Deep Hit

Deep Hit is a medical product that is commonly used to relieve pain and reduce inflammation from muscle strains, bruises, rheumatic pain and other muscle and joint conditions. It contains several active ingredients:

1. Methyl salicylate is an anti-pain substance that has properties similar to aspirin. It relieves pain and reduces inflammation.
2. Racemic menthol is a menthol alcohol that produces a cooling sensation and may help reduce feelings of pain and itching.
3. Eucalyptus oil - known for its anti-inflammatory and antiseptic properties. It can help relieve pain and reduce inflammation.
4. Turpentine oil is a liquid obtained from coniferous trees such as pine. It has a warming effect and can help soothe pain and reduce inflammation.

These components combine to provide relief from pain and inflammatory symptoms that often accompany muscle and joint problems.

Indications Deep Hit

1. Muscle and joint pain: This drug may help relieve pain caused by muscle strains, bruises, rheumatic pain, and other similar conditions.
2. Inflammation: Thanks to its anti-inflammatory properties, Deep Hit can reduce inflammation associated with various muscle and joint problems.
3. Sports Injury Pain: This medication may be helpful in relieving pain and reducing inflammation from sports injuries, such as sprains, sprains, and bruises.
4. Myalgia: Deep Hit can be used to relieve pain from muscle pain, such as myalgia caused by exercise or tension.
5. Arthritis and other joint diseases: Since Deep Heat has anti-pain and anti-inflammatory properties, it may be useful in relieving pain and discomfort from various joint diseases such as arthritis.

Release form

The ointment or gel form ensures easy application and absorption of the drug through the skin into the area of pain or inflammation.

Pharmacodynamics

1. Methyl salicylate:

   • It is a salicylate that exhibits analgesic and anti-inflammatory properties.
   • The mechanism of action of methyl salicylate is its ability to suppress the production of prostaglandins, substances that play a key role in pain and inflammation.

2. Menthol:

   • Menthol has a cooling and anesthetic effect that helps reduce sensitivity to pain.
   • It can also stimulate receptors in the skin, causing a sensation of cold, which can alleviate the sensation of pain.

3. Eucalyptus oil:

   • Eucalyptus oil has antiseptic and anti-inflammatory properties.
   • It can help soothe inflammation and make it easier to breathe during nasal congestion.

4. Turpentine oil:

   • Terpentine oil also has anti-inflammatory properties and can help reduce inflammation in muscles and joints.

Pharmacokinetics

1. Methyl salicylate:

   • Absorption: Methyl salicylate is generally well absorbed through the skin when applied topically.
   • Distribution: After absorption, methyl salicylate is distributed into tissues and exerts local analgesic and anti-inflammatory effects.
   • Metabolism: Methyl salicylate can be metabolized in the liver to salicylic acid.
   • Excretion: Methyl salicylate and its metabolites are excreted from the body, primarily through the kidneys.

2. Menthol Racemic:

   • Absorption: Menthol is also well absorbed through the skin.
   • Distribution: It is distributed into tissues and has a local cooling effect.
   • Metabolism and Excretion: Menthol can be metabolized in the liver and excreted from the body, mainly via the kidneys.

3. Eucalyptus Oil and Turpentine Oil:

   • Absorption and Distribution: These oils can also be absorbed through the skin and have a local irritant and anti-inflammatory effect.
   • Metabolism and Excretion: Their metabolism and excretion may be affected by the metabolism and excretion of other components of the drug.

4. Interactions: Due to topical and often short-term use, interactions with other drugs are generally unlikely. However, you should avoid using other topical medications on the same area of skin without consulting your doctor.

5. Side effects: Local side effects may include skin irritation, redness, and rarely allergic reactions.

Dosing and administration

1. Method of application:

   • Deep Hit ointment or gel is applied in a thin layer to the skin in the area of pain.
   • The drug should be applied with light massaging movements until completely absorbed.
   • It is recommended to avoid application to irritated or damaged skin, and also avoid contact with eyes and mucous membranes.

2. Dosage:

   • The dosage depends on the intensity of the pain, the size of the area that needs to be treated, and the individual characteristics of the patient.
   • Applying a small amount of ointment or gel to the skin is usually sufficient to cover the area of pain.
   • Reapplication may be necessary after a few hours depending on individual needs.

3. Use frequency:

   • Deep Hit ointment or gel can be used up to several times a day, depending on how often symptoms occur and how severe they are.

Use Deep Hit during pregnancy

Using products containing methyl salicylate (including Deep Hit), menthol, eucalyptus oil and turpentine oil during pregnancy may be associated with some risks. Methyl salicylate and other components in these mixtures can penetrate the skin, potentially leading to toxic effects, especially if used in large quantities or over large areas of the body.

