Diffusive liver changes


Diffuse liver changes do not mean a certain disease, but only indicate an increase in the liver parenchyma (the main tissue of the organ).

Changes in the parenchyma may be swelling, hypertrophic, sclerotic, dystrophic, but in any case, an additional examination is required to establish an accurate diagnosis.


A similar condition occurs with liver dysfunction and is detected at any age.

Causes of the diffuse changes in the liver

Diffuse liver changes are due to alcohol abuse, smoking, unhealthy diet, genetic abnormalities, the use of potent drugs or antibiotics, especially a long period.

Also, changes in liver tissue are caused by metabolic organ damage, viruses, autoimmune hepatitis, cirrhosis, severe weight loss, obesity.

Diffuse changes can occur not only in adults, but also in children as a result of jaundice, enlargement of the liver in certain diseases.


Diffuse liver changes indicate changes in liver tissue that can occur as a result of minor functional disorders or severe organ damage.

When detecting diffuse changes, it is recommended to undergo an additional examination (both liver and other digestive organs) to find out how badly the organ is affected.

Symptoms of the diffuse changes in the liver

It is also worth noting that such changes in the liver are almost asymptomatic. In rare cases, there is a slight pain in the right hypochondrium, severity, in some cases, pain is felt in the right forearm, the skin around the eyes and sclera turn yellow.

Diffuse changes in the liver parenchyma, which are recorded by ultrasound examination, can occur not only in primary liver disease, but also due to certain pathological extrahepatic changes. So, for example, amyloidosis of the liver is quite possible with diabetes mellitus. In this case, the echographic picture will show an increase in the size of the liver due to all its parts, an increase in the echogenicity of the liver tissue with damping in the deep sections, a manifestation of the heterogeneity of the structure as an increase in the graininess of the image, and a slight smoothing of the pattern of the vessels.

Diffusive changes in the liver and pancreas

The liver, as well as the pancreas, is an unpaired organ that does not have a cavity and consists of tissue.

The digestive organs are joined by ducts, so in most cases, a violation of the work of one organ is reflected in the work of the other.

Diffusive changes in the liver and pancreas can occur due to metabolic disorders, vascular diseases, infectious diseases in acute or chronic form.

Disturbance of the liver can be suspected by the yellowness of eye proteins, skin, dark urine, feces of light color. If the liver is malfunctioning, itching of the skin may occur, since a large amount of bile enters the blood.

Change in pancreatic tissue occurs for various reasons: puffiness, pancreatitis, lipomatism (replacement of organ tissues with fat), proliferation and scarring of the tissue due to inflammation or metabolic disorders.

Diffusive changes in the liver and kidneys

Diffusive changes in the liver and kidneys are a multi-faceted concept and are not considered the main diagnosis. This conclusion is based on the results of an ultrasound study.

With some diseases, the structure of the organ changes, in addition, such changes can lead to congenital or acquired pathologies,

With diffuse changes, a thickening of the parenchyma, an increase or decrease in the sinus, an accumulation of fluid in the pelvis, a purulent inflammation, a thrombosis are possible.

In some cases, changes in kidney tissue may be due to the presence of kidney stones.

Diffusive changes in the liver and spleen

Diffuse changes in the liver and spleen affect the body completely.

The spleen is responsible for normal blood circulation, enriched blood flow, with diseases or impaired function of the body there is weakness, decreased appetite, sleep disturbance.

With an increase in the spleen due to irregularities in the work appears soreness, a feeling of pressure. Too large in size, the organ can protrude strongly and press on adjacent organs. Often, the disease of the spleen man is confused with a violation of the pancreas.

The spleen suffers a malfunction, as a rule, due to improper or inadequate nutrition, as a result of which the necessary amount of nutrients and trace elements do not enter the blood and the body independently replenishes the lack of substances. But in such conditions, the spleen's work is quickly broken, resulting in changes in the tissue and structure of the organ.

Diffuse changes in liver parenchyma

The liver tissue has a homogeneous structure with a low density. When diffuse changes in the parenchyma in the liver during ultrasound in the tissues of the liver, blood vessels with bile ducts whose density is increased are seen.

