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De-nol in gastritis: the scheme of proper treatment

, medical expert
Last reviewed: 03.07.2025
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Gastritis is perhaps the most common disease of the digestive tract. It is caused by the development of an inflammatory process, which, in turn, occurs when a specific bacterium Helicobacter pylori gets on the mucous membrane. To cure gastritis, the use of anti-inflammatory drugs alone is not enough: it is necessary to protect the internal tissues of the stomach, stabilize acidity and enzymatic activity and neutralize the pathogenic bacteria. The drug De-nol for gastritis is prescribed precisely for these purposes: based on bismuth, this medication successfully regulates the supply of hydrochloric acid, has a detrimental effect on Helicobacter, covers the gastric mucosa with a softening film to protect against damaging factors. In addition, De-nol stimulates the restoration of stomach cells, heals minor tissue defects, accelerating recovery.

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Indications De-nol

De-nol is included in the treatment regimen not only for gastritis, but also for other pathologies of the digestive system:

  • peptic ulcer (stomach and duodenum);
  • chronic gastroduodenitis in the acute period;
  • irritable bowel syndrome with frequent loose stools;
  • functional dyspepsia that is not associated with organ pathologies of the digestive system.

Gastritis is the main indication for prescribing the drug De-nol.

  • De-nol for erosive gastritis is used in combination with medications that suppress acid production: these can be proton pump inhibitors (Omeprazole) or H2 - blockers. Complex treatment allows for the elimination of dyspepsia in a short period of time, stopping the signs of nausea and vomiting. In acute stress gastritis, De-nol promotes the healing of bleeding erosions.
  • De-nol for atrophic gastritis is also part of the main treatment: it is prescribed together with Metronidazole, proton pump inhibitors. Therapy is carried out during the active phase of the inflammatory atrophic process. During the period of calm of the disease, treatment is redirected to replenish the deficiency of digestive enzymes.
  • De-nol for gastritis with increased acidity helps to improve the protection of the gastric mucosa, normalize enzyme activity, and neutralize the activity of Helicobacter. Additionally, dopamine antagonists and prokinetic agents are prescribed. Most often, the treatment regimen for this type of gastritis includes taking Motilium (Reglan), De-nol, Festal, Maalox, as well as a special diet to normalize acidity in the stomach.
  • De-nol is prescribed for gastritis with low acidity as an antibacterial and enveloping agent. The main role in this case is played by replacement therapy: pepcidil, gastric juice, acedin-pepsin are used. To activate the function of the stomach, it is appropriate to prescribe Limontar, Etimizole, Proserin, calcium gluconate.
  • De-nol is prescribed for chronic gastritis in the acute stage of the disease: this drug forms a protective layer on the mucous tissues, providing many hours of protection of the organ. In addition, De-nol has high bactericidal properties with respect to Helicobacter pylori, so the treatment is carried out in several directions at once: the bacterial cause of gastritis is eliminated, the stomach tissues are protected and restored. De-nol is taken for 1-2 months during an exacerbation of gastritis, and bismuth preparations play a particularly important role at this stage. Chronic gastritis can be cured if you are patient and follow all the doctor's instructions exactly.
  • De-nol is not used as the main drug for reflux gastritis, but only as an addition to the main treatment. The basic drug is proton pump inhibitors (Pantoprazole, Omeprazole). It will also be necessary to improve the functioning of the hepatobiliary system (Ursochol, Urosan, etc. are prescribed for this).
  • De-nol for superficial gastritis (or catarrhal) is mainly used to destroy Helicobacter pylori. Additionally, agents are prescribed to normalize acidity in the stomach, general tonics and, if necessary, enzyme preparations.
  • De-nol may be useful for hyperplastic gastritis if pathogens such as Helicobacter pylori were detected during diagnostics. The treatment regimen is determined based on the presence of these bacteria. In case of extensive growths, surgical treatment may be prescribed, and De-nol is also prescribed in preparation for it.

