Diseases of the blood (hematology)

Diseases of the spleen

Primary diseases of the spleen are extremely rare, and even then mostly degenerative processes and cysts. But as a symptom splenomegaly occurs quite often and is a manifestation of many diseases.

Modern methods of diagnosis and treatment of paroxysmal nocturnal hemoglobinuria

Paroxysmal nocturnal hemoglobinuria (APG) is a rare (orphanic) disease. Mortality in paroxysmal nocturnal hemoglobinuria is about 35% within 5 years of the onset of the disease.

Correction of blood loss in surgery

The blood loss in surgery is an inevitable aspect of surgical intervention. At the same time, it is important to not only localize the surgical intervention, but also the volume, diagnosis, the presence of concomitant pathology, the initial state of the blood indicators.

Primary hemochromatosis: causes, symptoms, diagnosis, treatment

Primary hemochromatosis is a congenital disease, characterized by a marked accumulation of iron, causing tissue damage. The disease is not clinically manifested until the development of organ damage, often irreversible. Symptoms of the disease include weakness, hepatomegaly, bronze skin pigmentation, loss of libido, arthralgia, manifestation of cirrhosis, diabetes, cardiomyopathy.

Diseases of iron overload: causes, symptoms, diagnosis, treatment

When iron (Fe) enters in amounts exceeding the body's requirements, it is deposited in tissues as hemosiderin. The deposition of iron leads to tissue damage (with a total iron content in the body> 5 g) and is called hemochromatosis. Local or generalized deposition of iron without tissue damage is called hemosiderosis.

Multiple myeloma

Multiple myeloma (myelomatosis; plasma cell myeloma) is a plasma cell tumor that produces a monoclonal immunoglobulin that implants and destroys nearby bones.

Monoclonal gammopathy of undetermined nature

With monoclonal gammopathy of an indeterminate nature, M-protein is produced by non-malignant plasma cells in the absence of other manifestations of multiple myeloma. The incidence of monoclonal gammapathy of uncertain character (MGNH) increases with age, from 1% in people aged 25 to 4% in people older than 70 years.

Macroglobulinemia

Macroglobulinemia (primary macroglobulinemia, Waldenstrom's macroglobulinemia) is a malignant plasma-cell disease in which B cells produce large amounts of monoclonal IgM. Manifestations of the disease include increased blood viscosity, bleeding, recurrent infections and generalized adenopathy.

Diseases of heavy chains: causes, symptoms, diagnosis, treatment

Diseases of heavy chains are neoplastic plasma-cell diseases characterized by hyperproduction of heavy chains of monoclonal immunoglobulin. Symptoms, diagnosis and treatment vary according to the specificity of the disease.

Plasma cell diseases: causes, symptoms, diagnosis, treatment

Plasma cell diseases (dysproteinemia, monoclonal gammopathies, paraproteinemia, plasma cell discourses) are a group of diseases of unknown etiology characterized by a disproportional proliferation of one B cell clone, the presence of structurally and electrophoretically homogeneous (monoclinic) immunoglobulins or polypeptides in blood serum or urine.

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