Medical expert of the article
New publications
Preparations
Daivonex in psoriasis
Last reviewed: 23.04.2024
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Indications of the daivonex in psoriasis
Indications for the use of Daivonex in psoriasis is treatment of rashes of plaque psoriasis of mild and moderate degrees in the stationary and regressing stages of the disease.
Release form
The drug Daivonex with psoriasis has the following dosage forms: ointment (in tubes of 30 and 100 grams), cream (in tubes of 30 and 100 grams), solution (in p / e bottles of 60 ml).
[3]
Pharmacodynamics
The pharmacodynamics of all the medicinal forms of the Daivonex preparation for psoriasis is based on the inhibition of hypertrophic proliferation of keratinocytes and the regulation of their differentiation with the active substance calcipotriol (1,25-dihydroxy-D3), a bioactive synthetic form of vitamin D, which is a selective regulator of the human immune system and an inhibitor of the development of autoimmune diseases character.
Calcipotriol is a secosteroid substance having a molecular structure similar to that of sterols. It acts as a modulator of the nuclear receptors of vitamin D3 (VDR) cells of the cambial layer of the skin (stratum cambiale), which provides growth and regeneration of the epidermis; mononuclear leukocytes of peripheral blood (monocytes with phagocytic activity), as well as T cells-T-lymphocytes, which determine and regulate the body's immune response.
Binding to VDR cells of the epidermis, the active ingredient Daivonex blocks the protein catelicidin (LL-37), resulting in a decrease in the activity of dendrocytes (Langerhans cells) and mitosis of keratinocytes. A interaction of calcipotriol with vitamin D T-cell receptors leads to the normalization of the synthesis of thymus-stromal lymphopoietin (TSLP), which plays an important role in the maturation of inflammatory cytokines.
[4]
Pharmacokinetics
When applying Daivonex for psoriasis on the skin, systemic adsorption of calcipotriol does not exceed 4-5%.
1,25-dihydroxy-D3 is cleaved by liver enzymes to less active alpha- and beta-unsaturated ketone metabolites, which are slowly metabolized to calcitric acid. All products of the biotransformation of the drug that enters the bloodstream are excreted through the kidneys and intestines.
Dosing and administration
Ointment and Daivonex cream is applied to the psoriatic spots in a very thin layer (not rubbing into the skin) - once or twice a day. During the day you can use no more than 15 g of ointment or cream. The standard course of treatment is two months.
Diveonex in the form of a solution is used in case of damage to the scalp; one bottle (60 ml) should suffice for the treatment of the scalp during the week.
Neither ointment (or cream) nor solution is used to treat spots on the face skin.
Also, in the official instruction, the need for thorough hand washing after applying Davynonex is noted.
[9]
Use of the daivonex in psoriasis during pregnancy
Since the safety of this medication for pregnant women has not been studied, it is not recommended to use Daivonex in psoriasis during pregnancy.
Contraindications
Side effects of the daivonex in psoriasis
Among the side effects of Daivonex in psoriasis are increased dryness and itching of the skin, hypersensitivity to sunlight, changes in pigmentation, increased levels of calcium in the blood and urine. Perhaps the development of eczema or exacerbation of psoriasis.
[8]
Overdose
Most often, an overdose of this drug is associated with its more frequent use or with the application of large areas of skin. In case of dysregulation, signs of an increase in the level of calcium in the blood may be noted: muscle weakness, severe thirst, loss of appetite, nausea, vomiting, constipation, general retardation. In such cases, the use of Dayvonex ceases.
Storage conditions
Doctor's comments
Since the mid-1980s, numerous studies on the efficacy of ointments with calcipotriol in topical therapy for psoriasis have been carried out in domestic and foreign dermatology, and clinical trial reports have been published in specialized medical journals.
Reviews of dermatologists show: Daivonex in psoriasis - thanks to the action of calcipotriol - helps to reduce the severity of the rashes after a week of use. In two weeks, in almost 12% of cases, plaques become smaller and do not protrude above the surface of the skin, and the intensity of their peeling also decreases. And the result of using this drug within 30-40 days may be a long-term remission of psoriasis of mild and moderate severity.
Attention!
To simplify the perception of information, this instruction for use of the drug "Daivonex in psoriasis" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.