Chymotrypsin

Chymotrypsin is a freeze-dried powder that is used in the manufacture of injection solutions. The medicine is used for ophthalmic procedures.

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Indications of the chymotrypsin

It is used in such cases:

• with fresh thrombosis in the central vein on the retina (extensive type) and opacity of the vitreous body due to inflammation or damage;
• with anterior uveitis, iritis, hemorrhages in the anterior part of the eye chamber, edema of the tissues around the eyes due to injuries or after operations, and also during the extraction of cataracts of the intracapsular type;
• with bronchitis or tracheitis, pulmonary inflammation or abscess and bronchial asthma, accompanied by hypersecretion;
• for the prevention of complications due to operations in the lungs;
• with bedsores, various wounds of a purulent type, as well as burns or thrombophlebitis;
• with otitis, sinus type sinusitis, osteomyelitis, tubootitis with a viscous effusion.

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Release form

It is produced in ampoules with a volume of 10 mg. Inside the pack - 5 or 10 ampoules of powder.

Chymotrypsin crystal

Chymotrypsin crystal is an enzyme drug used in the treatment of ulcers and wound surfaces.

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Pharmacodynamics

Proteolytic enzyme drug, which is extracted from pancreatic large horned animals. It helps to break down the bonds existing between the peptides within the protein molecules, and besides the bonds that formed with the participation of the remaining particles of aromatic amino acids - thereby it has an anti-inflammatory effect.

Lyses dead tissue, without affecting the areas with living cells. This can be achieved due to the presence of specific anti-enzymes in the medicine.

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Dosing and administration

Injection of a solution of Chymotrypsin is required in the / m way, in the amount of 5-10 mg per day (for children the dosage is 2.5 mg once a day). Before use, it is necessary to dissolve 10 mg of the drug in a solution of sodium chloride or novocaine (0.5-2%, take 2 ml of this solution), then deep into the buttock area (outer upper quadrant). For the course is about 6-15 injections.

In ophthalmology it is used for intravenous injections, for a special solution in the baths (0.2%) or in a solution (0.25%) for eye drops (3-4 times a day for 1-3 days) .

In pulmonology, the solution is administered intramuscularly - for a day in the amount of 5-10 mg, in the period of 10-12 days. To perform the inhalation, 10 mg of the substance inside the sodium chloride solution (3 ml) should be dissolved, then use, using an inhaler, either injected through the endotracheal probe or bronchodematoscopy. The number of procedures depends on how effective the treatment is, and also on the course of the pathology. It is necessary to wash the nose or rinse the oral cavity with warm water after the inhalation. The patient should immediately after the procedure cough up the accumulated sputum (or it should be sucked if puncturing fails).

In surgical procedures, the solution is administered:

• intramuscularly (with otitis, thrombophlebitis, purulent sinusitis, osteomyelitis, etc.);
• intrapleural (with empyema or hemothorax);
• under the scab, using a syringe that has a thin needle (with pressure sores or burns);
• Locally - using tampons previously moistened in solution (elimination of purulent wounds).

Dose sizes and frequency of procedures depend on the medicinal indications.

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Use of the chymotrypsin during pregnancy

There is no information on the use of chymotrypsin in nursing mothers and pregnant women.

Contraindications

Among the contraindications:

• Decompensated heart activity;
• pulmonary emphysema on the background of insufficiency of respiratory function;
• hepatic cirrhosis, and in addition, dystrophy;
• infectious form of hepatitis, pancreatitis, as well as hemorrhagic diathesis.

It is forbidden to inject the solution into cavities, in which there were bleeding, and in addition to apply it to ulcers formed on the surface of the existing malignant formations.

Caution is necessary in the case of using respiratory ducts in people with tuberculosis in active form (the medicine must necessarily be combined with specific drugs).

[11], [12], [13],

Side effects of the chymotrypsin

After applying the solution, side effects may occur in the form of hyperemia and pain at the site of administration, and in addition manifestations of allergies, tachycardia and transient increase in temperature.

Occasionally there are edemas or irritation in the conjunctiva; After performing the inhalation, hoarseness may develop.

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Interactions with other drugs

Chymotrypsin can be combined with bronchodilators, as well as antibiotics.

If you use a medicine to prevent or eliminate allergy, you can combine it with antihistamines.

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Storage conditions

Chymotrypsin should be stored in a place that is closed from sunlight. Temperature limits are 0-10 ° C.

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Shelf life

Chymotrypsin can be used no more than 3 years after the manufacture of the medicine.

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