Isolate

At some pathological processes in a human body considerable loss of a liquid that threatens with a dehydration is observed. Lack of water in the body in turn provokes the development of serious diseases due to the destruction of the immune system. The kidneys, the liver suffer, the arterial pressure increases, the cartilaginous tissue is destroyed, etc. One glass of water can not solve this problem. Therefore, doctors resort to the help of rehydration therapy drugs, one of which is "Isolate".

[1]

Indications Isolate

Based on the composition of the drug "Isolate" you can understand that this drug has a fairly wide range of indications for use.

The most common cause of a large loss of body fluids are digestive disorders, accompanied by vomiting and uterus of stool (diarrhea, or in a simple diarrhea). In this situation, a large amount of fluid is eliminated from the body through the intestine in the liquid stool. This occurs as a result of banal poisoning or for a number of other reasons.

For the preparation "Isolate" it does not matter what caused diarrhea. In indications for the use of the drug, diarrhea of any etiology is indicated.

Also, the drug is designed to fill the deficiency in the body of sodium, so necessary for the normal operation of the central nervous system. When the concentration of sodium in the blood plasma drops below the norm (150 mmol per liter), the nervous system suffers first. If the concentration becomes less than 135 mmol per liter, doctors say about the pathological process, which caused hyponatremia.

Sometimes hyponatremia is diagnosed in the postoperative period, which also requires treatment. "Isolate" remains relevant in this case.

Violations of the acid-base balance in the body, observed in intestinal disorders, fever, diabetes, pregnancy and in some other cases, are often caused by an inadequate metabolism of acids. Milk, acetoacetic, oksimoslyanskaya and other non-volatile acids, accumulating in the blood, can cause acetonuria, and in the case of diabetes, even provoke a diabetic coma.

To prevent such a condition in diabetes, called diabetic metabolic acidosis, just help the solution "Isolate".

[2]

Release form

This drug, as you might expect, has only one form of release. It is produced in the form of a solution, packaged in plastic bottles of 0.5 liters. For convenience of use, the vials with solution are provided with a dropper.

Medicinal saline is prepared on pyrogen-free water, which does not contain substances that can cause a fever in the patient or other undesirable reactions. The solution is sterile and completely ready for use.

In addition to the water itself, as part of the solution for infusion "Isolate" (500 ml), there are:

• sodium acetate (sodium salt of acetic acid to create an alkaline medium) - 3200 mg,
• sodium chloride (sodium salt of hydrochloric acid - the usual for us saline solution for the dilution of medicines) - 2500 mg,
• potassium chloride (the potassium salt of hydrochloric acid regulates the acid-base balance and replenishes the lack of potassium in the body) - 375 mg,
• sodium citrate (sodium salt of citric acid - regulator of water-electrolyte and acid-base balance of the body) - 375 mg,
• calcium chloride (calcium chloride regulates the calcium content in the body, which is eluted during a large loss of fluid) - 175 mg,
• magnesium chloride (magnesium chloride to compensate for magnesium deficiency in the body, together with calcium chloride act as a detoxification agent) - 155 mg.

Pharmacodynamics

"Isolate" refers to the category of extracellular replacement solutions, it acts as a substitute for extracellular fluid lost as a result of a pathological process in the body. The solution contains all the electrolytes needed by the body, which are present in the blood plasma, plus a double concentration of potassium and bicarbonate ions.

The content of sodium and chlorine ions in the preparation is such that this preparation can be safely used instead of the physiological solution used to dissolve the drugs administered by the drop route.

Pharmacodynamics most often used to fill the fluid deficiency in connection with various pathological processes in the body, as well as to correct the acid-base balance, disrupted due to poor acid metabolism.

With diarrhea, the drug not only effectively fights the dehydration of the body, but also has a detoxification effect due to the presence of its antidote (calcium and magnesium chloride). 

Pharmacokinetics

Pharmacokinetics of the drug is difficult to study, because "Isolate" is a multicomponent solution, each component of which has its own kinetic features.

[3], [4], [5], [6]

Dosing and administration

Applies the solution "Isolate" only for intravenous infusions (droppers) in a hospital. Dosage for adults varies from 1 to 3 liters per day. The child's dosage, if necessary, is established by the attending physician.

The maximum injection rate of the drug is 500 ml of the solution in 30-45 minutes. But most often the solution is injected at a lower rate.

Use Isolate during pregnancy

The instructions say nothing about the use of "Isolate" during pregnancy, also in childhood. So, these questions remain in the competence of the doctor.

Contraindications

Due to the high content of mineral supplements (magnesium, potassium, sodium, calcium), the drug is not recommended if the patient is diagnosed with renal failure.

Among other contra-indications to application it is possible to allocate:

• Hypoparathyroidism. This condition is characterized by an inadequate production of parathyroid glands of parathyroid hormone, which provokes a pathological decrease in the level of calcium in the blood because of its insufficient washing out of the bones.
• Non-diabetes mellitus, which is a rare disease caused by the inadequate production of the antidiuretic hormone vasopressin by the hypothalamus as a result of malfunctioning of the hypothalamus or pituitary gland.
• Hyperalkalosis is one of the varieties of acid-base balance disturbances in the body, when blood has overestimated pH, i.e. Alkalization of the organism takes place.

[7]

Side effects Isolate

As for the side effects of the drug, the main unpleasant moments of the intake of a large amount of fluid into the body is the need to remove it, which is not so easy to do if a dropper is prescribed for 3 or more hours.

Side effects of the solution "Isolate" can be observed if its intended purpose, as a result of which the level of calcium, potassium and sodium in the blood plasma is significantly increased in comparison with the initial parameters (hyperkalaemia, hypernatremia, hypercalcemia). Similar effects can be observed if the drug is administered to patients with kidney failure.

[8], [9]

Overdose

No cases of drug overdose have been described.

Interactions with other drugs

There is no information on the interaction of "Isolate" with other drugs, but this solution should be carefully administered during the treatment with potassium, calcium and magnesium preparations so that therapy does not lead to an excess of these trace elements in the blood, which is no less dangerous than their lack.

[10], [11]

Special instructions

The drug is undesirable to appoint the patient, in whom pathologies associated with excess minerals, which are part of the solution in the form of salts, are diagnosed.

If there is a lack of sodium in the patient's body, it makes sense to fill its deficiency by introducing the drug "Isolate" with a 0.9 percent solution of sodium chloride.

If there is no pronounced edematic "Isolit" syndrome with hyponatremia, it should be administered with 5 and 0.9% sodium chloride solution.

If there is a need to replenish the body with potassium, before using the drug, you need to make sure that the kidney function is not violated by going through certain examinations.