Tubular dysfunction
Last reviewed: 23.04.2024
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Nephropathy, characterized mainly by a violation of transport processes, as a rule, with a preserved filtration function of the kidneys, tubular dysfunction.
Causes of the tubular dysfunction
Most of the tubular dysfunction is primary, genetically determined; symptoms of tubular dysfunction develop usually already in childhood. Genetically determined tubular dysfunction is caused by mutations that cause changes in the structure of membrane carrier proteins, functional insufficiency of membrane proteins, and changes in the sensitivity of tubular epithelium cells to the action of hormones.
However, in some diseases, secondary tubular dysfunction is observed.
Forms
Classification of tubular dysfunction
- Glucosuria.
- Aminoaciduria :
- aminoaciduria with excretion of cystine or dibasic amino acids;
- aminoaciduria with excretion of neutral amino acids;
- iminoglycinuria and glycinuria;
- aminoaciduria with excretion of dicarboxylic amino acids.
- Disorders of reabsorption of phosphates.
- Renal tubular acidosis:
- proximal;
- distal.
- Fanconi syndrome.
- Kidney diabetes insipidus.
- Tubular dysfunction with hypokalemia.
Tubular dysfunction is subdivided by localization - the primary involvement of the proximal or distal tubule.
In the designation of tubular dysfunction, usually a substance and / or an ion whose transport is impaired (isolated glucosuria, cystinuria) is called.
[8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20]
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