^

Health

Ceruloplasmin

, medical expert
Last reviewed: 03.07.2025
Fact-checked
х

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

Ceruloplasmin is a stimulator of the erythropoiesis process, a detoxifying drug. It is a glycoprotein of the α-globulin serum fraction of human blood.

trusted-source[ 1 ], [ 2 ], [ 3 ], [ 4 ], [ 5 ], [ 6 ]

Indications Ceruloplasmin

It is used in the following situations:

  • to stimulate the hematopoietic process – hematopoiesis;
  • to reduce the degree of poisoning, and also to correct immune function (restoration and enhancement of immunity) during combined treatment of oncological pathologies;
  • during preparation before surgery in weakened patients suffering from anemia, poisoning, or exhaustion;
  • at an early stage in the postoperative period (with excessive blood loss during the procedure);
  • to eliminate complications of a purulent-septic nature (arising as a result of infection; in this case, blood is infected with microbes, as a result of which abscesses form in the tissues), during the early stage of the postoperative period;
  • during complex chemotherapy in the fight against oncological diseases (also in people with hemoblastoses - these are tumors that form from cells within the hematopoietic system) in the case of mild poisoning.

Ceruloplasmin can be used as an additional agent during the treatment of chronic and acute osteomyelitis (an inflammatory process in the bone marrow and adjacent bone tissue).

trusted-source[ 7 ], [ 8 ], [ 9 ]

Release form

It is produced in the form of a lyophilisate for the preparation of solutions administered intravenously, in ampoules or vials with a volume of 0.1 g. The pack contains 5 such vials or 10 ampoules.

trusted-source[ 10 ], [ 11 ], [ 12 ], [ 13 ], [ 14 ]

Pharmacodynamics

Ceruloplasmin is a plasma protein that has a large number of important biological functions for the body:

  • enhances the stability of cell membranes;
  • is a participant in immunological processes and reactions (in the formation of the body's protective functions), as well as ion metabolism;
  • has antioxidant properties (prevents peroxidative processes in lipid cell membranes);
  • slows down the process of lipid peroxidation;
  • activates hematopoietic processes – hematopoiesis.

The content of the substance ceruloplasmin in the serum is significantly reduced in the presence of hepatolenticular degeneration (a hereditary pathology that develops in the brain and liver due to a disorder of copper and protein metabolism). This indicator is very important in diagnostics.

trusted-source[ 15 ], [ 16 ], [ 17 ], [ 18 ], [ 19 ], [ 20 ], [ 21 ]

Dosing and administration

The injection is carried out intravenously (30 drops per minute). Before the procedure, it is necessary to dissolve the contents of the ampoule or bottle in a solution (volume 200 ml) of sodium chloride or glucose (5%).

In oncological pathologies, during the patient's preparation for surgery, it is necessary to administer a solution in the amount of 1.5-2.0 mg/kg. The therapeutic course in this case is 7-10 injections (every day or every other day - depending on the patient's health condition).

During the postoperative period, a single dose is prescribed in accordance with the amount of blood loss - starting from 1.5 mg/kg (if the patient has lost a little blood) and up to 6 mg/kg (in case of severe blood loss). The course is 7-10 days with the procedure performed daily (once per day).

During chemotherapy, a single dose is 4-6 mg/kg, and the treatment course includes 10-14 procedures (3 injections over 7 days). For patients with hemoblastoses, the single dose is 1.5-3 mg/kg, and the number of injections is 7-10 procedures, which are performed once a day every day.

To eliminate the acute form of osteomyelitis, the single dose is 2.5 mg/kg, during the course it is necessary to carry out 5 procedures (every day or every other day). To treat the chronic form of the pathology, the solution must be administered in the amount of 5 mg/kg twice/three times a day, making intervals of 1-2 days, after which 3-7 procedures with a dose of 2.5 mg/kg (every other day) are performed.

When treating children, the following doses of Ceruloplasmin are prescribed:

  • for children aged 6 months/1 year – 50 mg (or 100 ml of injection solution);
  • children aged 1-12 years – 100 mg;
  • for adolescents aged 13-18 years – 200 mg.

When treating or preventing posthemorrhagic anemia (during surgery), children should be given the drug 2 days before surgery, intraoperatively, and also for 2-10 days after the surgical procedure.

During therapy or prevention of anemia in children with purulent-surgical pathologies, the solution should be administered every day for 7-10 days during antibacterial treatment.

For children with oncological pathologies, for the treatment or prevention of the development of radiation anemia due to radiation therapy, Ceruloplasmin must be administered once a week during the entire course of radiotherapy.

When treating or preventing the development of toxic anemia, the solution is administered throughout the entire chemotherapy course on the days the procedures are performed.

Treatment or prevention of anemia resulting from chemoradiation procedures (radiation or toxic form) the drug is administered once a week on the day of the procedure for the entire duration of therapy.

trusted-source[ 29 ], [ 30 ], [ 31 ], [ 32 ], [ 33 ], [ 34 ], [ 35 ]

Use Ceruloplasmin during pregnancy

The drug is prescribed for combined treatment of anemia in the 2nd and 3rd trimesters. Together with the iron medications used (the level of ferritin and iron in the serum is taken into account), Ceruloplasmin is additionally used in the amount of 100 mg (the solution is administered intravenously by drip every day for 5 days).

It is prohibited to use the solution in the 1st trimester, as well as during lactation (since there is no information on the safety and effectiveness of the drug in this group of patients).

Contraindications

Contraindicated for use in case of intolerance to drugs of protein nature. In addition, do not use in infants under 6 months (since there is no information on the use of the drug in this group of patients).

trusted-source[ 22 ], [ 23 ], [ 24 ], [ 25 ]

Side effects Ceruloplasmin

At the early stage of using the solution, side effects such as nausea, flushing of the skin on the face, skin rash (urticaria), as well as chills and a transient increase in temperature may develop. In case of such disorders, it is necessary to reduce the dosage and the rate of administration of the solution or cancel the drug.

trusted-source[ 26 ], [ 27 ], [ 28 ]

Storage conditions

The solution is stored in a place inaccessible to small children. Temperature indicators are within 2-8°C.

trusted-source[ 36 ], [ 37 ], [ 38 ]

Shelf life

Ceruloplasmin can be used for a period of 2 years from the date of release of the medicinal solution.

trusted-source[ 39 ], [ 40 ], [ 41 ]

Attention!

To simplify the perception of information, this instruction for use of the drug "Ceruloplasmin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

You are reporting a typo in the following text:
Simply click the "Send typo report" button to complete the report. You can also include a comment.