Diprospan in psoriasis: treatment and reviews

Diprospan in psoriasis is considered a highly effective remedy, since it belongs to the category of GCS. This is a hormonal drug with a prolonged effect. Multilateral influence of the drug on metabolic processes helps the body to adapt to the stressful effects of the environment.

[1], [2], [3],

Indications of the diprospan in psoriasis

Among the indications for the use of the drug - generalized psoriasis, and in addition psoriatic arthritis and psoriatic erythroderma in severe forms.

[4], [5], [6], [7]

Release form

It is produced in ampoules with an injection solution (1 ml volume). The package contains 1 or 5 ampoules.

Injections of Diprospan in psoriasis

During the procedure, you must follow certain rules:

• Injections are performed only if there are indications;
• They need to be done only in the hospital, since after the injection there may be complications in the form of a sharp decrease in blood pressure or anaphylaxis. Timely assistance in this case will be available only in the polyclinic or in inpatient treatment;
• The dosage of injections must be observed very carefully.

Pharmacodynamics

Diprospan is a glucocorticoid with immunosuppressive, anti-allergic, anti-shock, anti-inflammatory and hyposensitizing properties. In addition, the drug has a mineralocorticoid effect, but the effect is poorly expressed and when administered therapeutic dosages has no clinical significance. The active component of betamethasone disodium phosphate accelerates the onset of the therapeutic effect of the drug.

[8], [9]

Pharmacokinetics

In addition to betamethasone phosphate, the disodium preparation also contains betamethasone dipropionate. The first of them is able to be absorbed quickly, and also easily hydrolyzed, resulting in a therapeutic effect almost immediately. The elimination time is 24 hours. The second component is first cumulative in the body, and then begins a gradual release. The duration of this process is 10 days, which determines the prolonged effect of this drug.

[10], [11]

Dosing and administration

To eliminate the disease, patients are given injections of medication at a dosage of 1 ampoule IM. The interval between the procedures should last 14 days. The treatment course includes 3 procedures for the introduction of Diprospan.

[14]

Use of the diprospan in psoriasis during pregnancy

Although the teratogenic effect of Diprospans has not been sufficiently studied, many gynecologists speak negatively about it. Most doctors speak out against its use in pregnant women. Diprospan, and other SCS, is able to pass through the placenta, and in addition to penetrate into the mother's milk.

If the drugs were prescribed even before the pregnancy, after determining the condition, you should begin to gradually reduce the dosage of the drug.

Contraindications

Diprospan is contraindicated in such cases:

• at a diabetes, a tuberculosis, a stomach ulcer;
• hypertension in severe form, mental illness;
• hypercortisy syndrome and glaucoma;
• infections that are viral in nature;
• thromboembolic dysgenitalism, and in addition to these fungal diseases;
• Werlhof's disease, as well as purulent infections.

[12]

Side effects of the diprospan in psoriasis

With a short course of use of Diprospan, the risk of developing strong side effects is very small, but in the case of prolonged use, they may occur. There may be such reactions:

• Disorders of the central nervous system: a feeling of depression or excitement, a heightened sense of anxiety, neuroses;
• Gastrointestinal organs: disorders in the digestive system, as well as polyphagia;
• Metabolic disorders: osteoporosis, weight increases dramatically, patients with diabetes are deteriorating health status, the course of infectious pathology is complicated, children are delayed in growth, and cortico-adrenal suppression develops.

[13]

Overdose

Overdosage with diprospan in the treatment of psoriasis can cause such manifestations:

• vomiting with nausea;
• problems with sleep;
• excited or euphoric state.

[15]

Interactions with other drugs

In combination with NSAIDs, the risk of ulcers and bleeding in the digestive tract increases.

Diprospan reduces the effect of diuretics, insulin, vaccines, anticoagulants, as well as oral medications. The properties of the drug are enhanced in combination with hormonal contraceptives.

[16], [17]

Storage conditions

Keep the medicine required in a place closed from light and inaccessible to children in a temperature of 2-25 ° C. Freeze the drug can not.

[18], [19], [20]

Shelf life

Use of the medicine is allowed within 3 years from the date of manufacture.

[21]

How to replace Diprospan in psoriasis?

There are a lot of different medicines for psoriasis. Depending on which active component is contained in these drugs, they can be divided into several groups:

• immunosuppressants (such as styla, as well as humir and remicade);
• immunomodulators (such as thymalin and pyrogenal, as well as glutoxim);
• hepatoprotectors (for example, heptor, as well as heptral);
• antihistamines (for example, tavegil or chloropyramine);
• GCS (this hydrocortisone, flosteron, and in addition metipred and prednisolone).

What's better? Diprospan or Kenalog for psoriasis

Both Kenalog and Diprospan are glucocorticosteroids, so their properties converge. The results of the tests revealed that Diprospan is more effective than Kenalog, but it should be borne in mind that it costs a little more.

Reviews about Diprospan for psoriasis

Diprospan in psoriasis is prescribed very carefully, since it has many serious side effects. Therefore, the drug is not allowed to be used alone.

Reviews of people treated for psoriasis by Diprospan are rather ambiguous. Many people note the positive effects of the drug, but along with this, there are many complaints that the disease subsequently worsens. In some patients, as a result of treatment with this drug, the disease was transformed into a hormone-dependent form.

Testimonies indicate that the medicine leads to remission of the disease, but after each new injection, its duration is reduced, and the relapse of psoriasis takes on a more pronounced form.