The combination of St. John's wort medicines with MAOI or the use of the latter directly after the use of Deprivitis can lead to the potentiation of side effects of drugs.
Simultaneous use with other antidepressants (among them citalopram with sertraline, fluoxetine with fluvoxamine, and paroxetine) and derivatives of tryptane (among them naratriptan with sumatriptan and zolmitriptan), can also potentiate side effects (eg, vomiting, a feeling of fear or excitement, and besides this nausea).
In addition to the methods described above, the drug is able to interact with other drugs that are metabolized by enzymes of the hemoprotein system P450. The effect on enzymes can be observed after the use of drugs containing St. John's wort extract. Because of this, Deprivit can interact with other medicines in the period of 2 weeks after its cancellation.
The medicines of St. John's wort can potentiate the activity of many enzymes that are participants in the metabolism of other drugs. As a result of such reactions, a decrease in plasma values and the weakening of the medicinal properties of individual preparations are possible.
The drug weakens the properties of anticoagulants of an indirect type of action (this includes fenprocumone with warfarin), and in addition digoxin with nortriptyline, cyclosporine and theophylline with amitriptyline and indinavir. Therefore, they can be used in combination only with the permission of the doctor (in this case, it is necessary to monitor the indices of PTV and blood at the initial and final stage of therapy).
Simultaneous reception of Deprivitis with oral contraceptives of hormonal type can cause a weakening of their effectiveness, as well as the occurrence of bleeding in periods between menstruations.
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