Diclosan

Diclosan contains the element diclofenac, which is included in the NSAID subgroup; has a strong antirheumatic, anti-inflammatory, antipyretic and analgesic effect. The main principle of its therapeutic effect is the inhibition of the biosynthesis of GHG elements.

During inflammations provoked by rheumatic diseases or injuries, the medication allows you to weaken tissue swelling and pain, as well as reduce the renewal period of the activity of damaged muscles with ligaments, joints and tendons. [1]

Indications Diclosan

It is used for local therapy of inflammation and pain in the area of muscles, tendons with joints and ligaments of traumatic or rheumatic genesis.

Release form

The drug is produced in the form of a gel, inside a tube with a capacity of 40 g. Inside the pack - 1 such tube.

Pharmacodynamics

Clinical evidence confirms that the drug relieves acute pain after 60 minutes from the moment of the first treatment. 94% of those treated after 2 days had a reaction with respect to Diclosan (compared with 8% of those who showed a response to placebo). [2]

Elimination of functional disorders and pain was observed after 4 days of gel therapy. The water-alcohol base of the drug has a cooling and local anesthetic effect. [3]

Pharmacokinetics

The volumes of diclofenac absorbed through the epidermis are proportional to the size of the treated area and depend on the total gel portion used and the intensity of epidermal hydration. When a 500 cm2 epidermal surface was topically treated with 2.5 g of gel, the absorption rate of the substance was approximately 6%. In the case of imposing a sealed dressing for a 10-hour interval, the drug absorption increased threefold.

When the epidermis is treated with gel in the area of the knee and wrist joints, diclofenac is noted inside the blood plasma (its Cmax values are approximately 100 times lower than in the case of ingestion), synovium and synovium. Protein synthesis of drugs - 99.7%.

Diclofenac accumulates inside the epidermis, which is a reservoir from which the drug is gradually released into adjacent tissues. Further, the substance mainly passes into the inflamed tissues located deeper (for example, joints), and continues to influence already there. Here, the drug is registered in concentrations that have a level up to 20 times higher than inside the blood plasma.

The metabolic processes of diclofenac mainly occur during hydroxylation, when several phenolic derivatives are formed (of which 2 have a medicinal effect, but much weaker than diclofenac).

The active element with its metabolic components is excreted mainly in the urine. The systemic intraplasmic drug clearance is 263 ± 56 ml per minute, and the final half-life is 1-3 hours (mean value).

Dosing and administration

It is required to use Diclosan 3-4 times a day; the gel is applied by rubbing it a little into the epidermis. The volume of the applied substance is determined by the size of the inflamed area (for example, 2-4 g of gel is enough to treat an area whose size is 400-800 cm2). 

After completing the application, you should wash your hands (except for situations when this particular area is being treated).

The duration of the treatment cycle is determined by the therapeutic efficacy of the gel and the nature of the pathology.

Do not use the gel for more than 2 consecutive weeks.

• Application for children

You can not prescribe medicine to persons under the age of 14. In the case of using drugs in adolescents from 14 years of age for a period longer than 1 week, or when potentiating the signs of the disease, you need to consult a doctor.

Use Diclosan during pregnancy

There is too little clinical information regarding the use of drugs in pregnant women, which is why the gel is not prescribed during the indicated period, as well as for HB. The absolute contraindication to use is the 3rd trimester, since Diclosan can provoke weakness of labor activity or premature closure of the arterial pathway.

When tested with animals, no negative effects on pregnancy, embryo development, labor and postnatal development were found.

In the case of strict indications, the medication can be used while breastfeeding - in situations where the likely benefits are more expected than the various risks. You can not treat the breast glands with the gel, as well as use it for a long time.

Contraindications

The main contraindications:

• severe intolerance associated with diclofenac or other elements of the drug;
• a history of cases with asthma, acute rhinitis or urticaria, which developed due to the administration of aspirin or other NSAID substances.

Side effects Diclosan

Among the side signs:

• invasive or infectious infections: occasionally a pustular rash appears;
• disorders of the immune function: occasionally there is Quincke's edema or symptoms of intolerance (among them urticaria);
• respiratory problems: occasionally asthma occurs;
• lesions of connective tissues and epidermis: itching, dermatitis (also its contact form), rashes, erythema and eczema are often noted. Occasionally, there is a burning sensation or manifestations of photosensitivity. Bullous dermatitis develops singly.

Overdose

The risk of developing intoxication is very low, because diclofenac is extremely poorly absorbed into the systemic circulation in the case of local treatment. If the gel is swallowed inside, there may be general side effects.

In case of accidental oral intake of drugs, it is necessary to quickly induce vomiting and use an adsorbent. Symptomatic actions are carried out with the implementation of procedures that are prescribed for the treatment of intoxication with NSAID drugs.

Storage conditions

Diclosan must be kept in a place closed from the penetration of small children. Temperature values are not higher than 25 ° С.

Shelf life

Diclosan can be used within 24 months from the date of manufacture of the therapeutic substance.

Analogs

Analogs of the drug are Nimid, Diclobene with Dolgit gel, Butadion and Ketoprofen with F-gel, and in addition Diclofenac, Finalgel and Clafen with Rewmalin.