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Diseases of the genitourinary system

Tubulo-interstitial nephropathies

To tubulointerstitialnoe nephropathies include a variety of diseases of the kidneys that occur with the primary lesion of mainly tubular structures and interstitium.

Bartter's Syndrome

Bartter's syndrome is a genetically determined tubular dysfunction manifested by hypokalemia, metabolic alkalosis, hyperuricemia and increased activity of renin and aldosterone.

Renal tubular acidosis

Renal tubular acidosis - metabolic, GFR, as a rule, is not changed. Proximal renal tubular acidosis is formed with a decrease in the ability of epithelial cells to reabsorb bicarbonates. Observed isolated or in the framework of Fanconi syndrome (primary and secondary) proximal renal tubular acidosis.

Aminoaciduria and cystinuria

Aminoaciduria (amino acid) is an increase in the excretion of amino acids in the urine or the presence of amino acids in the urine that are not normally contained in it (for example, ketone bodies).

Glycosuria

Glucosuria - an increase in the excretion of glucose in the urine. Renal glucosuria is often an independent disease; it is usually discovered by chance; polyuria and polydipsia are extremely rare. Sometimes renal glucosuria is accompanied by other tubulopathies, including as part of Fanconi syndrome.

Tubular dysfunction

Nephropathy, characterized mainly by a violation of transport processes, as a rule, with a preserved filtration function of the kidneys, tubular dysfunction.

Amyloidosis and Kidney Damage: Treatment

In addition to the main therapeutic regimens, the treatment of amyloidosis should include symptomatic methods aimed at reducing the severity of congestive circulatory insufficiency, arrhythmias, edematous syndrome, correction of arterial hypotension or hypertension.

Amyloidosis and Kidney Damage: Diagnosis

In secondary AA-amyloidosis, 80% of patients consult a doctor during the onset of nephrotic syndrome of varying severity.

Amyloidosis and kidney damage: causes and pathogenesis

The basis of tissue deposits of amyloid is amyloid fibrils - special protein structures with a diameter of 5-10 nm and a length of up to 800 nm, consisting of 2 or more parallel filaments.

Amyloidosis and kidney damage

Amyloidosis is a group concept combining diseases that are characterized by extracellular deposition of a specific insoluble fibrillar protein amyloid.

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