Release form

The basic ingredient of De-nol, which is used for gastritis, is bismuth tripotassium dicitrate. One tablet contains 304.6 mg of this ingredient: its properties form the basis of the therapeutic effect of the drug. By the way, here is a list of these properties:

  • enveloping;
  • anti-inflammatory;
  • astringent;
  • restorative;
  • antibacterial against Helicobacter pylori.

De-nol looks like ordinary white tablets, convex on both sides, with a barely noticeable beige tint. On one side of each tablet there is an embossing gbr 152. On the opposite side there is a square with rounded corners.

The tablets are sealed in blister strips, eight tablets in each blister. Cardboard packaging may contain seven or fourteen strips.

Other possible names for De-nol

As we have already said, De-nol is represented by the active ingredient bismuth tripotassium dicitrate (bismuth subcitrate). This drug with a similar composition is not the only one of its kind: there are quite a few similar products with the same composition, but produced by other pharmaceutical companies. For example, De-nol for gastritis can be easily replaced by such drugs as Vis-Nol, Gastro-Norm, Ulcavis, Ventrisol, Escape, Novobismol, etc.

Vis-Nol

One Vis-Nol gelatin capsule contains 499.8 mg of colloidal bismuth subcitrate (conversion to Bi 2 O 2 120 mg).

Gastro-Norm

One tablet contains 320 mg of bismuth subcitrate, as well as a number of additional substances.

Ulkavis

The tablet contains 120 mg of bismuth oxide as tripotassium dicitrate.

Ventrisol

One tablet contains 0.12 g of bismuth tripotassium dicitrate.

Escape

One tablet contains 300 mg of bismuth tripotassium dicitrate (converted to bismuth oxide - 120 mg).

Novobismol

The tablet contains 304.6 mg of bismuth tripotassium dicitrate (converted to bismuth oxide - 120 mg).

The medications listed in the table are complete analogues of De-nol, which can easily replace this drug for gastritis. Drugs with a similar effect, but with a different active ingredient in the composition are presented in the following table:

Pariet

Pariet contains the active ingredient rabeprazole sodium.

Ampylop

Ampilop contains an extract of Ampilopsis cantoniensis, refers to antiulcer agents. Approved for use from the age of 12. The standard dosage for gastritis is 2 capsules three times a day after meals.

Venter

A drug based on sucralfate, used in treatment regimens for gastritis, peptic ulcer, gastroesophagitis. Venter is taken one tablet 4 times a day between meals.

Omez

A complete analogue of Omeprazole, used to treat erosive and atrophic gastritis, peptic ulcers and reflux esophagitis. Can be used in children from one year of age.

For adults, the standard dosage is 20 mg of the drug daily, in one dose. The average treatment period is two weeks.

Omeprazole

Domestic drug, proton pump inhibitor. Complete analogue of Omez.

Nolpaza

Pantoprazole-based tablets (20 mg per tablet). Refers to proton pump inhibitors. Taken in the same way as Omeprazole.

What is preferable for gastritis - Omez or De-nol - is decided by the doctor. In fact, these two drugs belong to different drug groups and cannot replace each other. Sometimes they are included in the same treatment regimen, complementing the main antibacterial and anti-inflammatory effect. Such a comprehensive approach allows you to speed up the restoration of mucous tissues, and at the same time the functional capacity of the stomach.

Omeprazole or De-nol for gastritis are always prescribed in combination with other medications, as they have the same properties, but different mechanisms of action. And if Omez and Omeprazole are practically the same drugs, then De-nol is a completely different remedy. Therefore, you should not try to replace them on your own in a doctor's prescription.

Pharmacodynamics

De-nol is a representative of a group of antiulcer drugs with bactericidal properties (meaning bactericidal action aimed at Helicobacter pylori). In addition, De-nol for gastritis helps relieve the inflammatory reaction and creates an enveloping protection for the mucous tissues of the stomach.

The acidic gastric environment causes the precipitation of insoluble bismuth oxychloride and citrate, forming chelate compounds with the protein parent substance, which form a protective film on the damaged surface of the mucous tissue.

