Dalacin C

Dalacin C belongs to the lincosamide group of antimicrobial drugs. The main active ingredient of the drug is clindamycin, which destroys some types of bacteria and is also resistant to the action of gastric juice.

Dalacin C requires regular monitoring of liver and kidney function when used for a long time. The dosage of the drug is selected with caution if the patient has had gastrointestinal diseases in the past (especially inflammation of the intestinal mucosa).

Dalacin C can provoke intestinal inflammation both during treatment and several weeks after the end of the course of treatment (especially in the elderly and in debilitated patients).

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Indications Dalacin C

Dalacin C is prescribed for infectious and inflammatory processes of the ENT organs (pharyngitis, laryngitis, otitis, scarlet fever, etc.), respiratory organs (pneumonia, bronchitis, purulent pneumonia, etc.), infections of the skin and soft tissues (inflammation of the hair follicles, purulent wounds, erysipelas, etc.), infectious diseases of the bones or joints (osteomyelitis, septic arthritis), infections of the female genital organs (inflammation of the uterine mucosa, pus in the fallopian tubes, inflammation of the ovaries, etc.), infections of the abdominal cavity (purulent inflammation of the abdominal organs), infections of the oral cavity.

The medication is also prescribed for preventive purposes as part of complex therapy after intestinal perforation.

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Release form

Dalacin C is available in the form of capsules for oral administration, granules for the preparation of syrup (for children) and a solution for injection.

Pharmacodynamics

The active ingredient of Dalacin C is clindamycin, which belongs to the group of lincosides.

The medication reduces the synthesis of pathogenic flora proteins, destroys some types of bacteria, and also prevents the reproduction of bacteria.

The drug is active against aerobic gram-positive cocci, anaerobic gram-negative microorganisms, gram-positive non-spore-forming bacteria. Chlamydia, clostridia,

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Pharmacokinetics

After intramuscular administration of Dalacin C, the maximum concentration of the drug is observed in the blood plasma after approximately two hours; after intravenous administration, after 15-20 minutes.

After taking the medication in capsule or syrup form, almost complete absorption in the gastrointestinal tract is observed. In adult patients, after taking capsules, the maximum concentration of clindamycin is observed in the blood serum approximately 40 minutes later.

After taking Dalacin C children's syrup, the maximum concentration of the active substance in the blood serum is observed after one hour.

The drug binds to proteins by 45-90%. The drug does not accumulate in the body.

Clindamycin penetrates well into many body fluids and tissues (except cerebrospinal fluid).

Dalacin C is 80% metabolized in the liver. The half-life is 2 to 4 hours. The drug is excreted mainly in feces (about 20% is excreted in urine).

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Dosing and administration

Dalacin C is prescribed by a doctor, who also determines the most effective dosage of the drug, taking into account the patient's condition, concomitant diseases, sensitivity of pathogenic flora, etc.

Usually, adult patients receive injections (up to 2.7 g per day) for complicated or severe infectious inflammatory processes. In some cases, the dosage can be increased to 4.8 g.

For mild forms of the inflammatory process, the drug is prescribed up to 1.8 g per day.

It is not recommended to administer more than 600 mg of the drug intramuscularly at one time.

The drug is prescribed orally up to 450 mg every six hours. The course of treatment in each case is determined by the attending physician (usually 10 days on average).

For children, the drug is prescribed in the form of a flavored syrup. Up to 25 mg per kg of body weight is usually prescribed per day. The daily dose should be divided into several doses (3-4).

Children weighing less than 10 kg receive 1/2 teaspoon three times a day. For children over 1 month, the drug is prescribed only in extreme cases (up to 40 mg / kg).

The solution prepared for injection may be stored for no more than 24 hours. The rate of intravenous administration should be from 10 to 60 minutes.

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Use Dalacin C during pregnancy

The safety of Dalacin C use by women during pregnancy has not been proven.

The medication is prescribed to pregnant women only in cases of extreme necessity (the dosage is determined by the attending physician).

Contraindications

Dalacin C is contraindicated in cases of hypersensitivity to clindamycin or lincomycin. The drug is also not used if the patient has had intestinal inflammation after antibacterial therapy in the past.

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Side effects Dalacin C

Dalacin C may cause the following side effects:
abdominal pain, nausea, upset stomach, rarely jaundice, intestinal inflammation, allergic rashes on the skin and mucous membranes, measles-like rash, anaphylactic shock, changes in blood composition, rarely respiratory and cardiac problems (with rapid intravenous administration), increased blood pressure, inflammation of the vulva and vagina.

With intramuscular administration, various local reactions are possible (pain at the injection site, inflammation). In some cases, intravenous administration can provoke vascular inflammation and thrombus formation.

Quite rarely, there are disturbances of neuromuscular conduction, fungal and other infections.

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Overdose

There are no cases of Dalacin C overdose. In case of taking increased doses of the drug, symptomatic treatment is recommended (blood purification by hemodialysis is not effective).

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Interactions with other drugs

When Dalacin C is used in parallel with aminoglycoside drugs, a wider spectrum of antibacterial activity is observed.

The drug is not used simultaneously with erythromycin.

When Dalacin C is used simultaneously with muscle relaxants, the therapeutic effect of the latter increases.

Dalacin injections are not prescribed simultaneously with barbiturates, ampicillin, calcium gluconate, phenytoin, magnesium sulfate, or euphyllin.

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Storage conditions

The temperature at which Dalacin C must be stored must not exceed 25°C. The solution for injection preparation must not be frozen, as this may reduce the therapeutic effect.

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Shelf life

Dalacin C capsules are valid for five years from the date of manufacture, injection solution – two years.

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