Daila

Planning pregnancy is an important aspect of the modern family and society as a whole, because the birth of a child is a serious and responsible event, and you need to be ready for it both morally and financially. Every year in our country, the number of abortions is increasing, especially among women who have previously lost their birth. This is a very dangerous trend, which can lead to a rapid increase in cases of secondary infertility after artificial abortions.

One of the newest contraceptive preparations Daila is a combined remedy effective for preventing unexpected pregnancy.

Indications Daila

Daila is an oral contraceptive. In addition to the effect of contraception, the drug is actively used in gynecology for menstrual irregularities, painful PMS, acne eruptions during adolescence, and also for suppressing lactation when the baby stops breastfeeding.

[1], [2], [3], [4], [5],

Release form

The preparation is produced in tablet form, each tablet is film-coated and contains 0.3 g of drospirenone and 0.002 g of ethinyl estradiol, as well as some excipients. The tablet has a diameter of about six mm, on one of the convex sides there is an inscription "G73".

Pharmacodynamics

The contraceptive effect of the drug is based on the effects of oppression of the ovulatory process and proliferation of the endometrium.

One of the active substances drospirenone, which is a progestogen, shows antimineralocorticoid and antiandrogenic abilities. These characteristics are pharmacologically identical to those of natural progesterone.

Among the capabilities of the second component of the drug ethinyl estradiol can be identified its property to reduce the risk of development of oncological diseases of the endometrium and ovaries. In addition, it produces a powerful anabolic effect, provokes oppression of the pituitary system, prevents the formation of a coronary form of atherosclerosis.

[6], [7]

Pharmacokinetics

When you take the medicine inside the product immediately and almost completely absorbed. The maximum content of active substance in the plasma reaches 38 ng / ml after 1.5 hours after the first administration of the drug. With constant intake, the maximum concentration reaches 60 ng / ml for 10 hours. The level of bioavailability can fluctuate between 60-80%. The amount of absorbed food and its composition do not affect the absorption of the drug.

Duration of partial excretion of the drug is about 30 hours.

Metabolites are excreted from the body with feces and urine; the period of partial excretion of metabolites is about 40 hours. Metabolites of the substance ethinyl estradiol are excreted approximately one day.

Insufficient function of the liver and urinary system lengthens the period of excretion of the drug.

[8], [9], [10], [11], [12]

Dosing and administration

The drug is used on the first day of menstrual bleeding. The reception is carried out every day at the same time, you can drink it with an ordinary amount of water or tea. The sequence of reception should be indicated on the package. After 21 days from the start of the procedure, a one-week break should be made, during which bleeding is detected by the type of menstruation. On the seventh day of the recess, the drug is resumed.

If the drug was accidentally missed, then the necessary pill should be drunk in the next 12 hours. The remaining tablets continue to be taken at the usual time.

If more time has passed than 12 hours, the contraceptive effect of the drug may be compromised.

If there is no bleeding within 7 days, you should be examined for possible pregnancy development.

If within 4 hours after taking the pill there was a urge to vomit, in the near future one should drink another pill instead of the previous one.

[22], [23], [24], [25], [26], [27]

Use Daila during pregnancy

The use of Dail in pregnancy is inexpedient and contraindicated.

If the pregnancy was detected during the use of the drug, then its reception should be immediately stopped.

There is no reliable data on the effect of contraceptive on the formation and growth of the embryo, and on the course of pregnancy itself. Known facts of the drug during the period of gestation do not allow specialists to draw any conclusions regarding the safety of its use.

All these findings, as well as the lack of expediency of taking the drug during pregnancy, deny the possibility of using contraceptive by pregnant women.

Contraindications

The most important contraindications to the use of oral contraceptives include:

• allergic reactions to any of the components of the drug;
• varicose veins, thrombophlebitis;
• disorders of cerebral circulation;
• vascular disorders, increased fragility of blood vessels, chronic hypertension syndrome;
• congenital predisposition to thrombosis, detection of antibodies to cardiolipin, lupus anticoagulant;
• chronic pancreatitis;
• severe liver diseases;
• severe form of kidney failure;
• presence or suspicion of the presence of malignant formations of the organs of the reproductive system;
• bleeding from the vagina of an unexplained genesis;
• confirmed or suspected pregnancy;
• neurological disorders, frequent and prolonged migraine attacks.

[13], [14], [15], [16], [17], [18]

Side effects Daila

Possible side effects of the drug:

• thrush, exacerbations of herpetic infection;
• allergic reaction;
• increased appetite, thirst;
• Depressive state, irritability, insomnia, decreased sexual desire;
• dizziness, impaired consciousness;
• visual dysfunction;
• arrhythmia, heart palpitations;
• increased blood pressure, migraine-like seizures;
• nausea, digestive system disorders;
• dermatitis, dry skin, swelling;
• muscle pains, convulsive conditions;
• cystitis;
• mastopathy, an increase and soreness of the mammary glands;
• increase in body weight.

[19], [20], [21]

Overdose

There are no reliable data on the overdose of Daila.

If you find symptoms such as nausea, redness of the face, slight bleeding from the vagina, you should see a doctor. There are no special drugs-antidotes of contraceptives.

[28]

Interactions with other drugs

The simultaneous use of Dail with rifampicin, griseofulvin, hypnotic drugs, St. John's wort can significantly increase the clearance of sex hormones.

Do not take the drug Daila women who use enzymatic agents.

Antibiotics of the penicillin and tetracycline group can reduce the content of ethinylestradiol in the blood.

Since the effect of the drug on other medicinal products has not been sufficiently studied, it is necessary to familiarize yourself with the annotation to the preparations before the simultaneous use of medications.

[29], [30]

Storage conditions

The preparation does not require special storage conditions; it is stored at room temperature, restricting children's access to medicines.

[31]

Shelf life

Shelf life of the packaged product is 2 years.