Along with increasing the production of prostaglandin E, De-nol stimulates mucus formation and hydrocarbonate secretion, activates cytoprotective reactions, strengthens the mucous membrane, making it less vulnerable to the influence of pepsin, enzymatic and salt components of bile acids, and hydrochloric acid.

De-nol increases the accumulation of the restorative agent, which is the epidermal growth factor, in the area of damage. During treatment with the drug, the action of pepsin and pepsinogen becomes less active.

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Pharmacokinetics

The active component of De-nol, represented by bismuth subcitrate, can be absorbed in the digestive system only in negligible quantities. Such quantities are not considered clinically significant, therefore the kinetic properties of the drug have not been studied in detail. It is known that less than 1% of the active ingredient is absorbed in the cavity of the stomach and small intestine, and the rest is excreted through the intestine. Such properties of the drug make it possible to take it for a long time, while the concentration content of bismuth in the plasma is maintained at 37.67 ± 25.06 μg / liter and is completely excreted on the 30th day after therapy.

The active ingredient is excreted primarily with feces. The tiny fraction of the drug that enters the systemic circulation is excreted from the bloodstream through the renal filtration system.

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Dosing and administration

The use of De-nol for gastritis involves the following treatment regimens:

  • Adult patients and children over fourteen years of age take one tablet of De-nol four times a day (including before bedtime), or two tablets twice a day, between meals.
  • Children over eight years of age and under fourteen years of age take one tablet twice a day, between meals.
  • Children from four years of age to eight years of age take the drug at a rate of 8 mg per kilogram of weight per day. The resulting amount of De-nol is divided into two doses. The daily dose for this age category should not exceed 2 tablets.

The course of De-nol for gastritis can last 1-2 months. After the end of treatment, it is prohibited to take any bismuth-containing drugs for the next 2 months. Specific information on how much De-nol to take for gastritis can be obtained from your doctor. To cancel the drug, diagnostic confirmation of the positive dynamics of restoration of the mucous membrane and functionality of the stomach is necessary.

What is De-nol prescribed with for gastritis? The so-called quadruple therapy consists of a combination of De-nol treatment and tetracycline (0.5 g 4 times a day), matronidazole (0.5 g three times a day) and omeprazole or another PPI (in the usual dose twice a day). Such a course usually lasts up to two weeks.

Before taking De-nol for gastritis, you need to make sure that female patients are not pregnant. It is also important to drink sufficient amounts of liquid throughout the entire period of therapy.

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Application for children

De-nol for gastritis in pediatrics can be used according to special schemes, with an exact calculation of the dosage. Specialists indicate that the prescription of the drug in certain dosages and a short course is absolutely safe for the child's body. True, there is a limitation: the child must be over 4 years old.

In many European countries, given the increasing resistance of Helicobacter pylori to such medications as Metronidazole and Clarithromycin, treatment with bismuth preparations is becoming increasingly common. Some specialists not only report the effectiveness of De-nol for gastritis, but also recommend its use as a first-line drug. The treatment is supplemented with agents for normalizing the intestinal biocenosis, such as prebiotics or probiotics.

Use De-nol during pregnancy

If gastritis makes itself known during pregnancy, then at the first signs it is necessary to contact a doctor who will conduct diagnostics and try to solve the problem using the safest medications.

Self-medication is unacceptable: bismuth preparations used for heartburn and gastritis are contraindicated for use by pregnant women, as they can negatively affect the nervous system of the unborn baby.

To avoid adverse effects, before taking De-nol for gastritis, you should first discuss treatment options with your doctor. If De-nol can be replaced with any other, safer means, then it is better to make this replacement and not risk further development of the fetus.

A contraindication to the treatment of gastritis with De-nol, in addition to pregnancy, is also the entire period of breastfeeding.

Contraindications

The doctor will not prescribe De-nol for gastritis if the patient has certain contraindications:

  • hypersensitivity of the body to bismuth-containing drugs;
  • severe kidney and/or liver damage;
  • the entire period of bearing and breastfeeding the baby.