Diffusive changes in the liver indicate a complete change in liver tissue, which can be associated with both serious pathologies and with minor functional impairments in the body.

The degree of edema of the liver parenchyma depends on the severity of the inflammatory process. At diffuse changes the following diseases can be observed: obesity, cirrhosis, diabetes, alcoholism, tumors, chronic hepatitis, cystic formations.

Also parasites or a virus infection, an incorrect delivery are not excluded.

Started diffuse changes in the liver can cause headache, nausea, weakness, bitterness in the mouth, frequent changes of mood, irritability.

Diffusive changes in the structure of the liver

Diffuse liver changes are detected on ultrasound. Changing the structure can begin not only as a result of primary liver diseases, but also in pathologies that are not related to the organ. For example, with diabetes mellitus, there may be a violation of protein metabolism and deposits in the liver will appear.

In this case, the liver shares increase in size, the density of the organ also increases, in the deeper layers the structure of the organ loses its uniformity.

The heterogeneous structure can be viewed as small or large areas of different density with pathological metabolic products (proteins, carbohydrates).

Diffuse changes in liver tissue

With any negative effects on the liver, changes occur in the diffuse tissue of the organ. Such changes can provoke alcohol dependence, smoking, drugs, hereditary anomalies, as well as viruses and bacteria.

Often diffuse liver changes are detected in combination with pancreatic diseases, since these organs are associated with ducts.

Diffusively heterogeneous changes in the structure of the liver

Diffusive changes in the liver, in which there is a heterogeneity of the tissue, can be associated with the obstruction of the ducts of the gallbladder, the proliferation or reduction of connective tissue, the accumulation of any substances in the cells of the liver.

With heterogeneity of the liver, as a rule, diagnosed with cirrhosis, calcifications, obstruction of the liver of the liver, hepatitis, a metabolic disorder (with obesity or diabetes).

Quite often, with a heterogeneous structure of the tissues there are tubercles, the connective tissue decreases or increases, the dystrophy of the liver cells, the bile ducts is not ruled out.

The causes of tissue changes may be related, as already mentioned, to inferior, unhealthy diets, alcohol abuse, etc.

Most of the pathological conditions of the liver are detected by ultrasound.

For the appointment of treatment requires the establishment of a basic diagnosis, which was the cause of diffuse liver changes.

The liver is a unique organ of a person who has the ability to self-repair, but irreversible consequences lead to serious violations in the work of the body.

Diffusively dystrophic changes in the liver

Diffusive liver changes occur as a result of negative effects on the body due to malnutrition, diseases or other irregularities in the functioning of organs and systems.

Dystrophic changes lead to a strong suppression of the hepatic function. The cause of such changes are acute or chronic diseases of the body.

In most cases, dystrophic changes in diffuse tissue are due to the hepatitis virus. In some cases, such poisoning is caused by poisoning (fungi, nitrates, etc.), the use of halothane, atophane.

Also, cirrhosis of the liver, inappropriate use of diuretics, hypnotics or sedatives can lead to such changes.

Diffusive changes in the walls of the liver ducts

The liver consists of lobules, in the center of which pass the veins and bile ducts. The ducts are needed to collect the bile produced, they pass through the entire liver and have closed ends.

Diffuse liver changes affect the entire organ, including the walls of the liver ducts. Changes in the walls of the ducts occur mainly for the same reasons as in the rest of the organ tissue (viruses, bacteria, unhealthy foods, etc.).

Diffuse liver changes in chronic cholecystitis

Diffuse liver changes in chronic cholecystitis occur quite often.

With chronic cholecystitis in the gallbladder, a prolonged inflammatory process is observed, at times with exacerbations. The disease is always secondary, which develops as a result of dyskinesia of bile ducts or congenital pathologies. From cholecystitis women are more often affected (five times), especially with blond hair and prone to fatness.

Diffusive liver changes in hepatomegaly

Hepatomegaly is a pathological enlargement of the liver. The most common cause of this condition is poisoning with toxins or poisonous substances. Diffusive changes in the liver in this case affect completely all tissues, while the organ is easily probed under the ribs (with a healthy liver, it is extremely difficult to feel the organ).

