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Last reviewed by: Aleksey Portnov , medical expert, on 13.03.2019

Depress is an antidepressant-psychoanaleptic. Included in the category of drugs SSRIs. The active ingredient is fluoxetine.

Indications of the depression

It is used for: depression, having a different origin, OCD and bulimia.

Release form

Release in capsules, 8 pieces inside a blister pack. In a separate pack contains 2 blisters with capsules.


Depres is an antidepressant, a derivative of propylamine. By its chemical composition, it differs from tricyclics and four-cycle antidepressants. The effect of the drug is due to a slowdown in the process of reverse serotonin uptake by neurons inside the CNS. The active component prevents serotonin capture, but does not affect norepinephrine.

The medicine helps to improve mood, remove dysphoria, and also reduce the feeling of tension and fear. Does not have sedative properties. In case of consumption in moderate medicinal doses, it almost does not affect the work of SSS and other systems.


When using a single dose of drugs at a rate of 40 mg, the active component peaks within the plasma for a period of 6-8 hours (15-55 ng / ml). Eating does not change the level of bioavailability of the drug, although the absorption of the substance may be delayed. Synthesis with a plasma protein is 94.5%.

Fluoxetine undergoes rapid hepatic metabolism, which results in the formation of the substance norfluoxetine and other inactive decay products. The medicine is then excreted through the kidneys. The half-life of the active ingredient is 2-3 days, and the active decay product, norfluoxetine, is 7-9 days.

The half-life of fluoxetine with norfluoxetine is prolonged in people with liver failure. Long-term treatment in people with severe form of this pathology can cause accumulation of the substance.

Use of the depression during pregnancy

Depres is forbidden to appoint pregnant women.


The main contraindications:

  • hypersensitivity to fluoxetine;
  • kidney failure in severe degree (glomerular filtration rates are less than 10 ml / min);
  • combined use with MAOI, as well as use of drugs in the period less than 2 weeks before the start of MAOI;
  • the period of breastfeeding;
  • age younger than 18 years (constituent elements of the drug are dyes, which are forbidden to children under the age of 18 years).

Side effects of the depression

Taking medication can lead to the development of certain side effects.

Often observed:

  • rash with itching, anaphylactoid manifestations, chills with vasculitis, urticaria, photosensitivity and angioedema;
  • vomiting, dysphagia, diarrhea, dyspeptic phenomena, nausea, dryness of the oral mucosa and a disorder of taste buds;
  • sleep problems and insomnia, headaches, anorexia and dizziness, drowsiness, fatigue, nervousness, anxiety, excitement or euphoria, temporary pathological conditions (such as tremor and ataxia or myoclonia), mania, impaired concentration and development of depersonalization, the appearance of a psychomotor instability, convulsions and hallucinations, as well as panic attacks (such symptoms may be part of the disease);
  • disturbances of urination processes, erectile dysfunction (delay of ejaculation or its absence, as well as anorgasmia), and in addition galactorrhea or priapism;
  • the appearance of yawning or the development of alopecia;
  • hyperhidrosis, visual disorders (mydriasis or blurring of vision), as well as vasodilation;
  • myalgia or arthralgia, the appearance of bruising, the development of hyponatremia or orthostatic hypotension.

Occasionally arise: pharyngitis, functional hepatic diseases and disorders in the work of respiratory organs.

Single appears: serotonin intoxication, Lyell's syndrome, idiopathic type hepatitis, bleeding in the gastrointestinal tract or gynecological nature, as well as other bleeding in the areas of mucous membranes and skin.

Dosing and administration

For adults.

The size of the daily required dosage for depression or OCD is 20 mg, which must be taken in the morning. If there is no effect after 3-4 weeks of the course, it is allowed to increase the daily dose to 80 mg. Dosages that exceed 20 mg per day need to be divided into 2 receptions, morning and evening.

With bulimia, it is recommended to take 60 mg of medication per day. The maximum allowable daily dose is 80 mg.

Since the drug has a long half-life (2-3 days, and its active decay product - 7-9 days), its concentration inside the plasma continues to persist for several weeks.

In the elderly.

For a day it is allowed to take no more than 60 mg of Depres.

Persons with liver or kidney failure.

In the case of functional renal disorders of moderate type (glomerular filtration rates <15-50 ml / minute), as well as liver failure, it is necessary to reduce the dosage or take the medicine every other day. In particular, this applies to elderly people with concomitant pathologies that take in combination several medicines.


Signs of an overdose: vomiting, CNS activity excitement and nausea.

The medicine does not have an antidote. Symptomatic treatment is required to correct the disorders. It is necessary to take activated charcoal together with sorbitol or perform gastric lavage. Procedures for dialysis or forced diuresis do not help.

Interactions with other drugs

With a combination of Depression:

  • with drugs that have an overwhelming effect on the central nervous system, and in addition to ethyl alcohol, there may be significant potentiation of the above effects, and with it an increase in the likelihood of seizures;
  • with drugs that have a high level of synthesis with protein (especially with digitoxin or anticoagulants), plasma values of free drugs can increase and the risk of negative reactions may increase;
  • with lithium drugs, as well as phenytoin - may increase the value of these drugs, as well as a toxic effect;
  • with the substance tryptophan - can increase motor anxiety, and in addition to increase the severity of disorders in the gastrointestinal tract;
  • with other antidepressants - their plasma values increase;
  • with benzodiazepines - in some patients, the half-life of diazepam may be prolonged;
  • with MAOI (among them moclobemide or selegiline) - because of the increase in serotonin levels, as well as the inhibition of its re-uptake, there is a significant increase in the volume of serotonin within the synapse. As a result, serotonin intoxication develops, against which there is rigidity of muscles, hyperthermia, and in addition myoclonus with signs of imbalance in the physiological as well as mental state of the person (with possible fatal outcome).

Storage conditions

It is required to keep the depress in a dark, dry place inaccessible to young children. Temperature values are a maximum of 25 ° C.

Shelf life

Depres is allowed to use in the period of 2 years from the date of release of the medicinal product.

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To simplify the perception of information, this instruction for use of the drug "Deprez" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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