De-nol is not used to treat gastritis in children under four years of age.

In all remaining cases, the drug can be taken after consultation with the attending physician.

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Side effects De-nol

It should be remembered that, despite the predominantly positive properties of De-nol for gastritis, this drug still belongs to the salts of heavy metals. Therefore, De-nol is dangerous due to the appearance of many side effects. Thus, against the background of gastritis treatment, dyspeptic reactions may develop in the form of nausea, vomiting, loss of appetite, a "metallic" taste in the mouth, bloating, constipation. No less often, pain appears in the projection area of the stomach or in the abdomen. In addition, other painful conditions may occur: gingivitis, joint pain, pseudomembranous colitis.

From the immune side, the development of allergic reactions is often noted.

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Overdose

With an increase in the concentration of bismuth in the plasma, symptoms of bismuth encephalopathy may appear:

  • headache;
  • dizziness;
  • hyperexcitability, or, conversely, apathy;
  • sleep disorders;
  • photophobia;
  • depressive states.

Such complications occur when the bismuth content in the bloodstream increases to more than 1500 mcg/liter.

To avoid overdose, it is not recommended to take De-nol for gastritis for more than 6-8 weeks in a row (provided that an adequate dose of the drug is taken).

If signs of overdose are detected, the victim's stomach is washed, activated carbon and osmotic laxatives are given. In case of persistent deterioration of kidney function, hemodialysis is indicated.

Interactions with other drugs

Like any other medication used for gastritis, De-nol has a number of drug interactions that must be taken into account throughout the entire treatment period. Thirty minutes before taking De-nol, as well as for half an hour after taking it, you must not take any other medications, food or drinks.

De-nol may reduce the absorption of tetracyclines and other antibiotics.

The combined use of De-nol with other bismuth-containing drugs (we are talking about Vikalin, Vikair, etc.) can provoke an overdose due to the increased concentration of bismuth in the bloodstream.

Any antacids, which are often prescribed for gastritis, are also taken no later than half an hour before taking De-nol, or half an hour after taking it. For example, this principle also applies to such a combination of drugs as De-nol and phosphalugel: the interval between taking these two drugs should be at least thirty minutes.

Omez and De-nol are prescribed simultaneously for gastritis if there is an erosive form of the disease. However, the word "simultaneously" does not mean that the drugs should be taken at the same time. De-nol is taken two or four times a day, and Omez - once a day. The interval between taking the two medications should be at least thirty minutes.

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Storage conditions

The instructions suggest storing De-nol in dry places, away from direct sunlight. It is preferable that the storage location be darkened and the ambient temperature not exceed +25°.

The storage area for the medication should be secured from access by children and mentally ill people.

It is unacceptable to store the medication in the refrigerator, as this may negatively affect the medicinal properties of De-nol.

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Shelf life

De-nol can be used for the treatment of gastritis for 4 years (the period is calculated from the production date, which is indicated on the packaging).

Reviews after using De-nol for gastritis

De-nol is often prescribed specifically for the treatment of gastritis, which is explained by the pronounced anti-inflammatory, antibacterial, enveloping properties of the drug. The drug is produced in the form of tablets: this is convenient, since De-nol has to be taken several times a day. You can take the tablets with you and take them when needed.

About 80% of patients note that De-nol is really effective for gastritis. But only if the full course of therapy is completed. For example, if the doctor prescribed taking the medication for 4 weeks, and the patient felt relief after a week, this is not a reason to stop the treatment: the course must be completed and the drug must not be canceled on your own. To enhance the effect, De-nol is taken separately from other medications and food products. During the entire course of treatment, it is recommended to exclude alcohol, strong coffee and tea, carbonated drinks from the diet.

Many patients warn that while taking De-nol for gastritis, the surface of the tongue may darken, and feces may become dark. Such symptoms are transient and are explained by the presence of bismuth in the drug. At the end of treatment, the condition normalizes.

Attention!

To simplify the perception of information, this instruction for use of the drug "De-nol in gastritis: the scheme of proper treatment" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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