The medicine can be prescribed only by a doctor who has sufficient experience in this field.
Caution is required to appoint if the patient has symptoms and manifestations of active allergic reactions, or if there is a history of allergies. In severe forms of allergies, Cetrotide should not be prescribed.
The first injection should be carried out under the supervision of the doctor and in such conditions, under which it will be possible to immediately provide assistance in case of pseudoallergic / allergic manifestations. Subsequent injections a woman can perform on her own until she feels symptoms that can indicate the appearance of signs of hypersensitivity or the development of the consequences of these manifestations - in such cases urgent medical care will be needed.
Injection of the solution is performed by the n / k method in the area of the lower part of the peritoneum (it is recommended to choose a site around the navel). To reduce the risk of local reactions, each injection needs to be done in different parts of the body without introducing the solution into the same place. In addition, it is recommended to inject slowly to ensure gradual absorption.
After the first injection, follow the patient for half an hour to ensure that there are no complications due to the use of Cetrotide.
The drug is administered once (use Cetrotide 3 mg) or in the form of a course of everyday procedures (0.25 mg drug) during the middle and early follicular stage. If the attending physician has not proposed a different scheme for administering the solution, it is required to use it in accordance with the recommendations described below.
Cetrotide in the form of release 0.25 mg.
It is necessary to administer the solution once a day (in the morning or in the evening), observing 24-hour intervals between the procedures.
In the morning injection: the medication should be started on the 5th or 6th day of the ovarian induction cycle (approximately 96-120 hours after the ovarian induction begins with the use of the drugs of recombinant or chorionic gonadotropin), and then continue the entire period of gonadotropin administration (this includes also the day of stimulation of ovulation or the day of injection of HC).
In case of evening injection: the solution should be started on the 5th day of the cycle (approximately 96-108 hours after the ovarian induction course begins with the use of recombinant or urinary gonadotropin), and then continue with the entire period of gonadotropin use until evening (inclusive ) before the day when the stimulation of ovulation is performed.
Cetrotide in the form of 3 mg.
It is required to administer the solution after the indicative indicator of estradiol is reached inside the serum (the element responsible for the desired response to the induction being performed). Often this day is the 7th day of ovarian induction (approximately 132-144 hours after ovarian induction begins, during which drugs containing recombinant or chorionic gonadotropin are used).
If the follicular function does not make it possible to perform ovulation stimulation on the 5th day after the injection of 3 mg of the drug, then 96 hours after this procedure (day 5) it is required to additionally administer the drug in the amount of 0.25 mg once a day before the moment ovarian induction inclusive.