Canalicular dysfunction

Nephropathy, characterized mainly by a violation of transport processes, as a rule, with preserved filtration function of the kidneys, tubular dysfunctions.

Causes tubular dysfunction

Most tubular dysfunctions are primary, genetically determined; symptoms of tubular dysfunctions usually develop in childhood. Genetically determined tubular dysfunctions are caused by mutations that cause changes in the structure of membrane carrier proteins, functional insufficiency of membrane proteins, and changes in the sensitivity of tubular epithelial cells to the action of hormones.

However, in some diseases, secondary tubular dysfunctions are observed.

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Forms

Classification of tubular dysfunctions

• Glucosuria.
• Aminoaciduria:
  • aminoaciduria with excretion of cystine or dibasic amino acids;
  • aminoaciduria with excretion of neutral amino acids;
  • iminoglycinuria and glycinuria;
  • aminoaciduria with excretion of dicarboxylic amino acids.
• Impaired phosphate reabsorption.
• Renal tubular acidosis:
  • proximal;
  • distal.
• Fanconi syndrome.
• Renal diabetes insipidus.
• Tubular dysfunction with hypokalemia.

Tubular dysfunctions are divided by localization - predominant involvement of the proximal or distal tubule.

When referring to tubular dysfunction, the substance and/or ion whose transport is impaired is usually named (isolated glucosuria, cystinuria).

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