In addition, with pain, pain is felt, which also indicates a disruption of the liver. Hepatomegaly is not considered an independent disease, experts attribute the condition to a symptom that indicates the need to urgently treat the liver.

The liver performs destruction and neutralization of toxic and poisonous substances that enter the body. Passing through the liver, toxins are eliminated from the body by neutralized ones.

Diffuse reactive changes in the liver

Diffuse liver changes are sometimes reactive, in other words, if there is a violation of the liver, a pancreatic reaction is observed, which is expressed by reactive pancreatitis.

Such a conclusion in ultrasound research makes it possible to exclude neoplasms, tumors, stones, etc., with a high degree of likelihood. Ultrasound also shows focal lesions of tissue density.

Diffuse changes are not a diagnosis, they only indicate the need for additional examination.

Diffusive focal liver changes

Diffuse liver changes affect the entire organ. During ultrasound, the doctor diagnoses the change of tissue on the entire surface of the liver. In focal lesions of the organ, changes affect individual areas of the liver, in other words, ultrasound reveals foci of change on normal liver tissue.

In case of diffuse focal changes, the doctor reveals individual foci on the affected liver tissue, which differs from diffuse ones. Such changes occur in hepatitis accompanied by metastasis or abscess.

Diffuse liver changes in the child

Diffusive liver changes can occur as a result of congenital pathologies (underdevelopment). Also, the cause can be a disease with hepatitis during pregnancy (usually in such cases, an interruption of pregnancy is prescribed).

Changes in the liver in a child can begin on the background of antibiotic treatment, which are extremely toxic drugs, and the baby's body is not strong enough and formed.

Diffuse liver changes in a newborn

Diffuse liver changes in newborns often occur as a result of congenital anomalies.

Also on the liver of a newborn can affect the mother's disease during pregnancy, medications (especially antibiotics).

If a diffuse liver change is detected in a newborn, first of all, an additional examination (blood test, urine) should be performed, biochemical blood test, biopsy, laparoscopy if necessary.


Minor diffuse liver changes

Minor diffuse liver changes occur quite often.

The risk of changes in the liver is determined by an additional examination. When the liver is disturbed, the pancreas is almost always disrupted.

With diffuse changes, the hepatitis B and C virus causes enormous damage to the organ. With hepatitis, the liver is unable to cope with its function (neutralize toxins and poisons), which leads to its destruction. Often this problem is aggravated by alcohol or drugs, which ultimately leads to death.

Moderately diffuse liver changes

Moderate diffuse changes in the liver appear under the influence of external factors (poisoning, unhealthy food, etc.). In addition, viruses can have a negative effect on liver cells.

With the beginning of changes in the liver (at any stage), first of all it is recommended to pay attention to food, to exclude, fatty, sweet, salty, etc. Dishes.

When viral infections are prescribed antiviral drugs, in severe cases, inpatient treatment is needed.

If the liver has ceased to cope with its main task, in particular, because of alcohol or synthetic substances, purification of blood is prescribed.

If, after ultrasound, moderate diffuse liver changes have been identified, the course of vitamins, in which a weakened organism needs, should be drunk.

Pronounced diffuse liver changes

The stronger the diffuse changes in the liver, the more puffiness of the parenchyma. Similar changes begin, as already mentioned, with diabetes, obesity (fatty degeneration of the liver), chronic hepatitis, cirrhosis, tumors or cysts (local changes).

Also, experts do not exclude parasites or viral infections, malnutrition, excessive alcohol consumption.

Treatment is appointed after a complete examination and the main cause of diffuse changes.

Diagnostics of the diffuse changes in the liver

Diffuse liver changes are diagnosed, mainly, during ultrasound. However, it is practically impossible to establish the cause of the disease with ultrasound alone, and additional laboratory and instrumental analyzes (general, biochemical blood test, urine, biopsy, computed tomography) are often required.

Echoes of diffuse liver changes

Diffuse liver changes during ultrasound are expressed by reduced echoes and increased sound conduction.

During the study, there is an increased density of the structure of the liver, the union of blood vessels.

