Dermovayt

Dermovayte is a drug from the GCS category with a local application.

[1], [2], [3]

Indications of the dermovite

It is used to eliminate such problems:

• eczema in different forms;
• red flat lichen;
• psoriasis;
• lupus erythematosus discoid;
• diseases affecting the skin, and resistant to therapy with less active local GCS.

Ointment Dermovajt it is required to use for treatment of dermal pathologies at which dryness, a hyperkeratosis, and also a thickening of an integument is observed - therefore as thanks to the ointment base it is possible to keep a moisture inside a dermal layer.

The cream should be prescribed in situations opposite to the above - in diseases during which there is inflammation of a pronounced nature, against which there is moknutie.

[4],

Release form

Release of the medication occurs as an ointment or cream, in a tube with a capacity of 25 g. Inside the box - 1 tube with cream or ointment.

[5],

Pharmacodynamics

Due to the treatment with a drug, the possibility of the marginal location of neutrophils inside the channel of the vessels is prevented. In addition, the production of lymphokines together with the inflammatory exudate is reduced and the movement of macrophages is prevented.

The intensity of infiltration and granulation processes decreases - the medicine has a local effect of antiallergic, antiexudative, and also antipruritic.

[6],

Pharmacokinetics

The mean peak values of clobetasol are noted inside the plasma after 13 hours from the first treatment of healthy skin with 30 grams of ointment (or after 8 hours after re-treatment). This figure is 0.63 ng / ml.

After re-treatment of 30 grams of cream, the peak values of the substance on average are higher than that after treatment with ointment. Cmax is observed after 10 hours.

With a single treatment of 25 grams of LS in the form of an ointment in people with psoriasis or eczema, after 3 hours, the average peak value inside the plasma is 2.3 and 4.6 ng / ml, respectively.

The metabolic processes that take place with the active element of the drug have not yet been thoroughly studied.

[7]

Dosing and administration

Treat a thin layer of ointment or cream followed by affected areas of the skin, 1-2 times / day, taking into account the severity of the disease.

The cream is more expedient to use at illnesses with strong inflammatory process and moknutie, and the ointment is more suitable for elimination of pathologies, against which the dryness of an integument develops.

The duration of the course is selected for each individual, taking into account the diagnosed disease and the degree of its severity. But at the same time it can last no longer than the 1st month, if there is no need for its extension.

With exacerbation of already previously treated skin pathologies, short repeated courses can be prescribed.

If the external symptoms of the disease disappeared incompletely, after completing the course using Dermovayte, you should switch to more moderate local drugs from the GCS category.

In extremely severe forms of skin surface damage (especially with hyperkeratosis) it is possible to increase the anti-inflammatory effect of the drug by applying a polyethylene film to the affected area (it should be left overnight). The hermetically sealed bandage is then applied to the affected area in order to achieve a more potent therapeutic effect. If the result is obtained, it is allowed to continue therapy without using a sealed bandage.

It is recommended to apply for a week not more than 50 grams of the drug.

Use of the dermovite during pregnancy

Use a cream or ointment pregnant can only be with the permission of the treating doctor. And in this case, in any case, in this period should not use local GCS in large portions and over a long period of time.

There is no information on the safety of using Dermovayt for breastfeeding.

Contraindications

The main contraindications:

• skin cancer;
• common acne;
• gnawing prurigo of Gaida;
• itching in the perianal and genital area;
• perioral dermatitis;
• psoriasis of plaque or common pustular type;
• infants less than 1 year old;
• diseases affecting the surface of the skin, and having a viral, fungal or bacterial origin (among them common herpes, chickenpox, cutaneous tuberculosis and radiation);
• the presence of intolerance in relation to the elements of the drug.

[8], [9]

Side effects of the dermovite

With local use of the drug, hypersensitivity was noted only in single cases.

Local symptoms of intolerance are manifested in this way: in the form of erythema, rashes, hives, itching and burning, and besides this contact form of dermatitis, which is of allergic origin. These signs appear on the areas of drug treatment and are similar to the painful manifestations, for the elimination of which the drug was administered.

If the patient develops signs of intolerance, the use of the medication should be discarded.

In isolated situations, there were signs of hypercorticism (endocrine disruption). They developed if too large portions of cream or ointment were applied, and besides, when treating Dermoveit with too large areas of skin, such actions led to an increase in the systemic absorption of the active element of the drug. Similar symptoms are most often observed in children and infants, but in addition when applying the drug for an occlusive dressing. It must be remembered that in a nursing baby a diaper can act as an occlusive bandage.

If the medicine in a dose not exceeding 50 g for 7 days was used for an adult, suppression of the adrenal glands or pituitary gland is transient. The normal values of these organs are returned after the completion of a short treatment course using local GCS.

Occasionally, the use of drugs leads to the expansion of the surface vessels of the systemic blood flow - this is especially often observed when the preparation is too heavily rubbed into the skin folds, and also when sealed bandages are used.

Disorders from the subcutaneous layer and skin surface are sometimes manifested in the form of atrophy with atrophic bands. The main signs of pathology are exacerbated, and in addition, the thinning of the skin, the change in its pigmentation and the development of psoriasis of the pustular nature or hypertrichosis are noted. Similar symptoms also often occur due to rubbing of the ointment / cream in the area of skin folds or the use of hermetically sealed dressings.

[10]

Overdose

Because Dermoveit in both its forms of release is used only externally locally, the probability of the appearance of signs of acute intoxication is extremely small.

If chronic poisoning has developed due to prolonged use of drugs (or at high dosages), hypercorticoid syndrome may occur - in this case, it is necessary to reduce the size of a portion of the drug or to cancel treatment with the use of local GCS. Cancellation of treatment should be carried out under the supervision of the attending doctor, because there is a risk of developing adrenocortical insufficiency.

[11],

Interactions with other drugs

Since Dermovayt is used exclusively externally, no significant clinical interaction with other medications has been observed.

[12], [13]

Storage conditions

Dermovajt it is required to contain in conditions usual for medicines. Temperature - no more than 30 ° С.

Shelf life

Dermoveit is allowed to be used for 2 years from the date of release of the drug.

[14]

Application for children

Since the use of drugs can cause oppression of the adrenal cortex, it is prohibited to use it in children for a long period of time and at high dosages.

If the child uses Dermovayt or any other local SCS, a minimum medical examination is required at least once a week.

[15]

Analogues

Analogues of this medication are usually prescribed if it is required to switch to more moderate treatment, or to those people who, due to some reasons, this drug does not fit.

Among the proposed analogues of this medication are such substances with local effects: Lokoid with Tricort and Laticort, and also Afloderm and Fluorocort.

[16], [17],

Reviews

Dermovayte is used to eliminate a variety of pathologies that affect the skin (among such psoriasis). The testimonies indicate that the medicine shows good results, quickly relieving the symptoms, and further completely eliminating all the external signs of the disease. Positively responded to both ointments and cream.

Although it should be noted that in medical forums it is often reported that the drug does not show the above high effectiveness in the case of recurrence of the disease (eczema or psoriasis).

It should also be noted that frequent use of the drug, especially in high doses, can provoke the development of resistance of the organism in its relation. Therefore, it is recommended to apply ointment or cream only in the least effective portions (in particular, this applies to the treatment of young children).