Chlorprotixen

Chlorprotixen is a neuroleptic of the sedative type, and has a large range of medicinal uses.

[1], [2], [3], [4],

Indications of the chloroprotxene

It is used for such disorders:

• associated with a hangover abstinence, which is observed against the background of alcoholism / drug addiction;
• psychoses (also schizophrenia and emotional states of manic type), against which agitation, anxiety, and at the same time excitement of psychomotor character are noted;
• behavioral disorders observed in children;
• state of insomnia;
• feeling of irritability, strong excitement, hyperactivity, and besides confusion of consciousness, noted in the elderly;
• painful sensations (the medicine is combined with anesthetics).

[5], [6], [7]

Release form

The release occurs in tablets with a volume of 15 or 50 mg. Inside the blister pack - 10 tablets. The box contains 3 such blisters.

In addition, drugs are released in medicinal drops and as an injectable solution inside the ampoules in a volume of 2 ml (or 50 mg). The box contains 10 or 100 ampoules.

[8], [9], [10], [11]

Pharmacodynamics

The drug is part of a group of neuroleptic drugs (antipsychotics). The effect of drugs is provided by blocking the dopamine receptors. Thanks to the blocking of these conductors, an anti-emetic and anesthetic effect also develops.

Along with this, the drug has antihypertensive and antihistamine properties, blocking the receptors 5-HT2, α1-adrenoreceptors, and in addition conductors of histamine (H1).

[12], [13], [14],

Pharmacokinetics

After drinking drugs inside, the level of its bioavailability is about 12%. There is a rapid absorption of the drug from the digestive tract. After a lapse of 2 hours, the peak values of the drug active substance are observed inside the blood serum.

The half-life of the drug is approximately 16 hours. Chlorprotixen penetrates the placenta and is excreted in small amounts with the mother's milk. Metabolism products have no neuroleptic effect.

Excretion is carried out with feces and urine.

[15], [16], [17], [18]

Dosing and administration

Treatment of hangover abstinence, provoked by alcohol or drugs.

For a day in tablets it is required to take 0,5 g LS - this portion is divided into 2-3 uses. Therapy usually lasts for 7 days. After the disappearance of symptoms of withdrawal, the dosage size is gradually reduced. The size of the maintenance dose is 15-45 mg / day. This is enough to reduce the risk of developing a new binge, as well as stabilizing the condition.

To eliminate psychoses, including schizophrenia and a manic condition.

To begin therapy it is necessary from reception of a daily portion equal 50-100 mg. Further, the dose is gradually increased until optimal performance is achieved (usually within 0.3 g). Occasionally, an increase in dosage of up to 1.2 g / day is required. The maintenance dose per day is approximately 0.1-0.2 g.

Often, the daily portion is divided into 2-3 uses. It is recommended to take a smaller portion of the volume in the afternoon, and in the evening - a large portion. This is due to the fact that the drug has a pronounced sedative effect.

Therapy for depression, neurosis, and in addition to psychosomatic disorders.

For monotherapy or in combination with antidepressants, the medication is used in depression states, especially if there is a sense of anxiety on their background.

In psychosomatic disorders, against which there is a feeling of anxiety and depression, and at the same time with neuroses take a portion of the drug, which is not more than 90 mg / day. Often the daily dose is divided into several separate uses.

Since the drug does not cause addiction and drug dependence, it can be taken with long courses without the risk of complications.

Use of drugs to eliminate insomnia.

Take 15-30 mg of Chlorprothixen 1 hour before bedtime.

Treatment of pain.

The medicine can enhance the analgesic effect, which allows you to assign it to eliminate pain. In this case, the drug is used in combination with analgesics, and the size of the portion is in the range of 15-300 mg.

[27], [28], [29], [30]

Use of the chloroprotxene during pregnancy

It is forbidden to prescribe the drug Chlorprotixen to pregnant or breast-feeding women.