Density of the tissue with diffuse changes is revealed throughout the surface of the organ, in some cases, lesions of individual liver regions are also diagnosed.

What do need to examine?

Treatment of the diffuse changes in the liver

Because, diffuse liver changes are a consequence of a disease, treatment depends on establishing the root cause of such changes. Any disease that a person has suffered reflects on the liver, in particular, there may be minor or moderate diffuse changes.

With diffuse changes, the specialist recommends changing the diet, quitting smoking, drinking alcohol. If the reason for the changes was the wrong way of life, the doctor appoints a dietary table number 5.

In viral diseases, antiviral drugs are prescribed, hypoprotectors for the restoration of liver cells.

Alternative methods can also be used that help restore the liver. Often for normalization of the liver use a decoction of chicory, plum juice, a pumpkin with honey, as well as herbal tinctures.

Widely used for the treatment of the liver is the herb milk thistle and the root of the pancake for cooking broth (1 tablespoon herb, 250ml boiling water).

It is also recommended in the mornings on an empty stomach to take 1 tbsp. Pumpkin or olive oil for a month. It is worth noting that during treatment it is important to follow a diet (exclude chocolate, fried, fatty, salty, dishes, soda, etc.).

Diet for diffuse liver changes

If the examination showed diffuse changes in the liver, a "diet table number 5" is prescribed, which is aimed at restoring the liver, bile, and sparing effects on the digestive system.

The diet provides the necessary amount of proteins, carbohydrates, to some extent restricts fats.

Use dishes, as well as drinks should be only in warm or slightly hot form.

The maintenance of the diet depends on the general state of health and the process of recovery.

When detecting diffuse changes, first of all, it is necessary to exclude:

  • Fatty species of poultry (goose, duck), fish, meat
  • patties fried
  • fried, boiled eggs
  • by-products (kidneys, brains, etc.)
  • broth mushroom, meat, fish
  • fresh baked goods (including bread)
  • okroshka
  • Milk and lactic acid foods with high fat content (cheeses, sour cream, etc.)
  • sharp, fried, canned, fatty, smoked products
  • cream cakes, chocolate sweets and chocolate, ice cream
  • green onions, spinach, radish, mushrooms, garlic, sorrel
  • sausages

Diet No. 5 includes:

  • jam, honey
  • yesterday's pastries (including bread), baked patties
  • berries and fruit are not sour varieties, jelly
  • tea or coffee with milk, broth hips
  • fresh, berry, fruit
  • mashed potatoes, vegetables (raw, boiled, stewed)
  • protein omelet, boiled soft boiled egg (1 egg yolk per day)
  • vegetable broths, lean soups, borscht, fruit soups
  • low-fat lactic acid products (low-fat cheeses, acidophilus, curdled milk, etc.) and milk
  • low-fat meat (turkey, rabbit, pork, etc.), boiled sausages


Diffuse liver changes occur because of many reasons. For prevention it is recommended to undergo regular preventive examinations, avoid contact with industrial, poisonous substances, lead a healthy lifestyle and eat right.

Also it is necessary to treat diseases in a timely manner, to follow the doctor's recommendations.


If diffuse liver changes are detected, then the prognosis of this condition depends on the underlying disease, which led to such consequences. If the liver tissue has changed as a result of malnutrition, unhealthy lifestyles, then the prognosis will be favorable if the patient changes his lifestyle (refuses to smoke, alcohol, starts to follow a special diet).

For other reasons, the prognosis depends on the underlying disease, the degree and condition of the patient.

Diffuse liver changes, as a rule, do not pose a serious danger to life and health. Usually such processes begin to occur due to the lifestyle of a person, the habit of eating fast and unhealthy foods and do not cause anxiety.

It is important to know!

In newborns, the cause of extrahepatic presynusoidal hypertension may be omphalitis, including that caused by catheterization of the umbilical vein. The infection spreads through the umbilical vein to the left branch of the portal vein, and then to its main trunk. The children of older age are the cause of acute appendicitis and peritonitis. Read more..

Last reviewed by: Aleksey Portnov , medical expert, on 22.12.2018
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