Chlorotrianizin

Chlorotrianizen - an antitumor drug, an artificial analog of female sex hormones - estrogens.

[1], [2], [3], [4], [5], [6], [7]

Indications of the chlorotriazinene

It is used for prostate cancer, as well as for breast cancer (only for women who are late in the menopause, who have been removed from the uterus).

[8], [9], [10], [11]

Release form

The release is made in tablets with a volume of 12 mg, in the amount of 50 or 100 pieces inside the container. Also, the tablets can be packed in blisters, 10 pieces inside one. In the box - 5 or 10 such blister packs.

Pharmacodynamics

The drug depresses the process of reproduction of tumor cells at any stage of prostate cancer, and in addition reduces the volume of produced sex hormones. If you compare it with other artificial estrogenic drugs, this remedy has a longer lasting effect.

If the tumors have an estrogen-resistant form, Chlorotrianizen will be ineffective.

Has a weak feminizing effect (after its admission in men there is a formation of secondary sexual characteristics - there is a deposition of fat stores in the hip area, as well as an increase in the mammary glands).

Increases blood loss, reduces cholesterol, and also triglyceride levels inside the blood. It helps to move the liquid located inside the vessels into the extracellular environment, resulting in the formation of puffiness. Has fewer central effects compared to drugs that contain estradiol and estrone.

[12], [13], [14]

Dosing and administration

The drug is used orally, along with food.

In the treatment of prostate cancer, it is required to take 1 tablet of medicine (12 mg) at a frequency of 2-3 times / day. If the patient has metastases, it is necessary to additionally use prednisolone.

With breast cancer, 1-nd tablet of the drug is taken four times a day - this is the size of the optimal daily dose (48 mg).

The sizes of the maximum permissible adult portions are 12 mg (single dose) and 48 mg (daytime).

The medicine is used for a long time. Individual doctor determines the individual course for each person.

Use of the chlorotriazinene during pregnancy

It is forbidden to use Chlortrianizinum during feeding or pregnancy.

If the drug should be taken with lactation, it should be discarded for the period of treatment from breastfeeding.

Contraindications

The main contraindications:

• the presence of intolerance relative to the elements of the drug;
• liver disease in acute or chronic degree;
• bleeding in the genital area, with an unexplained etiology;
• presence of an anamnesis of thromboembolic disorders.

[15], [16], [17]

Side effects of the chlorotriazinene

Taking the drug may cause the following side effects:

• disorders affecting the digestive function: loss of appetite, nausea, and in addition diarrhea or vomiting;
• manifestations on the part of the reproductive organs: pain or swelling in the thoracic glands, bleeding from the uterus (women) and feminization (men);
• disorders in the systemic blood flow and SSS: symptoms of circulatory failure, swelling, complications of thromboembolic character, increased bleeding, increased blood pressure, and blood turnover and blood viscosity;
• Other: a disorder of mineral metabolism and signs of allergy.

Overdose

Signs of poisoning: the occurrence of vomiting with nausea.

To remove an overdose, symptomatic procedures will be required. The medicine does not have a special antidote.

[18], [19], [20], [21], [22]

Interactions with other drugs

Signs of poisoning: the occurrence of vomiting with nausea.

To remove an overdose, symptomatic procedures will be required. The medicine does not have a special antidote.

[23], [24]

Storage conditions

Chlorotriazine is required to be kept in a place that is closed from children's access. Temperatures are not higher than 25 ° C.

[25]

Shelf life

Chlorotrianizen is allowed to be used for 5 years from the date of release of the drug.