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Health

Benzonal

, medical expert
Last reviewed: 03.07.2025
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Benzonal is an anticonvulsant drug. It belongs to the category of barbiturates and their derivatives.

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Indications Benzonala

It is used to treat various types of epilepsy.

Helps to eliminate seizures of polymorphic or non-convulsive epilepsy (it is used in combination with other anticonvulsants - diphenin, as well as carbamazepine and hexamidine).

In addition, it is an integral component of the combined treatment of hemolytic pathology in newborns.

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Release form

Available in tablets of 0.05 or 0.1 g. Each blister contains 30 tablets of 0.05 g. The package contains 1 blister plate. Tablets of 0.1 g are available in 50 pieces inside a blister plate. The pack contains 1 such blister.

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Pharmacodynamics

The drug has anticonvulsant properties. It acts as an enzyme inducer and also increases the activity of the liver monooxygenase enzyme system. The hypnotic effect is almost absent.

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Pharmacokinetics

Benzonal undergoes rapid metabolism in the body, during which the substance phenobarbital is released, which has an anticonvulsant effect. It is weakly synthesized with plasma protein.

The substance is distributed in equal quantities within different tissues and organs. It passes through hematoparenchymatous barriers and penetrates into mother's milk. The process of component release is quite slow. Metabolism occurs with the help of microsomal enzymes. It has the ability to accumulate within the body. The half-life is 3-4 days.

Excretion is carried out by the kidneys; the substance is excreted both unchanged and in the form of decay products.

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Dosing and administration

Benzonal is taken orally after meals. The course of therapy begins with a minimum single dose, with a gradual (every 2-3 days) increase until the required daily medicinal dose is reached. If stable compensation is observed, it is necessary to gradually reduce the dose until a single daily dose is obtained. If attacks return, it is necessary to restore the optimal daily dose.

The doctor prescribes the dosage sizes, taking into account the patient's health condition: the adult single dosage is 0.1-0.2 g, and the daily dosage is 0.8 g. The maximum adult dosages are: single - 0.3 g, daily - no more than 1 g. The therapeutic course lasts a long time and is continuous.

The daily dose for newborns is 5.9 mg/kg. The drug should be prescribed to infants with caution. For children under 3 years of age, the required number of tablets should be ground into powder, then dissolved in water and used as a suspension.

Children's dosage:

  • single dose for 3-6 years old – 0.025-0.05 g (0.1-0.15 g of medicine must be taken per day);
  • for 7-10 years old – 0.05-0.1 g (within 0.15-0.3 g of the drug per day);
  • for 11-14 years old – 0.1 g (about 0.3-0.4 g of LS per day).

Maximum doses for children (at an older age): single dose – 0.15 g, daily dose – 0.45 g.

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Use Benzonala during pregnancy

The medicine should not be prescribed during pregnancy (1st and 3rd trimester), as well as during lactation.

Contraindications

Among the contraindications:

  • the presence of hypersensitivity to the components of the drug;
  • diabetes mellitus;
  • severe parenchymal liver diseases;
  • renal pathologies in which their functional disorder is observed;
  • decompensation in cardiac function;
  • state of depression.

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Side effects Benzonala

The use of the drug may cause the following side effects: tolerance to Benzonal, drug dependence, a feeling of drowsiness and lethargy, headaches, problems with speech or gait, hearing loss and allergic reactions.

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Overdose

Manifestations of overdose include the development of nystagmus or ataxia, or speech disorder.

To eliminate the disorders, you should reduce the dosage of the drug or take caffeine (at a dosage of 0.05-0.075 g per dose).

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Interactions with other drugs

Benzobital potentiates the properties of anesthetics, painkillers, neuroleptics with hypnotics, alcoholic beverages, as well as tranquilizers and drugs for general anesthesia.

The drug also weakens the effect of anticoagulants with griseofulvin, tetracyclines, quinidine and paracetamol, as well as xanthines with glucocorticoids and calciferol with cardiac glycosides.

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Storage conditions

Benzonal should be stored in a place where it is not exposed to sunlight and moisture, and inaccessible to children. Temperature indicators are within 15-25°C.

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Shelf life

Benzonale can be used for a period of 4 years from the date of release of the drug.

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Attention!

To simplify the perception of information, this instruction for use of the drug "Benzonal" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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