Cephenap-M

Cephenap-M is an NSAID and has anti-rheumatic properties.

Indications Cephenapa-M

It is used to treat the following disorders:

• a febrile condition that occurs with the development of a disease having an infectious and inflammatory origin, as well as with inflammatory pathologies in the large intestine (such as sphincteritis with proctosigmoiditis, cracks in the rectum and hemorrhoids );
• as an antipyretic, analgesic and anti-inflammatory drugs in situations where oral medications with a similar therapeutic effect after their administration cause irritation in the gastrointestinal tract, because of what their use is impossible.

In addition, the drug can be used for headaches or dental pain, pain caused by trauma or surgery, as well as with neuralgia.

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Release form

The release is carried out in the form of rectal suppositories.

Pharmacodynamics

A complex drug containing 2 substances of NSAIDs is salicylamide with naproxen. They have analgesic, anti-inflammatory and anti-pyretic effect. Also, the caffeine contained in the preparation potentiates the above properties.

Pharmacokinetics

The half-life of naproxen is 12-15 hours, so that the medicine can be consumed twice a day. Naproxenum more actively cumulates inside synovial tissues, in comparison with other derivatives of propionic acid. As a result, a high drug concentration is created at the site of inflammation. The therapeutic activity of the substance develops rapidly, keeping high indices up to 12 hours.

Dosing and administration

It is required to administer suppositories rectally, deeply. The procedure is carried out after an arbitrary intestinal bowel movement or a cleansing enema. You need to enter 1 suppository, 1-3 times a day. After the end of the procedure, the patient should remain in a horizontal position for another 30-40 minutes.

The duration of the therapy is a maximum of 6 days.

Use Cephenapa-M during pregnancy

Appoint Cephenap-M lactating or pregnant women need very carefully. It is recommended to give up breastfeeding for the duration of therapy.

Contraindications

The main contraindications:

• the presence of hypersensitivity against medicinal substances;
• elevated values of blood pressure in a pronounced form;
• diseases affecting the work of the CAS, and having an organic nature;
• insomnia or strong excitability;
• glaucoma;
• presence in the anamnesis of spasms of bronchuses, which were caused by the use of NSAIDs;
• problems with the liver or kidneys, which have a pronounced character;
• aged people.

Side effects Cephenapa-M

The use of suppositories can trigger the appearance of the following side-effects:

• signs of allergy;
• thrombocytopenia or granulocytopenia, as well as the aplastic form of anemia;
• feeling of weakness or drowsiness, dizziness, ear noise and decreased speed of psychomotor reflexes;
• auditory disorders;
• disorders of renal or hepatic functional activity;
• pain and itching, developing in the rectal area.

Sometimes you can expect the development of tachycardia or arousal, as well as an increase in blood pressure.

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Overdose

Intoxication with medication can lead to the appearance of tachycardia, dizziness, spasms of the bronchi, as well as pain or itching in the rectal area. In addition, heart failure or a disorder of renal or hepatic function may develop, and the level of blood pressure may also increase.

When these signs appear, it is necessary to cancel the medicine and carry out symptomatic measures, including lowering the values of blood pressure and maintaining the heart.

If there is an itching or a feeling of discomfort in the rectal area, you should inject sunflower oil through the enema.

Interactions with other drugs

It is forbidden to combine hypotensive, diuretic and hypoglycemic medications, as well as anticoagulants and lithium medications with Cefenap-M.

The drug weakens the antihypertensive effect of ACE inhibitors and β-blockers, as well as increases the effects of sulfonylurea derivatives and anticoagulants.

Potentiates the therapeutic properties of antihypertensive drugs and anticonvulsants.

Combination with hypertension may lead to an increase in their plasma values, exacerbation of heart failure, and weakening of glomerular filtration.

Combined use with diuretic drugs increases the likelihood of developing nephrotoxic effects of NSAIDs that are part of the drug.

Combination with lithium agents reduces the volume of excreted lithium, which can increase the loss of fluid and weaken the tolerability of these drugs.

Probenecid (a uricosuric agent) interferes with excision of naproxen and increases its indices inside the blood plasma.

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Storage conditions

Cephenap-M is required to be kept in a dark and dry place, inaccessible to infiltration of small children. The temperature level is within the limits of 8-15 ° C.

Shelf life

Cephenap-M is allowed to be used within 24 months after the release of the drug.

Application for children

The medication is prescribed to adolescents who have reached the age of 16.

Analogues

Analogues of the medication are Moveks and Afenak, as well as Rebon with Zelid plus.