Dibazol

Dibazol has myotropic, antispasmodic, vasodilating and short-term hypotonic activity.

[1], [2], [3], [4]

Indications Dibazole

It is used in the presence of spasms in the area of smooth muscles of vascular tissues. It can also be used to eliminate hypertensive crisis. In the case of spasm of smooth muscles of internal organs (ulcers, intestinal colic, cholecystitis or pancreatitis), the reduction of pain is achieved by relaxing them.

It can also be prescribed for neurological pathologies: atrophic paralysis syndrome, elimination of residual symptoms of polio and Bell's paralysis.

Dibazol tablets are often prescribed for gastroenterological, neurological and cardiological diseases.

[5], [6]

Release form

The release of the substance is realized in tablets, which in the amount of 10 pieces are packed in a cell-free blister.

It is also produced as an injection liquid, inside ampoules having a capacity of 2 ml. In the box - 10 such ampoules.

[7]

Pharmacodynamics

The active element of the drug has an effect on the smooth vascular muscles of the internal organs, as well as arterioles with venules. The drug can weaken the vascular tone of the circulatory system, reducing blood pressure indicators and potentiating blood flow to the area of the myocardium affected by hypoxia and ischemia, which develop with coronary artery disease.

The bendazole component can stimulate synaptic movement between spinal neurons, so the drug can be used in neurology.

The active ingredient can also have an immunomodulatory effect, because it has similarities with levamisole, which is classified as an immune stimulant drug. Immunostimulating activity of drugs develops due to the fact that bendazole may potentiate the production of endogenous interferon.

[8]

Pharmacokinetics

Dibazol has good absorption inside the digestive system. Metabolic processes lead to the formation of 2 key active metabolic products. The development of medical influence is determined after 0.5-1 o'clock; The effect can last about 3 hours.

Excretion is mainly done by the kidneys; a small part of the metabolic products of the drug is excreted through the intestines.

[9], [10]

Dosing and administration

Tablets are prescribed at a dosage of 20-50 mg 2-3 times a day, for 3-4 weeks. Children should consume 1-5 mg of the substance 1-fold per day (the size of the portion is selected taking into account the age of the child).

In neurology, the drug is used as follows: in a dose of 5 mg per day with the use of a day; The whole cycle lasts 5-10 days. Repeat therapy is necessary after 3-4 weeks. Further, the treatment is repeated at 1-2-month intervals.

To eliminate the hypertensive crisis, a substance is introduced from ampoules, in portions of 30-40 mg. Intravenous or intramuscular injections are performed. If there is a significant increase in blood pressure values and exacerbation of arterial hypertension, Dibazol is administered at a dosage of 20-30 mg intramuscularly, 2-3 times a day. The whole cycle lasts 8-14 days.

[14]

Use Dibazole during pregnancy

Dibazol is allowed to be used in pregnant women in situations where it is assumed that its benefits are more likely than the risk of complications in the fetus.

From breastfeeding should be abandoned at the time of use of drugs.

Contraindications

Among the contraindications:

• personal intolerance against bendazole;
• tablets with a volume of 20 mg should not be prescribed to children;
• low blood pressure;
• ulcers in the gastrointestinal tract, accompanied by bleeding;
• diseases affecting the kidney system;
• failure of cardiac work in the severe stage;
• diabetes;
• reduced muscle tone.

Caution is required when using the elderly (especially a long time). It is also very carefully applied to people who need enhanced concentration and attentiveness at work, because therapy can cause dizziness and movement coordination disorder.

[11],

Side effects Dibazole

The drug is usually transferred without the development of complications, only occasionally there are changes in ECG indices caused by a change in the fraction of left ventricular ejection. In people with a predisposition, symptoms of allergies, dizziness and lower blood pressure values may appear.

After intravenous use of the drug, pain may appear at the injection site.

[12], [13]

Overdose

The use of too high portions of the drug leads to the appearance of such negative symptoms: a feeling of heat, dizziness, hyperhidrosis, a decrease in blood pressure and nausea.

The drug does not have an antidote, therefore, in case of intoxication, it is first necessary to reduce the absorption of the active substance inside the gastrointestinal tract, inducing vomiting, performing gastric lavage and prescribing the use of chelators (activated carbon, smect or polysorb, etc.). If there is a different clinical symptoms, perform step-by-step symptomatic procedures.

[15], [16]

Interactions with other drugs

There is a potentiation of the severity of the hypotensive effect of drugs when combined with diuretic drugs and antihypertensive drugs.

Bendazol can prevent an increase in OPSS values that develop after the use of β-blockers.

The antihypertensive activity of Dibazol is potentiated when used together with phentolamine.

[17], [18]

Storage conditions

Dibazol is required to be kept in a dark place, with temperature indices constituting not more than 30 ° C.

Shelf life

Dibazol as an injection liquid can be used within a 4-year period from the moment the substance is manufactured, and tablets have a 5-year shelf life.

Application for children

Older children are prescribed pills with a dosage of 4 mg, and babies need to make special solutions (this happens in the designated pharmacy points). In pediatrics, Dibazol is used for such disorders:

• muscle hypotension due to severe delivery due to prolonged hypoxia, diseases of the neuro-muscular system of hereditary nature, and various syndromes of the chromosomial type;
• cramps with colic. The drug has a mild effect on smooth muscles, eliminating the pain associated with spasms of the tissues of the smooth muscles of the internal organs;
• fatigue and stress. The drug has adaptogenic properties, thereby helping to strengthen the nonspecific protective function of the body of the child;
• SARS, flu and cold. The drug potentiates the production of interferon after the penetration of the virus into the child's body.

[19], [20], [21],

Reviews

Dibazol for the most part receives positive feedback from patients using it. Parents note that the drug quickly eliminates colic that occurs in children in the case of smooth muscle spasms. Other patients report that the drug quickly lowers blood pressure in the event of a hypertensive crisis.

Only occasionally it is said about the development of negative symptoms, because Dibazol is intended for situational use, it cannot be used for long courses.