Dexon

Drug Dexon is a combination drug, the effect of which is due to the content of corticosteroid and antimicrobial components. Dexon is available in the form of ear / eye drops.

[1], [2]

Indications Dexon

Dexon is intended for short-term therapy of infectious (microbial) inflammatory processes in the eye organs and external ear.

The drug is not advisable to prescribe to eliminate fungal or viral pathology of the eye and / or ear.

Direct indications for the appointment of Dexon are:

• blepharitis of microbial etiology;
• conjunctivitis of microbial etiology;
• keratitis (without epithelial tissue damage) of the microbial etiology;
• irit, iridocyclitis of microbial etiology;
• prevention of inflammatory processes in the anterior eye department after surgery;
• acute or chronic form of external otitis media;
• Microbial or allergic pathology concerning the external ear.

[3], [4], [5]

Release form

Dexon is a medicinal drop based on dexamethasone (corticosteroid hormone) and neomycin (an antimicrobial agent). Drops have the appearance of a clear solution - almost colorless or slightly yellowish.

Packing from cardboard contains one bottle, which is equipped with a tip-dropper. The volume of the bottle is 5 ml.

[6], [7]

Pharmacodynamics

Active Ingredients Dexon is dexamethasone and neomycin.

Dexamethasone is a glucocorticoid hormone with anti-inflammatory, antiallergic, antipruritic action. If this substance is used topically, then it is possible to reduce the painful manifestations, burning, and also to get rid of lacrimation and photophobia.

Neomycin is an antibiotic aminoglycoside, with a broad spectrum of antimicrobial activity. In fact, this drug is a combination of neomycins formed as a result of the activity of streptomycete fungus. The main property of neomycin is bactericidal. It is explained by the action on the ribosomes and inhibition of the production of the protein of the microbial cell. Neomycin is active against gram (-) and gram (+) bacteria, in particular, to shigella, proteus, mycobacteria, streptococci.

The drug Dexon is used externally, for diseases of the eyes and skin. The persistence of microbes to the medicament develops gradually and to an insignificant degree.

[8], [9], [10], [11]

Pharmacokinetics

After applying drops to the zone of the conjunctival sac, the glucocorticoid easily penetrates the epithelial corneal and conjunctival tissue. The limiting therapeutic quantities of the drug are found in the cornea, anterior eye chamber and in the vitreous. Dexamethasone quickly enters the eye fluid: therapeutic concentrations are observed for 90-120 minutes.

Anti-inflammatory effect after drop application Dexon lasts up to 4-8 hours. Absorption of the drug into the total blood flow with external application is not of clinical significance.

Neomycin - the bactericidal component of the drug Dexon - is not absorbed through intact skin.

[12], [13], [14]

Dosing and administration

The scheme of therapy is determined by the doctor, depending on the complexity of the inflammation and the response of the pathology to the medicine Dexon.

• For the treatment of the organs of vision, 1-2 drops of the drug are used every 1-2 hours during the day and every 2 hours at night. After completion of the acute phase, the dosage is reduced to 1 drop 5 times per day. The maximum allowable dosage is 30 drops per day per eye. Therapy continues for 7-10 days.

With chronic eye pathology, Dexon drip 1 drop twice a day, with a treatment duration of 14-28 days.

• For the treatment of auditory organs, droplets drip into the external auditory orifice. Before the drops are applied, the auditory passage is cleaned and wiped with a cotton disc. Optimum initial dosage Dexon can be 3-4 drops up to 3 times a day. After the relief of the condition, the dosage is gradually reduced to the complete cessation of treatment, which usually lasts 7-14 days. The limiting dose per day is 12 drops per ear.

[26], [27], [28], [29], [30], [31]

Use Dexon during pregnancy

Information regarding the use of drops of Dexon during pregnancy and breastfeeding is absent. Since the safety of this drug is not officially confirmed, it is recommended to refrain from using it in the periods listed.

Contraindications

Dexon is contraindicated:

• with tuberculosis lesions of the eye or ear organs;
• with herpetic and other viral damage of the eye and ear organs;
• with a purulent form of conjunctivitis with the development of resistance of bacteria to neomycin;
• with a purulent corneal ulcer;
• with glaucoma;
• with cataract;
• with fungal infection of the eye or ear organs;
• with perforation of the tympanic membrane;
• with diagnosed hypersensitivity to the composition of the drug Dexon;
• during pregnancy and during breastfeeding.

[15], [16], [17], [18], [19], [20], [21], [22]

Side effects Dexon

With external application of drops of Dexon, such side effects can occur:

• uncomfortable sensation inside the eye (burning, sensation of foreign body);
• allergic processes;
• irritation, dermatitis;
• swelling, redness of the eyelids;
• lacrimation;
• transient visual impairment;
• transient narrowing of the field of vision;
• increased intraocular pressure;
• perforation of the cornea;
• omission of the eyelid;
• development of keratitis;
• photophobia;
• posterior subcapsular cataract;
• development of glaucoma.

With prolonged treatment with Dexon, the risk of attaching microbial, viral and fungal lesions to the visual organs or the ear may increase.

[23], [24], [25]

Overdose

When using large doses, Dexon is likely to increase the side effects, in particular:

• hyperemia of the eye mucosa;
• burning sensation;
• lacrimation;
• swelling of the eyelid;
• point keratitis.

If you suspect an overdose, Dexon is advised to rinse the eye or ear with warm running water.

[32], [33], [34], [35], [36], [37]

Interactions with other drugs

Do not administer Dexon drops in combination with monomycin or streptomycin, as this can lead to a strong ototoxic effect.

Information regarding other medicinal interactions of the drug Dexon is absent.

[38], [39], [40], [41], [42], [43]

Storage conditions

The Dexon drops are stored at temperatures up to + 25 ° C, in a dark and inaccessible place for children.

Dexon should not be subjected to freezing.

[44]

Shelf life

Dexon is stored for up to 3 years in a sealed factory package. After opening the bottle, the shelf life is reduced to 1 month, after which the drug is considered unfit for use.

[45], [46], [47], [48]