Delagil

Delagil is an immunosuppressant, is included in the category of antimalarial and antiprotozoal drugs.

[1], [2], [3]

Indications Delagil

It is indicated for the prophylaxis and treatment of malaria, and also for the elimination of the hepatic abscess caused by amoeba, amoebiasis (extraintestinal form), chronic or subacute stage of Liebman-Sachs disease and in addition to porphyria, rheumatoid arthritis, systemic scleroderma and photodermatitis.

Release form

It is produced in tablet form - on one blister 10 tablets. In one package 3 blister plates.

Pharmacodynamics

The drug is included in the category of antimalarial and amebicidal drugs. Is a derivative of 4-aminoquinoline. Delagil is used in the standard treatment of rheumatoid arthritis.

The drug slows the process of DNA synthesis, affecting the activity of enzymes, as well as the speed of the immunological changes that occur in the body. The antimalarial effect is based on the rapid destruction of a variety of plasmodial species (asexual forms) - such as Plasmodium malariae, Plasmodium falsiparum, and Plasmodium vivax.

Due to the slowing down of nucleic acid compounds, the drug acquires immunosuppressive and non-specific anti-inflammatory properties.

[4], [5], [6]

Pharmacokinetics

Chloroquine is rapidly absorbed from the digestive tract. The peak of the plasma concentration of the active substance reaches 2-6 hours later.

Synthesis with plasma protein is 55%. Chloroquine is cumulated in the spleen, kidneys with liver, and also lungs. It is well synthesized with thrombotic and granulocytes, and besides it passes through the placenta and GEB. It is allocated together with milk. A small part of the substance (approximately 25%) undergoes a metabolism in the liver.

The half-life is 30-60 days. Approximately 70% of the substance is excreted unchanged. Acid reaction of urine accelerates the process of drug excretion.

[7],

Dosing and administration

Delagil is consumed after ingestion, orally.

To eliminate malaria, a dosage of 2-2.75 g is required for the whole treatment course: for the first day 1 g, after 11-12 hours, take another 0.5 g, then on the 2nd and 3rd days for 0, 5-0.75 grams once. Adults can take no more than 1.5 grams of medicine per time. For children 6-10 years of age, the dosage on the first day is 0.25 g, followed by 0.125 g on the 2nd and 3rd days of therapy. For children of 10-15 years of age, the dosage on the first day is 0.5 g, after which the 2 nd and 3 rd are 0.25 g.

To prevent the development of malarial infection - 2 times / week in the amount of 0.5 g, after which 1 time / week for 0.5 g.

For the treatment of rheumatoid arthritis - for 6-8 days drink 0.5 g per day (in 2 doses). After that, for 12 months every day to drink 0.25 grams of medication.

In the treatment of amoebiasis: a dosage of 500 mg three times a day for one week, then three times a day for 250 mg for a further week. Then take 750 mg twice a week for 2-6 months.

To eliminate Liebman-Sachs disease, you need to drink 250-500 mg every day.

For the treatment of photodermatitis: for 7 days every day for 250 mg, after which once a week to drink 500-750 mg.

Use Delagil during pregnancy

Delagil can not be given to pregnant women.

Contraindications

Among the contraindications of the drug:

• kidney or liver failure;
• severe forms of irregular heartbeat rhythm;
• Suppression of the hematopoietic process inside the bone marrow;
• hematoporphyrinuria, or neutropenia;
• intolerance of the components of the drug;
• children under 6 years of age.

Side effects Delagil

The result of taking the medication is sometimes such side reactions:

• organs of the National Assembly: headaches and dizziness, the appearance of seizures, the development of psychomotor agitation, psychosis or insomnia, and besides this neuropathy;
• ODA organs: development of myopathies;
• sensory organs: the appearance of noise in the ears, the disorder of accommodation or hearing, the deterioration of visual perception, the development of retinopathy, the opacity of the eye cornea, and in addition the reversible form of keratopathy;
• organs of the digestive system: the emergence of nausea with vomiting, and in addition diarrhea, abdominal pain (spastic type), the development of anorexia, weight loss, as well as hepatotoxicity;
• organs of the cardiovascular system: cardiomyopathy may develop or the blood pressure level may drop;
• Skin reactions: rashes and itching, dermatitis, skin pigmentation, photosensitivity, and alopecia.

[8]

Overdose

As a result of an overdose of the drug, vomiting occurs, and in addition to convulsions, collapse begins, suppression of the respiratory process occurs, as well as loss of consciousness.

To eliminate the violations should be done by gastric lavage and drink adsorbents. If the intoxication was severe, you can use plasmacytophore as well as peritoneal dialysis.

Interactions with other drugs

Simultaneous reception with other antimalarial drugs enhances the properties of Delagil.

It is forbidden to combine with cytostatic agents, levamisole, as well as gold medications and penicillamine, because such a combination can enhance the side effects of drugs.

Simultaneous use with MAO inhibitors enhances the toxic properties of Delagil.

The long-term combined use of Delagil and cardiac glycosides can cause glycoside poisoning.

The poisoning effect of the drug on the liver is enhanced when combined with ethanol.

Combination with GCS raises the possibility of the occurrence of myopathies, and besides this cardiomyopathy.

Simultaneous use with antacid drugs disrupts the absorption of chloroquine.

As a result of the combination with cimetidine, plasma indices of chloroquine can increase.

[9], [10]

Storage conditions

Keep the medicine should be in the standard for medicines conditions - a dry, dark place. The temperature is not more than 25 ° C.

Shelf life

Delagil is usable for 5 years from the date of production of drugs.