Contraindications

Among the contraindications:

• various suppressive effects in relation to the central nervous system (among them, suppression, provoked by the use of barbiturates or opiates, as well as the use of alcohol);
• pheochromocytoma;
• vascular collapse;
• state of coma;
• diseases affecting the hematopoiesis system;
• strong intolerance with regard to the elements contained in the drug.

[19]

Side effects of the chloroprotxene

The use of the drug may lead to the development of the following side effects:

• disorders of the function of the NS: development of inhibition of psychomotor character, extrapyramidal syndrome of mild manifestation, a feeling of severe fatigue, and in addition to this dizziness is possible. Sometimes there is a significant increase in anxiety, which most often develops in persons with mania or schizophrenics;
• manifestations on the part of the CAS: there may be changes in ECG indications, development of orthostatic collapse or tachycardia;
• problems from the hepatobiliary system: there is a risk of developing cholestatic jaundice;
• disorders of hematopoietic activity: the appearance of leukopenia or leukocytosis, and in addition agranulocytosis or hemolytic anemia;
• Symptoms on the part of the visual organs: opacity of the cornea with the lens, which leads to a weakening of vision;
• disorders of metabolic processes: it is possible to disrupt the metabolism of carbohydrates, increase weight and increase appetite, and in addition the development of hyperhidrosis;
• manifestations of endocrine organs: the development of galactorrhea, amenorrhea or gynecomastia, and in addition, a decrease in potency and libido;
• disorders affecting the dermal surface: the development of photosensitivity or photodermatitis;
• symptoms associated with the anticholinergic effect of drugs: the development of dysuria or constipation, accommodation disorders and dryness of oral mucosa.

[20], [21], [22], [23], [24], [25], [26]

Overdose

When poisoning possible development of such signs: hypothermia or hyperthermia, extrapyramidal disorders, convulsions, a feeling of drowsiness, and also coma or shock.

If an overdose is observed, symptomatic and supportive treatment procedures are required. As soon as possible, perform gastric lavage and give the sorbents to the victim. It is also necessary to carry out procedures that support the function of the respiratory system and CAS. It is forbidden to use epinephrine, because it can cause a decrease in blood pressure. Extrapyramidal manifestations are eliminated with biperiden, and convulsions with diazepam.

[31], [32], [33], [34]

Interactions with other drugs

The combined use of drugs with ethyl alcohol or drugs, in which it is, and also with hypnotics, anesthetics, neuroleptics, sedatives and opiates, can potentiate the inhibitory effect of Chlorprotixen on the CNS.

The drug potentiates the effectiveness of antihypertensive drugs.

Combined use with adrenaline can cause a decrease in the values of blood pressure, and in addition the development of tachycardia.

Chlorprotixen reduces the convulsive threshold, so people suffering from epilepsy need to change the sizes of the portions of the anticonvulsants taken.

Sharing with metoclopramide, haloperidol, phenothiazines or reserpine may cause the development of extrapyramidal disorders.

The ability of Chloroprotoxen to block the conductors of dopamine also contributes to a decrease in the effectiveness of levodopa.

[35], [36]

Storage conditions

Chlorprotixen should be kept in a dry place, where sunlight does not penetrate. The temperature is not above 25 ° C.

[37]

Shelf life

Chlorprotixen is allowed to be used for 2 years after the release of the therapeutic agent.

[38]

Reviews

Chlorprotixen is considered to be a fairly effective hypnotic, but the opinions of patients differ with respect to its effects in the treatment of psychoses. Some of them believe that the medicine is capable of eliminating psychoses with high efficiency, but most patients still note that for such purposes it is not too suitable. Most of the reviews suggest that the drug has an excellent hypnotic effect and a little help in the treatment of psychosis.

Among the shortcomings of the drug note that after taking it causes a feeling of drowsiness, and at the same time, some inhibition. Some of the patients complained of the development of severe anxiety due to hallucinations. But in general, most reviews about this drug on the forums are positive.

Doctors also note that Chlorprotixen is a good antipsychotic, but it has quite strict indications for use. The medicine is forbidden to combine with alcoholic beverages. In addition, it also requires strict adherence to the dosage prescribed by the doctor.