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Dekapeptil
Last reviewed: 23.04.2024
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Decapeptil is a synthetic hormone preparation, a natural GnRH (hormone-releasing-gonadotropin) agonist. It is one of the effective drugs that is widely and successfully used in medicine for the treatment of many diseases.
The drug is released only if there is a prescription certified with a personal medical seal. Independent use of the drug is excluded.
[1],
Indications Dekapeptil
The preparation is used:
- for the treatment of endometriosis;
- in the complex scheme of infertility treatment, while carrying out the protocols of the newest reproductive technologies;
- with fibromyoma (leiomyomia);
- as one of the links of symptomatic therapy in the progression of hormone-dependent cancer of the prostate gland.
[2]
Release form
Decapeptil is available in the form of an injection solution: it has no color and aroma, a clear liquid, represented by the following components:
- active ingredient - tryptorelin acetate, 105 mcg / 1 ml;
- additional components - sodium chloride, ethanoic acid, sterile water.
The drug is released in cardboard packages containing cell elements with syringe-ampoules and needles to them in an amount of 7 pieces. In each syringe-ampoule contains 1 ml of Decapeptil.
Pharmacodynamics
Gonadotropin-releasing hormone agonist has a similar effect with natural GnRH and is effective in reducing foci of endometriosis and in eliminating pain pelvic syndrome.
Immediately after the injection, Decapeptil provokes an increase in the level of FSH and LH in the plasma, which contributes to a short increase in the concentration of sex hormones.
Prolonged stimulation of the pituitary gland (with a stable level of triptorelin in the bloodstream) entails the inhibition of gonadotropic function, which in turn leads to a decrease in the concentration of sex hormones to the state of menopause or post-infection.
This symptomatology is reversible: after the drug is discontinued, the physiological secretion of hormones is restored.
Pharmacokinetics
In the initial 2-3 hours after intramuscular injection of Decapeptil, a peak concentration of the active substance in the blood is observed. Further, the level of tryptorelin significantly decreases throughout the day.
The half-life of the active component of the drug is determined to be 18.7 minutes (in this case, the half-life of the natural GnRH is determined to be 7.7 minutes). The rate of plasma clearance is slowed three-fold, compared to natural GnRH (503 ml per minute and 1766 ml per minute, respectively).
Slightly more than 3% of the active ingredient is unchanged in the form of kidneys.
The above indicators have official confirmation: the pharmacokinetics of decapeptil was observed in women with diagnosed endometriosis or fibromyoma, as well as in men with cancer of the prostate and in healthy men.
Dosing and administration
The drug is administered by subcutaneous injection.
If difficulty in conceiving is prescribed, injections of 0.0001 g of Decapeptil on the first day of menstruation, or at the beginning of the first phase of the ovarian cycle before the injection of the drug hCG (with a short version of the protocol), or from the first day of menstruation or at the beginning of the follicular phase for 3 days (with an ultrashort protocol).
In fibroids, endometrioid proliferation, prostate cancer, the first 7 days of therapy use 1 ml of 0.5 mg of Decapeptil once a day at the same time. On the eighth day of therapy, 0.1 mg of medication is administered every day. The duration of the course of therapy is determined by the doctor individually.
If a long period of treatment is planned, it is recommended to prescribe a similar drug Decapeptil-Depot, which has a prolonged effect.
Use Dekapeptil during pregnancy
The use of decapeptil during pregnancy and in the period of breastfeeding is categorically contraindicated. Moreover, even before the start of treatment, it is necessary to make sure that there is no pregnancy, and to provide reliable barrier contraceptive for the whole course of Decapeptil therapy.
Contraindications
Decapeptil can not be prescribed:
- with a diagnosed pregnancy or with a suspicion of it;
- during breastfeeding;
- with signs of obvious or latent osteoporosis;
- with hormone-independent carcinoma of the prostate;
- after surgical castration in the anamnesis;
- with a tendency to allergic reactions to tryptorelin.
With caution appoint a drug with significant polycystosis of the appendages.
[12],
Side effects Dekapeptil
The use of decapeptil can cause side effects:
- lowering of sexual desire;
- numbness of limbs;
- mood instability, capriciousness, emotional differences;
- decreased vision;
- soreness with sexual contact;
- migraine;
- osteoarticular pain;
- bouts of nausea;
- rolling sensations of heat (hot flashes);
- skin peeling;
- lymphadenopathy;
- myasthenia gravis, muscle pain;
- difficulties with urination;
- hemorrhage;
- appetite disorders, changes in body weight;
- increased body temperature;
- accumulation of fluid in the limbs;
- dryness of the vulva and vagina;
- increased sweating;
- demineralization of bones and joints;
- sleep disorders;
- thrombophlebitis;
- increase in cholesterol in the blood.
Side effects of Decapeptil disappear after some time after drug discontinuation.
Overdose
Officially recorded facts of an overdose of Decapeptil was not noted. When an overdose is suspected, symptomatic therapy is necessary.
Storage conditions
Storage Dekapeptil is carried out at t ° from +2 to + 8 ° C. Do not store the product outside the original packaging.
If the syringe-ampoules are damaged or the expiry date expires, the drug should be discarded.
Shelf life
Shelf life Dekapeptil - up to 3 years (production date must be indicated on the package).
[23]
Attention!
To simplify the perception of information, this instruction for use of the drug "Dekapeptil" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.