Dexon

The drug Dexon is a combination drug, the action of which is due to the content of corticosteroid and antimicrobial components. Dexon is available in the form of ear/eye drops.

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Indications Dexon

Dexon is intended for short-term treatment of infectious (microbial) inflammatory processes in the eye organs and outer ear.

It is not advisable to prescribe the drug to eliminate fungal or viral pathology of the eyes and/or ear.

Direct indications for the use of Dexon are:

• blepharitis of microbial etiology;
• conjunctivitis of microbial etiology;
• keratitis (without damage to epithelial tissue) of microbial etiology;
• iritis, iridocyclitis of microbial etiology;
• prevention of inflammatory processes in the anterior eye region after surgery;
• acute or chronic form of otitis externa;
• microbial or allergic pathologies affecting the outer ear.

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Release form

Dexon is a medicinal drop based on dexamethasone (a corticosteroid hormone) and neomycin (an antimicrobial agent). The drops look like a transparent solution - almost colorless or slightly yellowish.

The cardboard packaging contains one bottle, which is equipped with a dropper tip. The bottle volume is 5 ml.

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Pharmacodynamics

The active ingredients of Dexon are dexamethasone and neomycin.

Dexamethasone is a glucocorticoid hormonal substance with anti-inflammatory, anti-allergic, antipruritic action. If this substance is used locally, it can reduce painful manifestations, burning, and also get rid of lacrimation and photophobia.

Neomycin is an aminoglycoside antibiotic with a broad spectrum of antimicrobial activity. In essence, this drug is a combination of neomycins formed as a result of the vital activity of the streptomycete fungus. The main property of neomycin is bactericidal. This is explained by the effect on ribosomes and inhibition of the production of microbial cell protein. Neomycin is active against gram (-) and gram (+) bacteria, in particular, shigella, proteus, mycobacteria, streptococci.

The drug Dexon is used externally, for diseases of the eyes and skin. The resistance of microbes to the drug develops gradually and to a small extent.

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Pharmacokinetics

After applying drops to the conjunctival sac area, the glucocorticoid easily penetrates the epithelial corneal and conjunctival tissue. The maximum therapeutic amounts of the drug are found in the cornea, anterior chamber of the eye, and vitreous body. Dexamethasone quickly enters the eye fluid: therapeutic concentrations are observed here for 90-120 minutes.

The anti-inflammatory effect after applying Dexon drops lasts up to 4-8 hours. The absorption of the drug into the general bloodstream when applied externally has no clinical significance.

Neomycin, the bactericidal component of Dexon, is not absorbed through intact skin.

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Dosing and administration

The treatment regimen is determined by the doctor depending on the complexity of the inflammation and the reaction of the pathology to the drug Dexon.

• To treat the organs of vision, use 1-2 drops of the medicine every 1-2 hours during the day and every 2 hours at night. After the acute phase is over, the dosage is reduced to 1 drop 5 times a day. The maximum permissible dosage is 30 drops per day per eye. Therapy continues for 7-10 days.

For chronic eye pathology, Dexon is instilled 1 drop twice a day, with a treatment duration of 14-28 days.

• To treat the hearing organs, drops are dripped into the external auditory canal. Before applying the drops, the ear canal is cleaned and wiped with a cotton pad. The optimal initial dosage of Dexon can be 3-4 drops up to 3 times a day. After the condition has eased, the dosage is gradually reduced until the treatment is completely stopped, which usually lasts 7-14 days. The maximum daily dose is 12 drops per ear.

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Use Dexon during pregnancy

There is no information regarding the use of Dexon drops during pregnancy and breastfeeding. Since the safety of this drug has not been officially confirmed, it is recommended to refrain from using it during the periods listed.

Contraindications

Dexon is contraindicated:

• in case of tuberculous lesions of the eye or ear organs;
• for herpes and other viral infections of the eyes and ears;
• in purulent conjunctivitis with the development of bacterial resistance to neomycin;
• for purulent corneal ulcer;
• for glaucoma;
• for cataracts;
• in case of fungal infection of the eyes or ears;
• in case of perforation of the eardrum;
• in case of diagnosed hypersensitivity to the composition of the drug Dexon;
• during pregnancy and breastfeeding.

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Side effects Dexon

When applying Dexon drops externally, the following side effects may occur:

• an uncomfortable sensation inside the eye (burning, foreign body sensation);
• allergic processes;
• irritation, dermatitis;
• swelling, redness of the eyelids;
• lacrimation;
• transient visual impairment;
• transient narrowing of the visual field;
• increased intraocular pressure;
• corneal perforation injury;
• drooping eyelid;
• development of keratitis;
• photophobia;
• posterior subcapsular cataract;
• development of glaucoma.

With long-term treatment with Dexon, the risk of developing microbial, viral and fungal lesions of the visual organs or ear may increase.

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Overdose

When using high doses of Dexon, there is a possibility of increased side effects, in particular:

• hyperemia of the ocular mucosa;
• burning sensation;
• lacrimation;
• eyelid swelling;
• punctate keratitis.

If you suspect an overdose of Dexon, it is recommended to rinse the eye or ear thoroughly with warm running water.

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Interactions with other drugs

Dexon drops should not be prescribed in combination with monomycin or streptomycin, as this may lead to a strong ototoxic effect.

There is no information regarding other drug interactions with Dexon.

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Storage conditions

Dexon drops are stored at a temperature of up to +25°C, in a dark place out of the reach of children.

Dexon should not be exposed to freezing.

Shelf life

Dexon is stored for up to 3 years in sealed factory packaging. After opening the bottle, the shelf life is reduced to 1 month, after which the drug is considered unsuitable for use.

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