Special restrictions and risks include:

• Methyl salicylate: This ingredient may cause systemic reactions similar to aspirin, which is a salicylate. Use of aspirin during pregnancy, especially in the third trimester, may result in prolonged gestational age, prolonged labor, and other health risks for the mother and fetus (Collins & Turner, 1981).
• Menthol: Although menthol is commonly used as a topical analgesic, its use in large quantities may promote excessive absorption through the skin, potentially leading to side effects.
• Eucalyptus and turpentine oils: These oils can cause skin irritation and have the potential for allergic reactions, which can also affect pregnancy.

In general, due to the possible risk of negative effects on pregnancy and the fetus, the use of Deep Hit and other products containing these ingredients should be limited or avoided.

Contraindications

1. Hypersensitivity: People with a known hypersensitivity to methyl salicylate, menthol, eucalyptus oil, oil of turpentine, or any of the ingredients of the drug should not use Deep Hit.
2. Asthma: The use of Deep Hit may be contraindicated in patients with asthma, as some of its components may cause an allergic reaction or exacerbation of symptoms of the disease.
3. Damaged or irritated skin: Using Deep Hit on damaged or irritated skin may increase irritation and cause burns or allergic reactions.
4. Children: For children under 2 years of age, the use of menthol and eucalyptus oil may be contraindicated due to the risk of developing serious complications such as obstructive bronchitis.
5. Pregnancy and breastfeeding: Data on the safety of Deep Hit during pregnancy and breastfeeding are limited, so its use during this period should only be done on the advice of a physician.

Side effects Deep Hit

1. Allergic Reactions: Some people may be allergic to one or more of the ingredients in Deep Hit. This may manifest itself as a skin rash, itching, hives, or even more serious allergic reactions.
2. Skin Irritation: Applying Deep Hit to the skin may cause irritation in some people, especially if they have sensitive skin or wounds.
3. Redness and Burns: The cooling and heating effects of menthol and turpentine oil can cause skin redness and even burns, especially if the drug is used in large quantities or on damaged skin.
4. Hypothermia or overheating: Using Deep Hit can lead to excessive cooling or heating of the skin, depending on the sensitivity of the skin and the individual reaction to the drug.
5. Respiratory Problems: Inhaling vapors from eucalyptus oil and turpentine oil may cause respiratory irritation in some people, which may lead to coughing or difficulty breathing.

Overdose

1. Methyl salicylate poisoning:

   • Methyl salicylate contained in Deep Heat is a derivative of acylated salicylic aldehyde and can cause serious undesirable effects in overdose, such as nausea, vomiting, burning in the stomach, abdominal pain, dizziness, a sharp decrease in blood pressure, hypertension, central nervous system stimulation, as well as extremely dangerous consequences such as metabolic acidosis, seizures, arrhythmias and respiratory arrest.

2. Toxic effects of menthol:

   • Menthol can cause irritation of the skin and mucous membranes, and in case of overdose, serious respiratory problems, fainting, arrhythmias, extreme lethargy and coma.

3. Risks of eucalyptus and turpentine oils:

   • Overdose of eucalyptus and turpentine oils can lead to severe allergic reactions, respiratory problems, hypertension, heart rhythm disturbances, as well as toxic effects on the central nervous system and kidneys.

4. Other complications:

   • Overdose may also cause skin irritation, burns, allergic reactions and other serious complications.

Interactions with other drugs

1. Local preparations: When using other external preparations on the same area of skin simultaneously with Deep Hit, an increase in local irritation or allergic reactions may occur.
2. System NSAIDs (nonsteroidal anti-inflammatory drugs): When used in parallel with methyl salicylate from Deep Hit, systemic side effects such as gastric ulcers and bleeding may be increased.
3. Anticoagulants: Methyl salicylate may increase the risk of bleeding when used in parallel with anticoagulants such as warfarin.
4. Dermal Absorption Enhancers: Some medications may enhance the absorption of topical Deep Heat components through the skin, which may result in increased blood concentrations and increased systemic side effects.
5. Menthol and eucalyptus oil: These components may affect the mucous membrane of the respiratory tract. When used in parallel with other drugs for the treatment of respiratory diseases, care should be taken to avoid unwanted effects.

Storage conditions

1. Temperature: The drug should be stored at temperatures up to 25°C. Deep Hit is generally stable at room temperature, but avoid storing in areas with extreme temperatures or exposure to direct sunlight.
2. Packaging: Before use, make sure that the packaging of the drug is intact. If the packaging is damaged or expired, the drug should be disposed of in accordance with local rules and regulations.
3. Children's accessibility: Keep Deep Hit out of the reach of children to prevent accidental use.
4. Before use: Before using the drug, carefully read the instructions for use to ensure that the drug is used correctly.