Cleavage Extract

Extract krasavki - a herbal remedy with spasmolytic properties. Consider the indications for its use, possible side effects and dosage.

The belladonna is a poisonous plant in the roots, leaves and berries which contain alkaloids of the tropane series. In medicine, it is used to make rectal suppositories. The plant extract has cholinolytic activity. Its active substances are alkaloids: atropine, scopolamine, hyoscyamine. They block m-cholinergic receptors and n-cholinergic receptors, reducing sensitivity to acetylcholine. As a result, impulses are carried out along the cholinergic nervous structures.

Rectal application promotes the interaction of active components with receptors in the smooth muscle layer of the rectum. It lowers the tone and stops the spasms of the rectum, minimizes the pain syndrome with anal fissures and hemorrhoids.

[1], [2], [3], [4], [5],

Indications of the extract of the belladonna

The main indication for the use of the bellane extract is cracks in the anus, hemorrhoids, intestinal colic. The drug can be used as a monotherapy, or in combination with other drugs.

[6]

Release form

Rectal suppositories are a form of release of the belladonna extract. Each candle contains 15 mg of the active ingredient. In one bundle there are two contour packs for 5 suppositories each.

[7], [8]

Pharmacodynamics

Extract krasavki has anti-inflammatory and antispasmodic properties. Pharmacodynamics of the drug is manifested holinoliticheskim action. Herbal remedy reduces the increased muscle tone of the abdominal cavity and effectively anesthetizes.

[9], [10], [11]

Pharmacokinetics

Since the drug is intended for rectal administration, its systemic reactions are very weak. Pharmacokinetics has not been studied. But the resorptive effect of alkaloids persists for 2-6 hours.

[12]

Dosing and administration

From the pathological condition and doctor's appointments depends on the method of application and dose of belladonna extract. Since the drug has the form of rectal suppositories, it is intended for administration to the rectum. The recommended dosage is 1 suppository 2-3 times a day. The maximum daily dose should not exceed 10 suppositories. Duration of treatment is 5-7 days. If necessary, the therapy can be extended, but after 2-3 days break.

[13],

Use of the extract of the belladonna during pregnancy

Hemorrhoids and anal fissures are problems that many future mothers face. Use of the belladonna extract during pregnancy and lactation is possible only for medical purposes. The drug is prescribed after a thorough assessment of the risks and the expected benefits of therapy.

Contraindications

Extract krasavki contraindicated for use with intolerance of its active components. The medicine is not used in such cases:

• Closed-angle glaucoma or suspected of it.
• Atony of the intestine and constipation.
• Ulcerative colitis in acute stage.
• Intestinal obstruction.
• Hypertrophy of the prostate.
• Severe atherosclerosis.
• Decompensation of cardiac activity.
• Pregnancy and lactation.
• Patients of childhood.

With special care the drug is prescribed for hypertension. It is not recommended for its long-term use in cholelithiasis, diaphragmatic hernia and nephrolithiasis.

Side effects of the extract of the belladonna

Incorrect use of the drug may cause side effects. Extract krasavki often provokes such reactions:

• Painful sensations in the digestive tract.
• Violations of the stool.
• Dryness of the oral mucosa.
• Short-term decrease in visual acuity.
• Headache.
• Decreased concentration of attention.
• Various allergic reactions and skin itching.
• Retention of urine.

With the development of the symptoms described above, it is necessary to stop using suppositories or to reduce their dosage. Required Required 

Overdose

The use of increased doses of belladonna can cause symptoms of an overdose. Most often, patients are confronted with reactions of psychomotor agitation, urinary retention and accommodation disorders.

Since there is no specific antidote, the withdrawal of the drug and further symptomatic therapy are indicated.

[14], [15]

Interactions with other drugs

It is not recommended to use the herbal remedy simultaneously with medicines with anticholinesterase and cholinomimetic activity. Any interactions with other drugs should be controlled by the attending physician. The belladonna reduces the therapeutic effect of morphine and caffeine.

When used with digitalis preparations, the risk of arrhythmia increases. Rectal suppositories enhance the pharmacological action of tricyclic antidepressants, barbiturates, beta-adrenomimetics and ganglion blockers.

[16]

Storage conditions

Since the drug has the form of suppositories, it is very important to observe the storage conditions. Suppositories must be individually packaged. The recommended storage temperature is 8 ° C, that is, it is best to keep the medication in the refrigerator. Non-compliance with this recommendation leads to deformation of the candles, which complicates the process of their introduction into the rectum. 

[17], [18], [19], [20]

Shelf life

Extract krasavki must be used within 24 months from the date of manufacture. Shelf life is indicated on the package with suppositories. Overdue medication is contraindicated. 

[21], [22]