina, and in addition, otitis media with tonsillitis, as well as scarlet fever;
  • the lower part of the respiratory system: pneumonia of bacterial or atypical form (pulmonary inflammation), as well as bronchitis (bronchial inflammation);
  • subcutaneous tissue and skin: impetigo and erysipelas, and in addition to this dermatosis secondary type of infection;
  • pathology in the area of the urogenital system: gonorrhea or non-gonorrheal urethritis or cervicitis (inflammation in the uterine neck region);
  • Tick-borne borreliosis (infectious pathology, provoked by spirocheta of Borrelia).

Release form

Release in capsules. Ecomed with a volume of 500 mg - 3 capsules inside the blister. In a separate package - 1 blister plate.

Ecomed 1000 is produced by 4 capsules inside the blister. In a pack - 1 blister plate with capsules.

Ecomed 250 is available in 6 capsules inside the blister plate. In a separate pack - 1 blister with capsules.

Pharmacodynamics

Macrolide antibiotic, which is a subgroup of azalides. In the case of creating a high level of concentration within the inflammatory focus, the drug acquires bactericidal properties.

Among the bacteria sensitive to the component:

  • Gram-positive cocci: streptococcus pyogenes, pneumococcus, streptococcus agalactia, staphylococcus aureus, streptococci of types C and F with G, and St. Viridans;
  • gram-negative microbes: moraxella cataralis, legionella pneumophilus, hemophilic rod, Ducrea's stick, Campylobacter vellum, pertussis tick and paraculation, and also gardnerella vaginalis and gonococcal;
  • individual anaerobes: clostridium perfringence, Bacteroides bivius and peptostreptococci;
  • and in addition: Mycoplasma pneumonia, Borrelia Burgdorfer, Chlamydia trachomatis, pale treponema and ureaplasma urealitikum.

The drug does not show activity against Gram-positive microorganisms resistant to erythromycin.

Pharmacokinetics

Absorption of azithromycin from the gastrointestinal tract is rapid, this process is due to the fact that the substance has lipophilicity and resistance to an acidic medium. With the use of 500 mg of LS, the peak plasma index is observed after 2.5-2.96 hours and equal to 0.4 mg / l. The level of bioavailability is 37%.

The substance is well distributed inside the tissues and organs of the genitourinary system (this includes the prostate), respiratory organs, subcutaneous layer and skin. The level of concentration inside the tissues is higher than inside the plasma (10-50 times), which is due to (together with a long half-life) the weak synthesis of azithromycin with a plasma protein, and in addition the ability of the component to pass into the eukaryotic cells and accumulate in a medium with a low index The pH that surrounds the lysosomes. Such properties contribute to high indicators of the distribution volume (31.1 l / kg) and clearance within the plasma.

The ability of the active substance to accumulate mainly within the lysosomes is very important for the processes of elimination of bacterial pathogens within cells. It was revealed that the phagocytes move the medicine to the site of inflammation, where it is released by phagocytosis. The level of concentration of the component inside the infectious foci is higher than inside the healthy tissues (mean - 24-34%) and correlates with the severity of puffiness. Although azithromycin is found in large numbers inside phagocytes, it does not have a significant effect on their activity.

Bactericidal indices of the substance remain inside the inflammatory foci in the period of 5-7 days after the use of the last dosage. This allows the use of short-term therapeutic courses (for 3 or 5 days).

Excretion of the component from the plasma is carried out in 2 stages: the half-life is 14-20 hours (in the interval 8-24 hours after the capsule is consumed) and the 41st hour (in the interval 24-72 hours) for which the reception of drugs can occur once per day.

Use of the ecomed during pregnancy

Ecomed is not given to pregnant or lactating women. Exceptions are cases where the benefit of using it is higher than the risk of complications.

Contraindications

The main contraindication is the intolerance of any macrolides.

Caution is required when using drugs in people with functional renal / hepatic disorders at a severe level, and in addition, if there is a history of the patient's history of allergy manifestations.

Side effects of the ecomed

Taking capsules can cause these side effects: diarrhea, nausea, and abdominal pain. More rarely there is swelling and vomiting. There may be a temporary increase in the activity of liver enzymes. Single appear rashes on the skin.

Dosing and administration

Before using the drug it is required to find out the sensitivity of the pathogenic microflora relative to it.

The medication should be taken once a day - before meals (1 hour) or after it (after 2 hours).

Dosage Ecomed for adults:

  • with diseases in the upper and lower parts of the respiratory system, as well as in the subcutaneous layer with the skin: 0.5 g of the drug on the first day, and then in the 4-day period, take 0.25 g (or 0.5 g every day for a period of 3 days). The total dose per course is 1.5 g;
  • acute pathology in the area of urogenital organs: a one-time intake of the 1st g of medicine;
  • in the treatment of tick-borne borreliosis (early stage): the first dose is given for the first day, and then the daily use of 0.5 g of medication for the next 4 days. The total dose per course is 3 g.

The sizes of children's doses are determined depending on the weight. For children weighing more than 10 kg: for the first day - 10 mg / kg, and for the next 4 days - 5 mg / kg. The treatment course can last for 3 days - with a single dose for taking every day will be 10 mg / kg. The course requires taking 30 mg / kg of the drug.

Overdose

Due to the development of an overdose, the following symptoms usually occur in patients: transient loss of hearing, diarrhea, and also vomiting and severe nausea.

To treat violations it is necessary to rinse the stomach and take aluminum - or magnesium-containing antacids.

Interactions with other drugs

Ekomed potentiates the effects of dihydroergotamine, as well as ergot alkaloids.

When combined with chloramphenicol and tetracyclines, the properties of drugs are increased, and in combination with lincomycin - on the contrary, decrease.

Ethyl alcohol, antacid drugs and food reduce the degree of absorption of the drug and its speed.

The drug increases the serum index, inhibits excretion and potentiates the toxic properties of the following drugs: anticoagulants of indirect action, felodipine with cycloserine and methylprednisolone.

Slowing down the oxidative processes of microsomes inside the hepatocytes, the drug inhibits excretion, prolongs the half-life, and in addition increases the toxic effect and increases the concentration of such drugs: valproic acid with carbamazepine, phenytoin and ergot alkaloids with disopyramide and hexobarbital, and besides this bromocriptine with oral antidiabetics and Theophylline with other derivatives of xanthines.

It is not compatible with heparin.

Storage conditions

Ecomedes should be stored in a place protected from moisture and sunlight, and also inaccessible to children. Temperature values range from 15-25 ° C.

Shelf life

Ecomed can be used in the period of 2 years from the date of release of the medicinal product.

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Medical expert editor

Portnov Alexey Alexandrovich

Education: Kiev National Medical University. A.A. Bogomolets, Specialty - "General Medicine"

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Attention!

To simplify the perception of information, this instruction for use of the drug "Ecomed" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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